Pathway: BSP

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: ECM-Receptor

Details on the BSP pathway:

Specificity Index HSPC as target: 0.271
HSPC as source: 0.781

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the BSP pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target BSP Source APELIN APELIN Secreted Signaling 0.1064 0.0173197240283791 Scatter Plot
Target BSP Source THBS THBS ECM-Receptor 0.1194 0.007512645181894 Scatter Plot
Target BSP Source IL6 IL6 Secreted Signaling 0.1239 0.0055290645076575 Scatter Plot
Target BSP Source GDF GDF Secreted Signaling 0.1340 0.0026812377058285 Scatter Plot
Target BSP Source ANGPTL ANGPTL Secreted Signaling 0.1380 0.0019893228537243 Scatter Plot
Target BSP Source SEMA6 SEMA6 Cell-Cell Contact 0.1389 0.0018536486937147 Scatter Plot
Target BSP Source WNT WNT Secreted Signaling 0.1505 0.0007331865907152 Scatter Plot
Target BSP Source GP1BA GP1BA Cell-Cell Contact 0.1571 0.000423216761902 Scatter Plot
Target BSP Source PTN PTN Secreted Signaling 0.1722 0.0001091807260993 Scatter Plot
Target BSP Source VCAM VCAM Cell-Cell Contact 0.1814 0.00004521102546130109 Scatter Plot
Target BSP Source CD1D2 CD1D2 Cell-Cell Contact 0.1835 0.00003644580222881266 Scatter Plot
Target BSP Target VEGF VEGF Secreted Signaling 0.2011 0.000005852101929387528 Scatter Plot
Target BSP Target GDF GDF Secreted Signaling 0.2051 0.00000375630390811066 Scatter Plot
Target BSP Target NCAM NCAM Cell-Cell Contact 0.2112 0.0000018822167631231108 Scatter Plot
Target BSP Target SEMA3 SEMA3 Secreted Signaling 0.2183 0.0000008227926887913911 Scatter Plot
Target BSP Source CD39 CD39 Cell-Cell Contact 0.2386 0.00000006680144381934787 Scatter Plot
Target BSP Source CCL CCL Secreted Signaling 0.2438 0.000000033477946160337176 Scatter Plot
Target BSP Source IL2 IL2 Secreted Signaling 0.2493 0.00000001608781725428023 Scatter Plot
Target BSP Source SEMA3 SEMA3 Secreted Signaling 0.2538 0.000000008653978965893005 Scatter Plot
Target BSP Target MK MK Secreted Signaling 0.2548 0.000000007487201657393225 Scatter Plot
Target BSP Source THY1 THY1 Cell-Cell Contact 0.2578 0.0000000049460688651968924 Scatter Plot
Target BSP Source ncWNT ncWNT Secreted Signaling 0.2625 0.00000000250396185629178 Scatter Plot
Target BSP Source EPHB EPHB Cell-Cell Contact 0.2801 0.00000000018261680908390504 Scatter Plot
Target BSP Source IL16 IL16 Secreted Signaling 0.2847 0.00000000008887247780851916 Scatter Plot
Target BSP Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2884 0.000000000049446010270148256 Scatter Plot
Target BSP Source RANKL RANKL Secreted Signaling 0.2936 0.000000000021222280473620416 Scatter Plot
Target BSP Target KIT KIT Secreted Signaling 0.2959 0.000000000014481710864704531 Scatter Plot
Target BSP Target SEMA7 SEMA7 Cell-Cell Contact 0.3004 0.000000000006877165887924046 Scatter Plot
Target BSP Source CADM CADM Cell-Cell Contact 0.3046 0.000000000003407125865924579 Scatter Plot
Target BSP Source NOTCH NOTCH Cell-Cell Contact 0.3060 0.0000000000026542618686430398 Scatter Plot
Target BSP Source CD46 CD46 Cell-Cell Contact 0.3141 0.0000000000006477086550605603 Scatter Plot
Target BSP Source NT NT Secreted Signaling 0.3188 0.00000000000028323897707736336 Scatter Plot
Target BSP Source VEGF VEGF Secreted Signaling 0.3204 0.0000000000002114864174997969 Scatter Plot
