Pathway: MHC-II

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Cell-Cell Contact

Details on the MHC-II pathway:

Specificity Index HSPC as target: 0.282
HSPC as source: 0.682

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the MHC-II pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Source MHC-II Source SEMA6 SEMA6 Cell-Cell Contact 0.1233 0.0057703188461725 Scatter Plot
Source MHC-II Source OSM OSM Secreted Signaling 0.1415 0.0015141617611386 Scatter Plot
Source MHC-II Source FGF FGF Secreted Signaling 0.1623 0.0002669893632672 Scatter Plot
Source MHC-II Source IL6 IL6 Secreted Signaling 0.1625 0.0002629796754377 Scatter Plot
Source MHC-II Source APELIN APELIN Secreted Signaling 0.1915 0.000016154555413336008 Scatter Plot
Source MHC-II Source ncWNT ncWNT Secreted Signaling 0.2023 0.000005127983412667553 Scatter Plot
Source MHC-II Source WNT WNT Secreted Signaling 0.2417 0.000000044116237379758575 Scatter Plot
Source MHC-II Source CD34 CD34 Cell-Cell Contact 0.2701 0.0000000008331336523460288 Scatter Plot
Source MHC-II Source VEGF VEGF Secreted Signaling 0.2754 0.00000000037244212588655767 Scatter Plot
Source MHC-II Source SEMA3 SEMA3 Secreted Signaling 0.2768 0.00000000030165360768604717 Scatter Plot
Source MHC-II Source CADM CADM Cell-Cell Contact 0.2960 0.00000000001435378957520965 Scatter Plot
Source MHC-II Source NT NT Secreted Signaling 0.3007 0.000000000006522747422079858 Scatter Plot
Source MHC-II Source ANGPTL ANGPTL Secreted Signaling 0.3270 0.00000000000006268843574116614 Scatter Plot
Source MHC-II Source CD46 CD46 Cell-Cell Contact 0.3317 0.000000000000026184478082676514 Scatter Plot
Source MHC-II Source GDF GDF Secreted Signaling 0.3502 0.000000000000000718241120300008 Scatter Plot
Source MHC-II Source CD39 CD39 Cell-Cell Contact 0.3657 0.00000000000000002872658230747448 Scatter Plot
Source MHC-II Source NOTCH NOTCH Cell-Cell Contact 0.4019 0.000000000000000000007805396680153493 Scatter Plot
Source MHC-II Source RANKL RANKL Secreted Signaling 0.4138 0.00000000000000000000041659824133236784 Scatter Plot
Source MHC-II Source LIGHT LIGHT Secreted Signaling 0.4182 0.0000000000000000000001366662131207199 Scatter Plot
Source MHC-II Source CCL CCL Secreted Signaling 0.4513 0.000000000000000000000000018174950170948408 Scatter Plot
Source MHC-II Source CXCL CXCL Secreted Signaling 0.4517 0.00000000000000000000000001639258851021519 Scatter Plot
Source MHC-II Source IGF IGF Secreted Signaling 0.4658 0.0000000000000000000000000002676297172644781 Scatter Plot
Source MHC-II Source PROS PROS Secreted Signaling 0.4895 0.0000000000000000000000000000001723155671401816 Scatter Plot
Source MHC-II Source EPHB EPHB Cell-Cell Contact 0.4945 0.0000000000000000000000000000000330109742095095 Scatter Plot
Source MHC-II Source LAMININ LAMININ ECM-Receptor 0.5172 0.000000000000000000000000000000000014410937629450272 Scatter Plot
Source MHC-II Source LIFR LIFR Secreted Signaling 0.5206 0.000000000000000000000000000000000004297501795395786 Scatter Plot
Source MHC-II Source FLT3 FLT3 Secreted Signaling 0.5286 0.0000000000000000000000000000000000002372961119135036 Scatter Plot
Source MHC-II Source PDGF PDGF Secreted Signaling 0.5481 0.0000000000000000000000000000000000000001488796372343386 Scatter Plot
Source MHC-II Source CDH CDH Cell-Cell Contact 0.5506 0.0000000000000000000000000000000000000000551213721017887 Scatter Plot
Source MHC-II Source CD45 CD45 Cell-Cell Contact 0.5611 0.0000000000000000000000000000000000000000007938536296697809 Scatter Plot
Source MHC-II Source MK MK Secreted Signaling 0.5855 0.000000000000000000000000000000000000000000000023625919279012357 Scatter Plot
Source MHC-II Source PSAP PSAP Secreted Signaling 0.6367 0.0000000000000000000000000000000000000000000000000000000003282002902381421 Scatter Plot
