Cell-Cell Signaling Value
Pathway: VISTA
Average Signaling Potential
- Edge Color:
- — HSCs as target
- — HSCs as source
Pathway Category: Cell-Cell Contact
Details on the VISTA pathway:
Specificity Index
HSPC as target:
HSPC as source:
Graph Terms:
- Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
- HSC Percent: Proportion of HSCs that interact with the given cell type in the VISTA pathway.
- Node Size: Node size refelcts percent of HSCs interacting
- Node Color: Node color reflects Average Signaling Potential
| Correlation Name | Pathway Name | Pathway Category | Correlation Score | -log10(adj. p-value) | Plot |
|---|---|---|---|---|---|
| Source VISTA Source VISFATIN | VISFATIN | Secreted Signaling | 0.1145 | 0.0103775713717641 | Scatter Plot |
| Source VISTA Source SEMA4 | SEMA4 | Cell-Cell Contact | 0.4762 | 0.000000000000000000000000000011454180287783497 | Scatter Plot |
| Source VISTA Source GRN | GRN | Secreted Signaling | 0.4874 | 0.0000000000000000000000000000003324828821815304 | Scatter Plot |
| Source VISTA Source VCAM | VCAM | Cell-Cell Contact | -0.4709 | 0.0000000000000000000000000000570652553220744 | Scatter Plot |
| Source VISTA Source ANGPT | ANGPT | Secreted Signaling | -0.4678 | 0.0000000000000000000000000001474047608003811 | Scatter Plot |
| Source VISTA Source FGF | FGF | Secreted Signaling | -0.3554 | 0.00000000000000024913170310700584 | Scatter Plot |
| Source VISTA Source EPHB | EPHB | Cell-Cell Contact | -0.3304 | 0.000000000000033622894162743755 | Scatter Plot |
| Source VISTA Source LIFR | LIFR | Secreted Signaling | -0.3204 | 0.00000000000020975670098487761 | Scatter Plot |
| Source VISTA Source ESAM | ESAM | Cell-Cell Contact | -0.3128 | 0.0000000000008251212490295614 | Scatter Plot |
| Source VISTA Source TWEAK | TWEAK | Secreted Signaling | -0.2508 | 0.000000013027776573958292 | Scatter Plot |
| Source VISTA Source VEGF | VEGF | Secreted Signaling | -0.2398 | 0.00000005656941946486474 | Scatter Plot |
| Source VISTA Source CDH | CDH | Cell-Cell Contact | -0.2371 | 0.00000008080540385393749 | Scatter Plot |
| Source VISTA Source GAS | GAS | Secreted Signaling | -0.2124 | 0.000001653567608637234 | Scatter Plot |
| Source VISTA Source BMP | BMP | Secreted Signaling | -0.2113 | 0.0000018790612876394176 | Scatter Plot |
| Source VISTA Source PTN | PTN | Secreted Signaling | -0.1751 | 0.00008271302253222536 | Scatter Plot |
| Source VISTA Source OSM | OSM | Secreted Signaling | -0.1716 | 0.0001148707404027 | Scatter Plot |
| Source VISTA Source GDF | GDF | Secreted Signaling | -0.1624 | 0.0002659508559078 | Scatter Plot |
| Source VISTA Source TGFb | TGFb | Secreted Signaling | -0.1491 | 0.0008231355283808 | Scatter Plot |
| Source VISTA Source CCL | CCL | Secreted Signaling | -0.1456 | 0.0010967404793524 | Scatter Plot |
| Source VISTA Source IL6 | IL6 | Secreted Signaling | -0.1452 | 0.001133946728632 | Scatter Plot |
| Source VISTA Source CD34 | CD34 | Cell-Cell Contact | -0.1442 | 0.0012282833117405 | Scatter Plot |
| Source VISTA Source NT | NT | Secreted Signaling | -0.1242 | 0.0054196896487227 | Scatter Plot |
| Source VISTA Source AGRN | AGRN | ECM-Receptor | -0.1219 | 0.0063425325885652 | Scatter Plot |
| Source VISTA Source CD46 | CD46 | Cell-Cell Contact | -0.1159 | 0.0094968453725689 | Scatter Plot |
| Source VISTA Source PROS | PROS | Secreted Signaling | -0.1099 | 0.0139212533429467 | Scatter Plot |
| Source VISTA Source APELIN | APELIN | Secreted Signaling | -0.1002 | 0.0250503656681393 | Scatter Plot |