Target BSP Source CSF CSF Secreted Signaling 0.3348 0.000000000000014529663777572712 Scatter Plot
Target BSP Source CD86 CD86 Cell-Cell Contact 0.3403 0.00000000000000501366530828949 Scatter Plot
Target BSP Source CXCL CXCL Secreted Signaling 0.3443 0.000000000000002321379710828377 Scatter Plot
Target BSP Source LIGHT LIGHT Secreted Signaling 0.3479 0.0000000000000011298093920472808 Scatter Plot
Target BSP Target ACTIVIN ACTIVIN Secreted Signaling 0.3530 0.00000000000000040071798128862298 Scatter Plot
Target BSP Target PARs PARs Secreted Signaling 0.3583 0.000000000000000134417966364344 Scatter Plot
Target BSP Source IGF IGF Secreted Signaling 0.3714 0.000000000000000008402321363108928 Scatter Plot
Target BSP Source ICAM ICAM Cell-Cell Contact 0.3739 0.000000000000000004880928358744291 Scatter Plot
Target BSP Source LCK LCK Cell-Cell Contact 0.3747 0.0000000000000000041296783052242885 Scatter Plot
Target BSP Source CD45 CD45 Cell-Cell Contact 0.3748 0.00000000000000000403367001895198 Scatter Plot
Target BSP Source CX3C CX3C Secreted Signaling 0.3782 0.0000000000000000018988393721844423 Scatter Plot
Target BSP Source FLT3 FLT3 Secreted Signaling 0.3854 0.00000000000000000037264940463319953 Scatter Plot
Target BSP Target BMP BMP Secreted Signaling 0.3878 0.0000000000000000002170754502086898 Scatter Plot
Target BSP Source LAMININ LAMININ ECM-Receptor 0.3988 0.000000000000000000016307088483426493 Scatter Plot
Target BSP Source PROS PROS Secreted Signaling 0.3992 0.000000000000000000014873586956976805 Scatter Plot
Target BSP Source BST2 BST2 Cell-Cell Contact 0.4015 0.000000000000000000008617349437460361 Scatter Plot
Target BSP Source PSAP PSAP Secreted Signaling 0.4344 0.000000000000000000000001982982188057845 Scatter Plot
Target BSP Source MK MK Secreted Signaling 0.4394 0.000000000000000000000000502777801233526 Scatter Plot
Target BSP Target SLURP SLURP Secreted Signaling 0.4409 0.0000000000000000000000003321874804373722 Scatter Plot
Target BSP Source CDH CDH Cell-Cell Contact 0.4516 0.000000000000000000000000016824475413283254 Scatter Plot
Target BSP Source COLLAGEN COLLAGEN ECM-Receptor 0.4539 0.000000000000000000000000008677306810774688 Scatter Plot
Target BSP Source PDGF PDGF Secreted Signaling 0.4562 0.000000000000000000000000004524430894079957 Scatter Plot
Target BSP Source LIFR LIFR Secreted Signaling 0.4580 0.000000000000000000000000002667174298044998 Scatter Plot
Target BSP Source IL7 IL7 Secreted Signaling 0.4733 0.000000000000000000000000000027519671544431367 Scatter Plot
Target BSP Target FGF FGF Secreted Signaling 0.4912 0.0000000000000000000000000000000997824246758388 Scatter Plot
Target BSP Source SEMA7 SEMA7 Cell-Cell Contact 0.4965 0.000000000000000000000000000000017083586589820672 Scatter Plot
Target BSP Source ANGPT ANGPT Secreted Signaling 0.4988 0.000000000000000000000000000000008009446038612502 Scatter Plot
Target BSP Source BMP BMP Secreted Signaling 0.5064 0.0000000000000000000000000000000006258093472571245 Scatter Plot
Target BSP Target CD39 CD39 Cell-Cell Contact 0.5064 0.0000000000000000000000000000000006155359689442795 Scatter Plot
Target BSP Source GAS GAS Secreted Signaling 0.5211 0.000000000000000000000000000000000003672399872720916 Scatter Plot