Source MHC-II Source TWEAK TWEAK Secreted Signaling 0.6643 0.00000000000000000000000000000000000000000000000000000000000000005620302427073266 Scatter Plot
Source MHC-II Source BMP BMP Secreted Signaling 0.6681 0.000000000000000000000000000000000000000000000000000000000000000005651461224339224 Scatter Plot
Source MHC-II Source ESAM ESAM Cell-Cell Contact 0.6964 0.00000000000000000000000000000000000000000000000000000000000000000000000008094781086402636 Scatter Plot
Source MHC-II Source COLLAGEN COLLAGEN ECM-Receptor 0.7349 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004454127477200759 Scatter Plot
Source MHC-II Source JAM JAM Cell-Cell Contact 0.7413 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002399294168826305 Scatter Plot
Source MHC-II Source GAS GAS Secreted Signaling 0.7421 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000012971788659441152 Scatter Plot
Source MHC-II Source ANGPT ANGPT Secreted Signaling 0.8118 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633115328717955 Scatter Plot
Source MHC-II Source CD52 CD52 Cell-Cell Contact -0.4997 0.000000000000000000000000000000005972254813433875 Scatter Plot
Source MHC-II Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.4818 0.000000000000000000000000000001954559485135826 Scatter Plot
Source MHC-II Source SEMA4 SEMA4 Cell-Cell Contact -0.4711 0.00000000000000000000000000005492131627271064 Scatter Plot
Source MHC-II Source SELL SELL Cell-Cell Contact -0.3890 0.0000000000000000001643554559966427 Scatter Plot
Source MHC-II Source VISTA VISTA Cell-Cell Contact -0.3605 0.00000000000000008536301336175583 Scatter Plot
Source MHC-II Source TGFb TGFb Secreted Signaling -0.3251 0.00000000000009037150252870532 Scatter Plot
Source MHC-II Source NCAM NCAM Cell-Cell Contact -0.3246 0.00000000000009877785621770404 Scatter Plot
Source MHC-II Source MIF MIF Secreted Signaling -0.3079 0.000000000001917852331152013 Scatter Plot
Source MHC-II Source SPP1 SPP1 Secreted Signaling -0.2423 0.000000041181985213296935 Scatter Plot
Source MHC-II Source ANGPTL ANGPTL Secreted Signaling -0.2262 0.0000003194372398554719 Scatter Plot
Source MHC-II Source APP APP Cell-Cell Contact -0.1810 0.000046833189039113766 Scatter Plot
Source MHC-II Source TNF TNF Secreted Signaling -0.1691 0.0001452896942613 Scatter Plot
Source MHC-II Source BAFF BAFF Secreted Signaling -0.1504 0.0007406676028338 Scatter Plot
Source MHC-II Target BST2 BST2 Cell-Cell Contact 0.1018 0.0228653998393418 Scatter Plot
Source MHC-II Target LAIR1 LAIR1 Cell-Cell Contact 0.1018 0.0228653998393418 Scatter Plot
Source MHC-II Source THBS THBS ECM-Receptor 0.1090 0.0147341643845726 Scatter Plot
Source MHC-II Target GAS GAS Secreted Signaling 0.1131 0.011352654112265 Scatter Plot
Source MHC-II Target PDGF PDGF Secreted Signaling 0.1202 0.0071230483506212 Scatter Plot
Source MHC-II Target NCAM NCAM Cell-Cell Contact 0.1404 0.0016431754968977 Scatter Plot
Source MHC-II Source GP1BA GP1BA Cell-Cell Contact 0.1406 0.0016224369464017 Scatter Plot
Source MHC-II Target THY1 THY1 Cell-Cell Contact 0.1462 0.0010421227114289 Scatter Plot
Source MHC-II Target AGT AGT Secreted Signaling 0.1483 0.0008792293824564 Scatter Plot
Source MHC-II Target TWEAK TWEAK Secreted Signaling 0.1608 0.0003069547298256 Scatter Plot
Source MHC-II Target SEMA3 SEMA3 Secreted Signaling 0.1716 0.0001156235965337 Scatter Plot
Source MHC-II Source ICOS ICOS Cell-Cell Contact 0.1798 0.000052418946387101375 Scatter Plot
Source MHC-II Target CD23 CD23 Cell-Cell Contact 0.1804 0.00004980398832464214 Scatter Plot
Source MHC-II Source PTN PTN Secreted Signaling 0.2155 0.0000011567750819714422 Scatter Plot
Source MHC-II Target OSM OSM Secreted Signaling 0.2373 0.00000007876073634630993 Scatter Plot