| Source VISTA Target CD86 | CD86 | Cell-Cell Contact | 0.1012 | 0.023568131850183 | Scatter Plot |
| Source VISTA Source IL16 | IL16 | Secreted Signaling | 0.1089 | 0.0148208435931771 | Scatter Plot |
| Source VISTA Target LAIR1 | LAIR1 | Cell-Cell Contact | 0.1092 | 0.0145719558085868 | Scatter Plot |
| Source VISTA Target BST2 | BST2 | Cell-Cell Contact | 0.1092 | 0.0145719558085868 | Scatter Plot |
| Source VISTA Target IL6 | IL6 | Secreted Signaling | 0.1159 | 0.0094902528541732 | Scatter Plot |
| Source VISTA Target GRN | GRN | Secreted Signaling | 0.1266 | 0.0045702885607561 | Scatter Plot |
| Source VISTA Target ANGPTL | ANGPTL | Secreted Signaling | 0.1480 | 0.0009034201428693 | Scatter Plot |
| Source VISTA Target SELE | SELE | Cell-Cell Contact | 0.1756 | 0.00007927061581019324 | Scatter Plot |
| Source VISTA Target GALECTIN | GALECTIN | Secreted Signaling | 0.1860 | 0.000028454954019730588 | Scatter Plot |
| Source VISTA Target COLLAGEN | COLLAGEN | ECM-Receptor | 0.2076 | 0.000002837904136999637 | Scatter Plot |
| Source VISTA Target IL1 | IL1 | Secreted Signaling | 0.2124 | 0.0000016530444713409216 | Scatter Plot |
| Source VISTA Target IL17 | IL17 | Secreted Signaling | 0.2271 | 0.00000028419313269121815 | Scatter Plot |
| Source VISTA Source TNF | TNF | Secreted Signaling | 0.2578 | 0.000000004896208536876673 | Scatter Plot |
| Source VISTA Source CCL | CCL | Secreted Signaling | 0.2592 | 0.00000000407052543353568 | Scatter Plot |
| Source VISTA Source CLEC | CLEC | Cell-Cell Contact | 0.2710 | 0.0000000007239356880164517 | Scatter Plot |
| Source VISTA Target CD23 | CD23 | Cell-Cell Contact | 0.2795 | 0.00000000019927885897921412 | Scatter Plot |
| Source VISTA Target ANNEXIN | ANNEXIN | Secreted Signaling | 0.2803 | 0.00000000017715943066462875 | Scatter Plot |
| Source VISTA Target VEGF | VEGF | Secreted Signaling | 0.2837 | 0.00000000010298405639464304 | Scatter Plot |
| Source VISTA Target NCAM | NCAM | Cell-Cell Contact | 0.2874 | 0.00000000005822273540327039 | Scatter Plot |
| Source VISTA Target THY1 | THY1 | Cell-Cell Contact | 0.2990 | 0.000000000008739242435464967 | Scatter Plot |
| Source VISTA Source LAIR1 | LAIR1 | Cell-Cell Contact | 0.3141 | 0.0000000000006495089158466372 | Scatter Plot |
| Source VISTA Source BAFF | BAFF | Secreted Signaling | 0.3149 | 0.0000000000005684261409398165 | Scatter Plot |
| Source VISTA Target CXCL | CXCL | Secreted Signaling | 0.3156 | 0.0000000000004977591425578837 | Scatter Plot |
| Source VISTA Target SEMA3 | SEMA3 | Secreted Signaling | 0.3591 | 0.00000000000000011594542251620422 | Scatter Plot |
| Source VISTA Target SELPLG | SELPLG | Cell-Cell Contact | 0.3628 | 0.000000000000000052769836656387 | Scatter Plot |
| Source VISTA Source SPP1 | SPP1 | Secreted Signaling | 0.3771 | 0.000000000000000002434206756453688 | Scatter Plot |
| Source VISTA Target CSF | CSF | Secreted Signaling | 0.4007 | 0.000000000000000000010287569323978144 | Scatter Plot |
| Source VISTA Target COMPLEMENT | COMPLEMENT | Secreted Signaling | 0.4030 | 0.0000000000000000000059256579757467176 | Scatter Plot |
| Source VISTA Source NCAM | NCAM | Cell-Cell Contact | 0.4074 | 0.000000000000000000002059699915329437 | Scatter Plot |
| Source VISTA Source ITGAL-ITGB2 | ITGAL-ITGB2 | Cell-Cell Contact | 0.4160 | 0.00000000000000000000023911319566074315 | Scatter Plot |
| Source VISTA Target CCL | CCL | Secreted Signaling | 0.4180 | 0.00000000000000000000014459329606244007 | Scatter Plot |