Target BSP Target WNT WNT Secreted Signaling 0.5254 0.0000000000000000000000000000000000007757694543397635 Scatter Plot
Target BSP Source TWEAK TWEAK Secreted Signaling 0.5255 0.0000000000000000000000000000000000007349855066872319 Scatter Plot
Target BSP Source MHC-II MHC-II Cell-Cell Contact 0.5333 0.0000000000000000000000000000000000000425417815893851 Scatter Plot
Target BSP Source ESAM ESAM Cell-Cell Contact 0.5408 0.0000000000000000000000000000000000000024778807980739207 Scatter Plot
Target BSP Source MHC-I MHC-I Cell-Cell Contact 0.5428 0.0000000000000000000000000000000000000011367282546310646 Scatter Plot
Target BSP Source JAM JAM Cell-Cell Contact 0.5976 0.00000000000000000000000000000000000000000000000009333069233044178 Scatter Plot
Target BSP Source CD52 CD52 Cell-Cell Contact -0.3855 0.00000000000000000036221373932045424 Scatter Plot
Target BSP Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.3371 0.00000000000000936499843180326 Scatter Plot
Target BSP Source SELL SELL Cell-Cell Contact -0.3163 0.00000000000044126200341281697 Scatter Plot
Target BSP Source COMPLEMENT COMPLEMENT Secreted Signaling -0.2891 0.00000000004402534305007349 Scatter Plot
Target BSP Source TGFb TGFb Secreted Signaling -0.2800 0.00000000018433038586173948 Scatter Plot
Target BSP Source PARs PARs Secreted Signaling -0.2744 0.00000000043348219691571607 Scatter Plot
Target BSP Source CLEC CLEC Cell-Cell Contact -0.2574 0.000000005208990866730989 Scatter Plot
Target BSP Source ANGPTL ANGPTL Secreted Signaling -0.2499 0.000000014675732848384553 Scatter Plot
Target BSP Source MIF MIF Secreted Signaling -0.2445 0.000000030791610674834514 Scatter Plot
Target BSP Source CCL CCL Secreted Signaling -0.1772 0.00006752771578518495 Scatter Plot
Target BSP Source SEMA4 SEMA4 Cell-Cell Contact -0.1629 0.000253347176472 Scatter Plot
Target BSP Source NCAM NCAM Cell-Cell Contact -0.1612 0.0002943789392409 Scatter Plot
Target BSP Source VISTA VISTA Cell-Cell Contact -0.1524 0.0006255428131199 Scatter Plot
Target BSP Source SPP1 SPP1 Secreted Signaling -0.1485 0.0008677187668807 Scatter Plot
Target BSP Source TNF TNF Secreted Signaling -0.1161 0.0093441319324328 Scatter Plot
Target BSP Source NKG2D NKG2D Cell-Cell Contact -0.1156 0.0096867395512598 Scatter Plot
Target BSP Source VISFATIN VISFATIN Secreted Signaling -0.0984 0.0278284055355052 Scatter Plot
Target BSP Target CD86 CD86 Cell-Cell Contact 0.1068 0.0168762405905028 Scatter Plot
Target BSP Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1428 0.0013622513458197 Scatter Plot
Target BSP Target GAS GAS Secreted Signaling 0.1449 0.0011558987677828 Scatter Plot
Target BSP Target GALECTIN GALECTIN Secreted Signaling 0.1457 0.0010830718560073 Scatter Plot
Target BSP Target RANKL RANKL Secreted Signaling 0.1594 0.0003445152360776 Scatter Plot
Target BSP Target AGT AGT Secreted Signaling 0.1893 0.000020305189609543665 Scatter Plot
Target BSP Target EPHA EPHA Cell-Cell Contact 0.2105 0.0000020601251762598712 Scatter Plot
Target BSP Target NODAL NODAL Secreted Signaling 0.2380 0.00000007208075153781566 Scatter Plot
Target BSP Target CSPG4 CSPG4 Cell-Cell Contact 0.2905 0.000000000035352485100007783 Scatter Plot
Target BSP Target IL6 IL6 Secreted Signaling 0.3042 0.000000000003642914251703501 Scatter Plot
Target BSP Target CADM CADM Cell-Cell Contact 0.3046 0.000000000003407125865924579 Scatter Plot
