Pathway: VTN

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: ECM-Receptor

Details on the VTN pathway:

Specificity Index HSPC as target: 0.117
HSPC as source: 0.253

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the VTN pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target VTN Source CD34 CD34 Cell-Cell Contact 0.1036 0.020445425066499 Scatter Plot
Target VTN Source IL6 IL6 Secreted Signaling 0.1110 0.0130175833714914 Scatter Plot
Target VTN Source SEMA6 SEMA6 Cell-Cell Contact 0.1123 0.0119501129796451 Scatter Plot
Target VTN Source WNT WNT Secreted Signaling 0.1126 0.0117356011646087 Scatter Plot
Target VTN Target RANKL RANKL Secreted Signaling 0.1208 0.006848201140394 Scatter Plot
Target VTN Target CXCL CXCL Secreted Signaling 0.1306 0.0034449430299182 Scatter Plot
Target VTN Source APELIN APELIN Secreted Signaling 0.1325 0.0030012607917121 Scatter Plot
Target VTN Source IL16 IL16 Secreted Signaling 0.1520 0.000651456430444 Scatter Plot
Target VTN Source THBS THBS ECM-Receptor 0.1567 0.0004348611175315 Scatter Plot
Target VTN Target AGT AGT Secreted Signaling 0.1574 0.000412191725619 Scatter Plot
Target VTN Source GDF GDF Secreted Signaling 0.1583 0.0003817544030247 Scatter Plot
Target VTN Source GALECTIN GALECTIN Secreted Signaling 0.1618 0.0002795221292083 Scatter Plot
Target VTN Target EPHA EPHA Cell-Cell Contact 0.1618 0.0002792012301072 Scatter Plot
Target VTN Target GAS GAS Secreted Signaling 0.1635 0.0002402650175316 Scatter Plot
Target VTN Target SEMA3 SEMA3 Secreted Signaling 0.1733 0.00009779406489487216 Scatter Plot
Target VTN Source CD1D2 CD1D2 Cell-Cell Contact 0.1744 0.0000885246895529308 Scatter Plot
Target VTN Source CD39 CD39 Cell-Cell Contact 0.1797 0.00005328704667205037 Scatter Plot
Target VTN Target GDF GDF Secreted Signaling 0.1816 0.000044039961591962655 Scatter Plot
Target VTN Source SEMA3 SEMA3 Secreted Signaling 0.1826 0.0000400924966163061 Scatter Plot
Target VTN Source ANGPTL ANGPTL Secreted Signaling 0.1876 0.000024307957665901424 Scatter Plot
Target VTN Source VEGF VEGF Secreted Signaling 0.2044 0.000004053460313687894 Scatter Plot
Target VTN Source CCL CCL Secreted Signaling 0.2104 0.000002077085317866926 Scatter Plot
Target VTN Source ncWNT ncWNT Secreted Signaling 0.2116 0.0000018052022076917387 Scatter Plot
Target VTN Source IL1 IL1 Secreted Signaling 0.2140 0.0000013713292761253202 Scatter Plot
Target VTN Source NOTCH NOTCH Cell-Cell Contact 0.2350 0.00000010638424272068345 Scatter Plot
Target VTN Source RANKL RANKL Secreted Signaling 0.2361 0.00000009248300354314716 Scatter Plot
Target VTN Source IL2 IL2 Secreted Signaling 0.2382 0.00000006995132534621228 Scatter Plot
Target VTN Source CD46 CD46 Cell-Cell Contact 0.2422 0.000000041510096126510654 Scatter Plot
Target VTN Source GP1BA GP1BA Cell-Cell Contact 0.2504 0.000000013838114009378588 Scatter Plot
Target VTN Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.2537 0.00000000879706137114774 Scatter Plot
Target VTN Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2544 0.000000007927429785031944 Scatter Plot
Target VTN Target CADM CADM Cell-Cell Contact 0.2560 0.000000006338955021770191 Scatter Plot
Target VTN Source CADM CADM Cell-Cell Contact 0.2560 0.000000006338955021770191 Scatter Plot