| Source VISTA Target VCAM | VCAM | Cell-Cell Contact | 0.4409 | 0.0000000000000000000000003348177086182008 | Scatter Plot |
| Source VISTA Target CLEC | CLEC | Cell-Cell Contact | 0.4430 | 0.00000000000000000000000018668116596630568 | Scatter Plot |
| Source VISTA Target CEACAM | CEACAM | Cell-Cell Contact | 0.4515 | 0.000000000000000000000000017497422394575132 | Scatter Plot |
| Source VISTA Target ICAM | ICAM | Cell-Cell Contact | 0.4603 | 0.0000000000000000000000000013734514268081062 | Scatter Plot |
| Source VISTA Target IFN-II | IFN-II | Secreted Signaling | 0.4627 | 0.00000000000000000000000000066631567494482565 | Scatter Plot |
| Source VISTA Source PARs | PARs | Secreted Signaling | 0.5046 | 0.0000000000000000000000000000000011431696114621932 | Scatter Plot |
| Source VISTA Target CD52 | CD52 | Cell-Cell Contact | 0.5310 | 0.00000000000000000000000000000000000009963392786904655 | Scatter Plot |
| Source VISTA Source SELL | SELL | Cell-Cell Contact | 0.5616 | 0.000000000000000000000000000000000000000000659513580838682 | Scatter Plot |
| Source VISTA Source CD52 | CD52 | Cell-Cell Contact | 0.5650 | 0.00000000000000000000000000000000000000000015939372339506666 | Scatter Plot |
| Source VISTA Source APP | APP | Cell-Cell Contact | 0.5812 | 0.00000000000000000000000000000000000000000000015554920455758344 | Scatter Plot |
| Source VISTA Source ANNEXIN | ANNEXIN | Secreted Signaling | 0.5970 | 0.0000000000000000000000000000000000000000000000001269597544644549 | Scatter Plot |
| Source VISTA Source COMPLEMENT | COMPLEMENT | Secreted Signaling | 0.6273 | 0.00000000000000000000000000000000000000000000000000000004423992105950259 | Scatter Plot |
| Source VISTA Source GALECTIN | GALECTIN | Secreted Signaling | -0.5958 | 0.00000000000000000000000000000000000000000000000022085850081444786 | Scatter Plot |
| Source VISTA Target MK | MK | Secreted Signaling | -0.5847 | 0.00000000000000000000000000000000000000000000003291960295931786 | Scatter Plot |
| Source VISTA Target PARs | PARs | Secreted Signaling | -0.5452 | 0.0000000000000000000000000000000000000004613241784841442 | Scatter Plot |
| Source VISTA Target KIT | KIT | Secreted Signaling | -0.4997 | 0.000000000000000000000000000000005930814616840541 | Scatter Plot |
| Source VISTA Target PTN | PTN | Secreted Signaling | -0.4620 | 0.0000000000000000000000000008324433622052765 | Scatter Plot |
| Source VISTA Target SEMA7 | SEMA7 | Cell-Cell Contact | -0.4326 | 0.0000000000000000000000031556417596960964 | Scatter Plot |
| Source VISTA Source MHC-I | MHC-I | Cell-Cell Contact | -0.4221 | 0.000000000000000000000050538792271143713 | Scatter Plot |
| Source VISTA Source VCAM | VCAM | Cell-Cell Contact | -0.4068 | 0.00000000000000000000233909406379674 | Scatter Plot |
| Source VISTA Target SPP1 | SPP1 | Secreted Signaling | -0.3749 | 0.000000000000000003909313586315506 | Scatter Plot |
| Source VISTA Source MHC-II | MHC-II | Cell-Cell Contact | -0.3605 | 0.00000000000000008536301336175583 | Scatter Plot |
| Source VISTA Target VWF | VWF | ECM-Receptor | -0.3592 | 0.0000000000000001133816469397855 | Scatter Plot |
| Source VISTA Target IGF | IGF | Secreted Signaling | -0.3561 | 0.00000000000000021240979208789502 | Scatter Plot |
| Source VISTA Target FN1 | FN1 | ECM-Receptor | -0.3501 | 0.0000000000000007286166263366936 | Scatter Plot |
| Source VISTA Target WNT | WNT | Secreted Signaling | -0.3400 | 0.000000000000005361080458937455 | Scatter Plot |
| Source VISTA Target CD39 | CD39 | Cell-Cell Contact | -0.3378 | 0.000000000000008193389658652198 | Scatter Plot |