Target BSP Target SEMA5 SEMA5 Cell-Cell Contact 0.3102 0.0000000000012916795419477226 Scatter Plot
Target BSP Target OSM OSM Secreted Signaling 0.3126 0.0000000000008464247866181057 Scatter Plot
Target BSP Target SEMA6 SEMA6 Cell-Cell Contact 0.3148 0.0000000000005719239700946257 Scatter Plot
Target BSP Target EPHB EPHB Cell-Cell Contact 0.3292 0.00000000000004211268283492448 Scatter Plot
Target BSP Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.3443 0.0000000000000023080789329439997 Scatter Plot
Target BSP Target VISFATIN VISFATIN Secreted Signaling 0.3503 0.0000000000000007003121083620668 Scatter Plot
Target BSP Target TGFb TGFb Secreted Signaling 0.3723 0.00000000000000000694768498435803 Scatter Plot
Target BSP Target CD22 CD22 Cell-Cell Contact 0.3748 0.000000000000000004033670018951834 Scatter Plot
Target BSP Target BAFF BAFF Secreted Signaling 0.3799 0.0000000000000000012889258237985498 Scatter Plot
Target BSP Target CD200 CD200 Cell-Cell Contact 0.3919 0.00000000000000000008314075165330791 Scatter Plot
Target BSP Target SEMA4 SEMA4 Cell-Cell Contact 0.3994 0.000000000000000000014131119329200788 Scatter Plot
Target BSP Target BMP BMP Secreted Signaling 0.4050 0.000000000000000000003637870067320029 Scatter Plot
Target BSP Target APP APP Cell-Cell Contact 0.4254 0.0000000000000000000000212030786688241 Scatter Plot
Target BSP Target ANGPT ANGPT Secreted Signaling 0.4364 0.0000000000000000000000011336092969507926 Scatter Plot
Target BSP Target CDH CDH Cell-Cell Contact 0.4516 0.000000000000000000000000016824475413283254 Scatter Plot
Target BSP Target NPR2 NPR2 Secreted Signaling 0.4586 0.000000000000000000000000002229009382096152 Scatter Plot
Target BSP Target ncWNT ncWNT Secreted Signaling 0.4753 0.000000000000000000000000000015014449713894217 Scatter Plot
Target BSP Target MIF MIF Secreted Signaling 0.5066 0.0000000000000000000000000000000005780197392055252 Scatter Plot
Target BSP Target ESAM ESAM Cell-Cell Contact 0.5408 0.0000000000000000000000000000000000000024778807980739207 Scatter Plot
Target BSP Target CD34 CD34 Cell-Cell Contact 0.5414 0.0000000000000000000000000000000000000019752005101244447 Scatter Plot
Target BSP Target ICAM ICAM Cell-Cell Contact -0.3166 0.000000000000417447057765306 Scatter Plot
Target BSP Target CD52 CD52 Cell-Cell Contact -0.2689 0.0000000009946180682416662 Scatter Plot
Target BSP Target VCAM VCAM Cell-Cell Contact -0.2251 0.0000003669029325246554 Scatter Plot
Target BSP Target IFN-II IFN-II Secreted Signaling -0.2186 0.0000008021717088668155 Scatter Plot
Target BSP Target CEACAM CEACAM Cell-Cell Contact -0.1755 0.00007957469970376029 Scatter Plot
Target BSP Target CCL CCL Secreted Signaling -0.1617 0.0002818384519971 Scatter Plot
Target BSP Target VEGF VEGF Secreted Signaling -0.1597 0.0003379673291987 Scatter Plot
Target BSP Target CXCL CXCL Secreted Signaling -0.1543 0.0005370069625946 Scatter Plot
Target BSP Target CSF CSF Secreted Signaling -0.1314 0.0032514889962971 Scatter Plot
Target BSP Target GRN GRN Secreted Signaling -0.1141 0.0106382927098529 Scatter Plot
Target BSP Target IL17 IL17 Secreted Signaling -0.1131 0.0113624881686624 Scatter Plot

Cells that are targets of BSP from HSCs*

    No cell populations

Cells that are source of BSP to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.