Source MHC-II Target RANKL RANKL Secreted Signaling 0.2384 0.00000006842142109209586 Scatter Plot
Source MHC-II Target EPHA EPHA Cell-Cell Contact 0.2414 0.000000045977752251735323 Scatter Plot
Source MHC-II Target NOTCH NOTCH Cell-Cell Contact 0.2446 0.000000030077730072266693 Scatter Plot
Source MHC-II Target GALECTIN GALECTIN Secreted Signaling 0.2536 0.00000000888827730403241 Scatter Plot
Source MHC-II Target VEGF VEGF Secreted Signaling 0.2572 0.000000005332116748255736 Scatter Plot
Source MHC-II Target COLLAGEN COLLAGEN ECM-Receptor 0.2643 0.0000000019417219536007362 Scatter Plot
Source MHC-II Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.2736 0.0000000004920367137142253 Scatter Plot
Source MHC-II Target SELL SELL Cell-Cell Contact 0.2753 0.00000000037886790295430617 Scatter Plot
Source MHC-II Target CADM CADM Cell-Cell Contact 0.2960 0.00000000001435378957520965 Scatter Plot
Source MHC-II Source CD1D2 CD1D2 Cell-Cell Contact 0.3001 0.000000000007251610083784079 Scatter Plot
Source MHC-II Target PTN PTN Secreted Signaling 0.3112 0.000000000001081839228663543 Scatter Plot
Source MHC-II Target CSPG4 CSPG4 Cell-Cell Contact 0.3289 0.000000000000044540321687898654 Scatter Plot
Source MHC-II Target GDF GDF Secreted Signaling 0.3327 0.00000000000002164476338189107 Scatter Plot
Source MHC-II Target NODAL NODAL Secreted Signaling 0.3419 0.000000000000003676583156513368 Scatter Plot
Source MHC-II Target MK MK Secreted Signaling 0.3432 0.000000000000002879644713047785 Scatter Plot
Source MHC-II Target IL6 IL6 Secreted Signaling 0.3477 0.0000000000000011867898580916144 Scatter Plot
Source MHC-II Target ANGPTL ANGPTL Secreted Signaling 0.3600 0.00000000000000009539716225245 Scatter Plot
Source MHC-II Target SPP1 SPP1 Secreted Signaling 0.3622 0.00000000000000006015933550385214 Scatter Plot
Source MHC-II Target SEMA6 SEMA6 Cell-Cell Contact 0.3656 0.000000000000000029290173362765016 Scatter Plot
Source MHC-II Target COMPLEMENT COMPLEMENT Secreted Signaling 0.3834 0.0000000000000000005806695648439009 Scatter Plot
Source MHC-II Target SEMA5 SEMA5 Cell-Cell Contact 0.3893 0.00000000000000000015244398789062202 Scatter Plot
Source MHC-II Target FN1 FN1 ECM-Receptor 0.3973 0.0000000000000000000232561564729211 Scatter Plot
Source MHC-II Source THY1 THY1 Cell-Cell Contact 0.4052 0.000000000000000000003499130389628095 Scatter Plot
Source MHC-II Target VISFATIN VISFATIN Secreted Signaling 0.4139 0.00000000000000000000040532199749878003 Scatter Plot
Source MHC-II Target SEMA7 SEMA7 Cell-Cell Contact 0.4145 0.0000000000000000000003518355801007928 Scatter Plot
Source MHC-II Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.4274 0.000000000000000000000012676059453059437 Scatter Plot
Source MHC-II Source VCAM VCAM Cell-Cell Contact 0.4572 0.000000000000000000000000003383597098858367 Scatter Plot
Source MHC-II Target THBS THBS ECM-Receptor 0.4608 0.0000000000000000000000000011741997621356894 Scatter Plot
Source MHC-II Source CSF CSF Secreted Signaling 0.4666 0.00000000000000000000000000021289724390541637 Scatter Plot
Source MHC-II Source IL2 IL2 Secreted Signaling 0.4721 0.00000000000000000000000000003978974920420589 Scatter Plot
Source MHC-II Source CX3C CX3C Secreted Signaling 0.4797 0.000000000000000000000000000003811515561831599 Scatter Plot
Source MHC-II Source IL16 IL16 Secreted Signaling 0.4803 0.000000000000000000000000000003201973135006516 Scatter Plot
Source MHC-II Target ACTIVIN ACTIVIN Secreted Signaling 0.4961 0.00000000000000000000000000000001990350971331073 Scatter Plot
Source MHC-II Target LAMININ LAMININ ECM-Receptor 0.4976 0.000000000000000000000000000000012113759402446359 Scatter Plot
Source MHC-II Target BMP BMP Secreted Signaling 0.5062 0.0000000000000000000000000000000006760082296862903 Scatter Plot