Target VTN Source FGF FGF Secreted Signaling 0.2597 0.0000000037396381428090075 Scatter Plot
Target VTN Source NT NT Secreted Signaling 0.2712 0.0000000007023847514500643 Scatter Plot
Target VTN Target VEGF VEGF Secreted Signaling 0.2715 0.0000000006746903833231864 Scatter Plot
Target VTN Source CSF CSF Secreted Signaling 0.2743 0.00000000044063905069938157 Scatter Plot
Target VTN Source PTN PTN Secreted Signaling 0.2772 0.00000000028509061770639087 Scatter Plot
Target VTN Source THY1 THY1 Cell-Cell Contact 0.2804 0.00000000017401687971420082 Scatter Plot
Target VTN Source CD86 CD86 Cell-Cell Contact 0.2809 0.000000000161229522914139 Scatter Plot
Target VTN Source CD45 CD45 Cell-Cell Contact 0.2855 0.00000000007777181450369302 Scatter Plot
Target VTN Target CD200 CD200 Cell-Cell Contact 0.2887 0.000000000047188070933065287 Scatter Plot
Target VTN Target SEMA6 SEMA6 Cell-Cell Contact 0.2899 0.00000000003901401409613239 Scatter Plot
Target VTN Source IGF IGF Secreted Signaling 0.2978 0.000000000010710608459255886 Scatter Plot
Target VTN Target EPHB EPHB Cell-Cell Contact 0.2984 0.000000000009605106691145958 Scatter Plot
Target VTN Target SEMA5 SEMA5 Cell-Cell Contact 0.2984 0.000000000009579942486084602 Scatter Plot
Target VTN Source EPHB EPHB Cell-Cell Contact 0.3167 0.0000000000004078657935767112 Scatter Plot
Target VTN Target ACTIVIN ACTIVIN Secreted Signaling 0.3195 0.0000000000002500048177520041 Scatter Plot
Target VTN Source CX3C CX3C Secreted Signaling 0.3254 0.00000000000008432527935393781 Scatter Plot
Target VTN Source PSAP PSAP Secreted Signaling 0.3275 0.00000000000005814311678795573 Scatter Plot
Target VTN Target KIT KIT Secreted Signaling 0.3305 0.00000000000003308086063581244 Scatter Plot
Target VTN Source LIGHT LIGHT Secreted Signaling 0.3340 0.00000000000001705057232455436 Scatter Plot
Target VTN Target BMP BMP Secreted Signaling 0.3412 0.000000000000004230841714106543 Scatter Plot
Target VTN Source LAMININ LAMININ ECM-Receptor 0.3485 0.0000000000000009945316321110871 Scatter Plot
Target VTN Source CXCL CXCL Secreted Signaling 0.3526 0.0000000000000004349867689742476 Scatter Plot
Target VTN Source BST2 BST2 Cell-Cell Contact 0.3614 0.00000000000000007144420143508494 Scatter Plot
Target VTN Source ICAM ICAM Cell-Cell Contact 0.3634 0.00000000000000004642692273013295 Scatter Plot
Target VTN Source CDH CDH Cell-Cell Contact 0.3673 0.00000000000000002037515318448849 Scatter Plot
Target VTN Target CDH CDH Cell-Cell Contact 0.3673 0.00000000000000002037515318448849 Scatter Plot
Target VTN Source LCK LCK Cell-Cell Contact 0.3702 0.00000000000000001090813983999562 Scatter Plot
Target VTN Source MK MK Secreted Signaling 0.3746 0.00000000000000000418540865193708 Scatter Plot
Target VTN Target NPR2 NPR2 Secreted Signaling 0.3875 0.0000000000000000002324568567872681 Scatter Plot
Target VTN Source SEMA7 SEMA7 Cell-Cell Contact 0.3917 0.00000000000000000008659347020149441 Scatter Plot
Target VTN Target SLURP SLURP Secreted Signaling 0.3929 0.00000000000000000006577083070682574 Scatter Plot
Target VTN Source FLT3 FLT3 Secreted Signaling 0.4170 0.00000000000000000000018512101598771608 Scatter Plot
Target VTN Source IL7 IL7 Secreted Signaling 0.4188 0.00000000000000000000011740685931836022 Scatter Plot