| Source VISTA Target TENASCIN | TENASCIN | ECM-Receptor | -0.3307 | 0.00000000000003191849753374103 | Scatter Plot |
| Source VISTA Source LCK | LCK | Cell-Cell Contact | -0.3282 | 0.000000000000050712895131383997 | Scatter Plot |
| Source VISTA Source COLLAGEN | COLLAGEN | ECM-Receptor | -0.3276 | 0.000000000000056363331487650896 | Scatter Plot |
| Source VISTA Source FLT3 | FLT3 | Secreted Signaling | -0.3239 | 0.00000000000011104604718135809 | Scatter Plot |
| Source VISTA Source GP1BA | GP1BA | Cell-Cell Contact | -0.3190 | 0.0000000000002706987469682144 | Scatter Plot |
| Source VISTA Target SEMA4 | SEMA4 | Cell-Cell Contact | -0.3158 | 0.0000000000004805974983784333 | Scatter Plot |
| Source VISTA Target ESAM | ESAM | Cell-Cell Contact | -0.3128 | 0.0000000000008251212490295614 | Scatter Plot |
| Source VISTA Target ncWNT | ncWNT | Secreted Signaling | -0.3119 | 0.0000000000009587429230777297 | Scatter Plot |
| Source VISTA Source JAM | JAM | Cell-Cell Contact | -0.3021 | 0.000000000005172406692079339 | Scatter Plot |
| Source VISTA Target CD34 | CD34 | Cell-Cell Contact | -0.2943 | 0.000000000018904423628098128 | Scatter Plot |
| Source VISTA Target VTN | VTN | ECM-Receptor | -0.2919 | 0.000000000028010806985909217 | Scatter Plot |
| Source VISTA Target TGFb | TGFb | Secreted Signaling | -0.2854 | 0.00000000007940750405502817 | Scatter Plot |
| Source VISTA Target ANGPT | ANGPT | Secreted Signaling | -0.2816 | 0.00000000014447318692707028 | Scatter Plot |
| Source VISTA Target PDGF | PDGF | Secreted Signaling | -0.2726 | 0.000000000573314761689912 | Scatter Plot |
| Source VISTA Source CXCL | CXCL | Secreted Signaling | -0.2657 | 0.0000000015923672640844755 | Scatter Plot |
| Source VISTA Target FGF | FGF | Secreted Signaling | -0.2590 | 0.000000004170404673977546 | Scatter Plot |
| Source VISTA Target EPHB | EPHB | Cell-Cell Contact | -0.2583 | 0.00000000461127720419189 | Scatter Plot |
| Source VISTA Target LAMININ | LAMININ | ECM-Receptor | -0.2578 | 0.000000004947867385095534 | Scatter Plot |
| Source VISTA Source THY1 | THY1 | Cell-Cell Contact | -0.2466 | 0.00000002323307430842021 | Scatter Plot |
| Source VISTA Source BST2 | BST2 | Cell-Cell Contact | -0.2380 | 0.00000007220880190029206 | Scatter Plot |
| Source VISTA Target CDH | CDH | Cell-Cell Contact | -0.2371 | 0.00000008080540385393749 | Scatter Plot |
| Source VISTA Source IL7 | IL7 | Secreted Signaling | -0.2345 | 0.0000001126549965590531 | Scatter Plot |
| Source VISTA Target ITGAL-ITGB2 | ITGAL-ITGB2 | Cell-Cell Contact | -0.2294 | 0.00000021539094824666557 | Scatter Plot |
| Source VISTA Source SEMA4 | SEMA4 | Cell-Cell Contact | -0.2279 | 0.0000002597427569632764 | Scatter Plot |
| Source VISTA Target SLURP | SLURP | Secreted Signaling | -0.2237 | 0.00000043169322020455486 | Scatter Plot |
| Source VISTA Target JAM | JAM | Cell-Cell Contact | -0.2231 | 0.00000046601377478882046 | Scatter Plot |
| Source VISTA Target SEMA5 | SEMA5 | Cell-Cell Contact | -0.2209 | 0.0000006064577631878319 | Scatter Plot |
| Source VISTA Target THBS | THBS | ECM-Receptor | -0.2125 | 0.000001637985705061578 | Scatter Plot |
| Source VISTA Target SEMA6 | SEMA6 | Cell-Cell Contact | -0.2016 | 0.000005511131590590593 | Scatter Plot |
| Source VISTA Target VISFATIN | VISFATIN | Secreted Signaling | -0.1979 | 0.000008271894232489871 | Scatter Plot |
| Source VISTA Target APP | APP | Cell-Cell Contact | -0.1950 | 0.000011240709004355435 | Scatter Plot |