Source MHC-II Target EPHB EPHB Cell-Cell Contact 0.5112 0.00000000000000000000000000000000011790817773627731 Scatter Plot
Source MHC-II Target VTN VTN ECM-Receptor 0.5168 0.000000000000000000000000000000000016820507905212888 Scatter Plot
Source MHC-II Target VWF VWF ECM-Receptor 0.5178 0.000000000000000000000000000000000011999543469123184 Scatter Plot
Source MHC-II Target PERIOSTIN PERIOSTIN Secreted Signaling 0.5190 0.000000000000000000000000000000000007844710356333185 Scatter Plot
Source MHC-II Target ANGPT ANGPT Secreted Signaling 0.5301 0.00000000000000000000000000000000000013681317181782655 Scatter Plot
Source MHC-II Target BSP BSP ECM-Receptor 0.5333 0.0000000000000000000000000000000000000425417815893851 Scatter Plot
Source MHC-II Target DMP1 DMP1 ECM-Receptor 0.5364 0.000000000000000000000000000000000000013392114886409915 Scatter Plot
Source MHC-II Target NPR2 NPR2 Secreted Signaling 0.5367 0.000000000000000000000000000000000000011877374718067832 Scatter Plot
Source MHC-II Target NRG NRG Secreted Signaling 0.5378 0.000000000000000000000000000000000000007658340276476197 Scatter Plot
Source MHC-II Target CDH CDH Cell-Cell Contact 0.5506 0.0000000000000000000000000000000000000000551213721017887 Scatter Plot
Source MHC-II Source LCK LCK Cell-Cell Contact 0.5521 0.000000000000000000000000000000000000000030408797353806875 Scatter Plot
Source MHC-II Target PARs PARs Secreted Signaling 0.5558 0.000000000000000000000000000000000000000006953512488332842 Scatter Plot
Source MHC-II Target CD22 CD22 Cell-Cell Contact 0.5611 0.0000000000000000000000000000000000000000007938536296697809 Scatter Plot
Source MHC-II Source ICAM ICAM Cell-Cell Contact 0.5663 0.00000000000000000000000000000000000000000009340850275978002 Scatter Plot
Source MHC-II Target IGF IGF Secreted Signaling 0.5712 0.00000000000000000000000000000000000000000001174479369677535 Scatter Plot
Source MHC-II Source MK MK Secreted Signaling 0.5855 0.000000000000000000000000000000000000000000000023625919279012357 Scatter Plot
Source MHC-II Target KIT KIT Secreted Signaling 0.5875 0.00000000000000000000000000000000000000000000000944799364486924 Scatter Plot
Source MHC-II Target TGFb TGFb Secreted Signaling 0.5905 0.00000000000000000000000000000000000000000000000246039007012384 Scatter Plot
Source MHC-II Target BAFF BAFF Secreted Signaling 0.6123 0.0000000000000000000000000000000000000000000000000000864320298086405 Scatter Plot
Source MHC-II Source CD86 CD86 Cell-Cell Contact 0.6154 0.000000000000000000000000000000000000000000000000000018837810051978882 Scatter Plot
Source MHC-II Target JAM JAM Cell-Cell Contact 0.6316 0.0000000000000000000000000000000000000000000000000000000048555166543483454 Scatter Plot
Source MHC-II Source SEMA7 SEMA7 Cell-Cell Contact 0.6463 0.0000000000000000000000000000000000000000000000000000000000017401860027320954 Scatter Plot
Source MHC-II Target TENASCIN TENASCIN ECM-Receptor 0.6511 0.0000000000000000000000000000000000000000000000000000000000001167676603577108 Scatter Plot
Source MHC-II Target FGF FGF Secreted Signaling 0.6601 0.0000000000000000000000000000000000000000000000000000000000000006468058187346374 Scatter Plot
Source MHC-II Target SEMA4 SEMA4 Cell-Cell Contact 0.6612 0.00000000000000000000000000000000000000000000000000000000000000034721309494030536 Scatter Plot
Source MHC-II Target CD34 CD34 Cell-Cell Contact 0.6629 0.00000000000000000000000000000000000000000000000000000000000000012581675275438928 Scatter Plot
Source MHC-II Source IL7 IL7 Secreted Signaling 0.6854 0.00000000000000000000000000000000000000000000000000000000000000000000012056390363701958 Scatter Plot