Target VTN Source COLLAGEN COLLAGEN ECM-Receptor 0.4194 0.00000000000000000000010033630043472468 Scatter Plot
Target VTN Source PROS PROS Secreted Signaling 0.4212 0.00000000000000000000006332695504345074 Scatter Plot
Target VTN Target MIF MIF Secreted Signaling 0.4265 0.00000000000000000000001605449756348045 Scatter Plot
Target VTN Target ncWNT ncWNT Secreted Signaling 0.4285 0.000000000000000000000009442754275782517 Scatter Plot
Target VTN Source GAS GAS Secreted Signaling 0.4354 0.0000000000000000000000014854556491980803 Scatter Plot
Target VTN Source PDGF PDGF Secreted Signaling 0.4388 0.000000000000000000000000587585471280401 Scatter Plot
Target VTN Target FGF FGF Secreted Signaling 0.4391 0.000000000000000000000000542544945512918 Scatter Plot
Target VTN Source BMP BMP Secreted Signaling 0.4555 0.0000000000000000000000000055477358045752926 Scatter Plot
Target VTN Target WNT WNT Secreted Signaling 0.4585 0.0000000000000000000000000022876838261032994 Scatter Plot
Target VTN Source LIFR LIFR Secreted Signaling 0.5083 0.00000000000000000000000000000000032985926000175444 Scatter Plot
Target VTN Source TWEAK TWEAK Secreted Signaling 0.5083 0.0000000000000000000000000000000003266410988564904 Scatter Plot
Target VTN Source MHC-II MHC-II Cell-Cell Contact 0.5168 0.000000000000000000000000000000000016820507905212888 Scatter Plot
Target VTN Target CD39 CD39 Cell-Cell Contact 0.5266 0.00000000000000000000000000000000000050617598924214814 Scatter Plot
Target VTN Source MHC-I MHC-I Cell-Cell Contact 0.5309 0.00000000000000000000000000000000000010431231824900822 Scatter Plot
Target VTN Source ESAM ESAM Cell-Cell Contact 0.5383 0.000000000000000000000000000000000000006358800198564151 Scatter Plot
Target VTN Source ANGPT ANGPT Secreted Signaling 0.5457 0.0000000000000000000000000000000000000003681137222617546 Scatter Plot
Target VTN Target PARs PARs Secreted Signaling 0.5698 0.000000000000000000000000000000000000000000020995160982677158 Scatter Plot
Target VTN Source JAM JAM Cell-Cell Contact 0.5826 0.00000000000000000000000000000000000000000000008482126373135051 Scatter Plot
Target VTN Source CD52 CD52 Cell-Cell Contact -0.4079 0.0000000000000000000018118435436384352 Scatter Plot
Target VTN Source SELL SELL Cell-Cell Contact -0.4008 0.000000000000000000010151185095595167 Scatter Plot
Target VTN Source COMPLEMENT COMPLEMENT Secreted Signaling -0.3968 0.00000000000000000002603148305695095 Scatter Plot
Target VTN Source PARs PARs Secreted Signaling -0.3413 0.00000000000000420082401580878 Scatter Plot
Target VTN Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.3388 0.000000000000006780884373929207 Scatter Plot
Target VTN Source SEMA4 SEMA4 Cell-Cell Contact -0.3084 0.000000000001759791447118612 Scatter Plot
Target VTN Source VISTA VISTA Cell-Cell Contact -0.2919 0.000000000028010806985909217 Scatter Plot
Target VTN Source CCL CCL Secreted Signaling -0.2674 0.0000000012420049561807684 Scatter Plot
Target VTN Source ANNEXIN ANNEXIN Secreted Signaling -0.2555 0.000000006802164929344426 Scatter Plot
Target VTN Source CLEC CLEC Cell-Cell Contact -0.2350 0.00000010524481095223317 Scatter Plot
Target VTN Target VEGF VEGF Secreted Signaling -0.2175 0.000000904398778590294 Scatter Plot
Target VTN Source ANGPTL ANGPTL Secreted Signaling -0.2076 0.000002852756085642713 Scatter Plot