| Source VISTA Source ICAM | ICAM | Cell-Cell Contact | -0.1930 | 0.000013865890951717898 | Scatter Plot |
| Source VISTA Source CD86 | CD86 | Cell-Cell Contact | -0.1810 | 0.00004673504650396455 | Scatter Plot |
| Source VISTA Target NRG | NRG | Secreted Signaling | -0.1794 | 0.000054750416223732485 | Scatter Plot |
| Source VISTA Source SEMA7 | SEMA7 | Cell-Cell Contact | -0.1790 | 0.00005710946127129224 | Scatter Plot |
| Source VISTA Source IL2 | IL2 | Secreted Signaling | -0.1755 | 0.00008006092086262997 | Scatter Plot |
| Source VISTA Target ACTIVIN | ACTIVIN | Secreted Signaling | -0.1728 | 0.0001030273600882 | Scatter Plot |
| Source VISTA Source CD1D2 | CD1D2 | Cell-Cell Contact | -0.1715 | 0.0001157806716422 | Scatter Plot |
| Source VISTA Target DMP1 | DMP1 | ECM-Receptor | -0.1696 | 0.0001390981768575 | Scatter Plot |
| Source VISTA Target AGT | AGT | Secreted Signaling | -0.1663 | 0.000187659150198 | Scatter Plot |
| Source VISTA Target MIF | MIF | Secreted Signaling | -0.1624 | 0.0002646442102649 | Scatter Plot |
| Source VISTA Target ANGPTL | ANGPTL | Secreted Signaling | -0.1585 | 0.0003753748863367 | Scatter Plot |
| Source VISTA Source ANGPTL | ANGPTL | Secreted Signaling | -0.1571 | 0.0004230099201482 | Scatter Plot |
| Source VISTA Target VEGF | VEGF | Secreted Signaling | -0.1557 | 0.0004763684986382 | Scatter Plot |
| Source VISTA Source PDGF | PDGF | Secreted Signaling | -0.1547 | 0.0005157576206308 | Scatter Plot |
| Source VISTA Target BSP | BSP | ECM-Receptor | -0.1524 | 0.0006255428131199 | Scatter Plot |
| Source VISTA Target NOTCH | NOTCH | Cell-Cell Contact | -0.1521 | 0.0006446013337483 | Scatter Plot |
| Source VISTA Target BMP | BMP | Secreted Signaling | -0.1516 | 0.0006683820101206 | Scatter Plot |
| Source VISTA Source MK | MK | Secreted Signaling | -0.1515 | 0.0006777277352855 | Scatter Plot |
| Source VISTA Target SELL | SELL | Cell-Cell Contact | -0.1499 | 0.0007706444790928 | Scatter Plot |
| Source VISTA Target TWEAK | TWEAK | Secreted Signaling | -0.1407 | 0.0016110291614926 | Scatter Plot |
| Source VISTA Target PERIOSTIN | PERIOSTIN | Secreted Signaling | -0.1390 | 0.00183420480571 | Scatter Plot |
| Source VISTA Target NPR2 | NPR2 | Secreted Signaling | -0.1367 | 0.0021900347225121 | Scatter Plot |
| Source VISTA Target CSPG4 | CSPG4 | Cell-Cell Contact | -0.1366 | 0.0022077376471289 | Scatter Plot |
| Source VISTA Source CX3C | CX3C | Secreted Signaling | -0.1313 | 0.0032590619439522 | Scatter Plot |
| Source VISTA Source IGF | IGF | Secreted Signaling | -0.1195 | 0.0074794516263244 | Scatter Plot |
| Source VISTA Target GAS | GAS | Secreted Signaling | -0.1143 | 0.0105344454532339 | Scatter Plot |
| Source VISTA Target COLLAGEN | COLLAGEN | ECM-Receptor | -0.1134 | 0.0111792632745609 | Scatter Plot |
| Source VISTA Target ADIPONECTIN | ADIPONECTIN | Secreted Signaling | -0.1066 | 0.0170907475424891 | Scatter Plot |
| Source VISTA Target NODAL | NODAL | Secreted Signaling | -0.1066 | 0.0171237916981421 | Scatter Plot |
| Source VISTA Source IL1 | IL1 | Secreted Signaling | -0.1049 | 0.0189360433977186 | Scatter Plot |
| Source VISTA Target IL1 | IL1 | Secreted Signaling | -0.1033 | 0.0209157320205075 | Scatter Plot |
| Source VISTA Source CSF | CSF | Secreted Signaling | -0.1019 | 0.0226127360700288 | Scatter Plot |
Cells that are targets of VISTA from HSCs*
Cells that are source of VISTA to HSCs*
-
No cell populations
*Cell types are filtered such that they interact with at least 5% of HSCs.