Source MHC-II Source BST2 BST2 Cell-Cell Contact 0.6875 0.00000000000000000000000000000000000000000000000000000000000000000000003062234653223055 Scatter Plot
Source MHC-II Target CD200 CD200 Cell-Cell Contact 0.6878 0.00000000000000000000000000000000000000000000000000000000000000000000002421037799295373 Scatter Plot
Source MHC-II Target ESAM ESAM Cell-Cell Contact 0.6964 0.00000000000000000000000000000000000000000000000000000000000000000000000008094781086402636 Scatter Plot
Source MHC-II Target WNT WNT Secreted Signaling 0.7069 0.000000000000000000000000000000000000000000000000000000000000000000000000000059849664252910755 Scatter Plot
Source MHC-II Target SLURP SLURP Secreted Signaling 0.7138 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004229157349860617 Scatter Plot
Source MHC-II Target ncWNT ncWNT Secreted Signaling 0.7143 0.00000000000000000000000000000000000000000000000000000000000000000000000000000028446256148304077 Scatter Plot
Source MHC-II Target CD39 CD39 Cell-Cell Contact 0.7370 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008344813534053075 Scatter Plot
Source MHC-II Target APP APP Cell-Cell Contact 0.7922 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005901729234328215 Scatter Plot
Source MHC-II Target MIF MIF Secreted Signaling 0.8307 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007546532095500627 Scatter Plot
Source MHC-II Source MHC-I MHC-I Cell-Cell Contact 0.8842 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006218987578633271 Scatter Plot
Source MHC-II Source COMPLEMENT COMPLEMENT Secreted Signaling -0.5474 0.00000000000000000000000000000000000000018915558348875723 Scatter Plot
Source MHC-II Target ICAM ICAM Cell-Cell Contact -0.4202 0.00000000000000000000008161216510278765 Scatter Plot
Source MHC-II Source PARs PARs Secreted Signaling -0.4021 0.000000000000000000007359428452815773 Scatter Plot
Source MHC-II Target VCAM VCAM Cell-Cell Contact -0.3954 0.000000000000000000036636733004763505 Scatter Plot
Source MHC-II Target CD52 CD52 Cell-Cell Contact -0.3928 0.00000000000000000006674346884407116 Scatter Plot
Source MHC-II Target CSF CSF Secreted Signaling -0.3257 0.00000000000008016270717455371 Scatter Plot
Source MHC-II Target CEACAM CEACAM Cell-Cell Contact -0.3190 0.0000000000002710023768560123 Scatter Plot
Source MHC-II Target CCL CCL Secreted Signaling -0.2790 0.00000000021705075771439467 Scatter Plot
Source MHC-II Target CXCL CXCL Secreted Signaling -0.2680 0.0000000011267888464992503 Scatter Plot
Source MHC-II Target CLEC CLEC Cell-Cell Contact -0.2675 0.0000000012092265526741816 Scatter Plot
Source MHC-II Source CLEC CLEC Cell-Cell Contact -0.2663 0.0000000014595416304341295 Scatter Plot
Source MHC-II Target IFN-II IFN-II Secreted Signaling -0.2459 0.000000025374563171420665 Scatter Plot
Source MHC-II Target IL17 IL17 Secreted Signaling -0.2336 0.00000012596594588344326 Scatter Plot
Source MHC-II Target VEGF VEGF Secreted Signaling -0.2143 0.0000013187270286605262 Scatter Plot
Source MHC-II Target ANNEXIN ANNEXIN Secreted Signaling -0.1962 0.000009954898128318994 Scatter Plot
Source MHC-II Target COLLAGEN COLLAGEN ECM-Receptor -0.1616 0.0002839970151638 Scatter Plot
Source MHC-II Source ANNEXIN ANNEXIN Secreted Signaling -0.1541 0.0005426329987022 Scatter Plot
Source MHC-II Source NKG2D NKG2D Cell-Cell Contact -0.1288 0.0039253014546425 Scatter Plot
Source MHC-II Target GRN GRN Secreted Signaling -0.1182 0.0081267961580021 Scatter Plot
Source MHC-II Target SEMA3 SEMA3 Secreted Signaling -0.1061 0.0176654797663264 Scatter Plot
Source MHC-II Target COMPLEMENT COMPLEMENT Secreted Signaling -0.0976 0.0291643661019961 Scatter Plot

Cells that are targets of MHC-II from HSCs*

Cells that are source of MHC-II to HSCs*

    No cell populations

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.