Target VTN Target CXCL CXCL Secreted Signaling -0.1927 0.000014361955593003053 Scatter Plot
Target VTN Target CSF CSF Secreted Signaling -0.1916 0.000015985116132999796 Scatter Plot
Target VTN Source NCAM NCAM Cell-Cell Contact -0.1896 0.000019741434535856106 Scatter Plot
Target VTN Target IL17 IL17 Secreted Signaling -0.1648 0.0002146173855472 Scatter Plot
Target VTN Source SPP1 SPP1 Secreted Signaling -0.1601 0.0003259560895356 Scatter Plot
Target VTN Source MIF MIF Secreted Signaling -0.1562 0.0004540435750688 Scatter Plot
Target VTN Source TNF TNF Secreted Signaling -0.1470 0.0009743395337147 Scatter Plot
Target VTN Source LAIR1 LAIR1 Cell-Cell Contact -0.1194 0.0075085982513068 Scatter Plot
Target VTN Source APP APP Cell-Cell Contact -0.1138 0.0108700442457604 Scatter Plot
Target VTN Target ANNEXIN ANNEXIN Secreted Signaling -0.1137 0.0109308384226048 Scatter Plot
Target VTN Source VISFATIN VISFATIN Secreted Signaling -0.1089 0.0148637043052765 Scatter Plot
Target VTN Target SELL SELL Cell-Cell Contact 0.1219 0.0063322803646485 Scatter Plot
Target VTN Target NODAL NODAL Secreted Signaling 0.1496 0.000791812386318 Scatter Plot
Target VTN Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.2219 0.0000005364306784929794 Scatter Plot
Target VTN Target IL6 IL6 Secreted Signaling 0.2289 0.0000002272751134819909 Scatter Plot
Target VTN Target OSM OSM Secreted Signaling 0.2307 0.0000001816376257052121 Scatter Plot
Target VTN Target CD22 CD22 Cell-Cell Contact 0.2855 0.00000000007777181450369302 Scatter Plot
Target VTN Target TGFb TGFb Secreted Signaling 0.3308 0.000000000000031356574766251025 Scatter Plot
Target VTN Target APP APP Cell-Cell Contact 0.3479 0.0000000000000011397765814706534 Scatter Plot
Target VTN Target BAFF BAFF Secreted Signaling 0.3832 0.0000000000000000006099685614734394 Scatter Plot
Target VTN Target SEMA4 SEMA4 Cell-Cell Contact 0.4191 0.0000000000000000000001074768747256712 Scatter Plot
Target VTN Target ESAM ESAM Cell-Cell Contact 0.5383 0.000000000000000000000000000000000000006358800198564151 Scatter Plot
Target VTN Target CD34 CD34 Cell-Cell Contact 0.5723 0.000000000000000000000000000000000000000000007465646768417378 Scatter Plot
Target VTN Target IFN-II IFN-II Secreted Signaling -0.4055 0.0000000000000000000032394917317454787 Scatter Plot
Target VTN Target CD52 CD52 Cell-Cell Contact -0.3406 0.000000000000004790446575883036 Scatter Plot
Target VTN Target ICAM ICAM Cell-Cell Contact -0.3314 0.000000000000027533109721104657 Scatter Plot
Target VTN Target VCAM VCAM Cell-Cell Contact -0.2876 0.000000000055554534778703827 Scatter Plot
Target VTN Target CEACAM CEACAM Cell-Cell Contact -0.2408 0.0000000500829717247027 Scatter Plot
Target VTN Target CCL CCL Secreted Signaling -0.2386 0.00000006618642817486864 Scatter Plot
Target VTN Target VEGF VEGF Secreted Signaling -0.2175 0.000000904398778590294 Scatter Plot
Target VTN Target CLEC CLEC Cell-Cell Contact -0.1803 0.00005030604092207365 Scatter Plot
Target VTN Target COMPLEMENT COMPLEMENT Secreted Signaling -0.1389 0.0018483768535948 Scatter Plot
Target VTN Target GRN GRN Secreted Signaling -0.1278 0.0041983565974391 Scatter Plot

Cells that are targets of VTN from HSCs*

    No cell populations

Cells that are source of VTN to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.