Pathway: SELPLG

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Cell-Cell Contact

Details on the SELPLG pathway:

Specificity Index HSPC as target: 0.611
HSPC as source: 0.529

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the SELPLG pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target SELPLG Target PERIOSTIN PERIOSTIN Secreted Signaling 0.0985 0.0276621209559211 Scatter Plot
Target SELPLG Target GALECTIN GALECTIN Secreted Signaling 0.1006 0.0245433871576661 Scatter Plot
Target SELPLG Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1037 0.0203812722778902 Scatter Plot
Target SELPLG Target AGT AGT Secreted Signaling 0.1052 0.0186600326991083 Scatter Plot
Target SELPLG Source IL16 IL16 Secreted Signaling 0.1066 0.0171272975561857 Scatter Plot
Target SELPLG Source LAMININ LAMININ ECM-Receptor 0.1087 0.0150044259042997 Scatter Plot
Target SELPLG Target CD45 CD45 Cell-Cell Contact 0.1101 0.0137794365221675 Scatter Plot
Target SELPLG Source ICAM ICAM Cell-Cell Contact 0.1111 0.0129585110259744 Scatter Plot
Target SELPLG Target ANGPTL ANGPTL Secreted Signaling 0.1182 0.0081708902806765 Scatter Plot
Target SELPLG Target JAM JAM Cell-Cell Contact 0.1198 0.0073396195816908 Scatter Plot
Target SELPLG Source NOTCH NOTCH Cell-Cell Contact 0.1213 0.0066251503443333 Scatter Plot
Target SELPLG Source TNF TNF Secreted Signaling 0.1222 0.0062210332453574 Scatter Plot
Target SELPLG Source FN1 FN1 ECM-Receptor 0.1226 0.0060719589382435 Scatter Plot
Target SELPLG Source JAM JAM Cell-Cell Contact 0.1226 0.0060644766977643 Scatter Plot
Target SELPLG Source CLEC CLEC Cell-Cell Contact 0.1243 0.0053628812399053 Scatter Plot
Target SELPLG Target COLLAGEN COLLAGEN ECM-Receptor 0.1248 0.0051962004776087 Scatter Plot
Source SELPLG Source SPP1 SPP1 Secreted Signaling 0.1254 0.0049799862137143 Scatter Plot
Target SELPLG Source PROS PROS Secreted Signaling 0.1263 0.0046861687169328 Scatter Plot
Target SELPLG Source PDGF PDGF Secreted Signaling 0.1283 0.0040680160750111 Scatter Plot
Source SELPLG Source OSM OSM Secreted Signaling 0.1336 0.0027546216900826 Scatter Plot
Target SELPLG Source ICOS ICOS Cell-Cell Contact 0.1344 0.0025975851950335 Scatter Plot
Target SELPLG Source LIGHT LIGHT Secreted Signaling 0.1359 0.0023300551088359 Scatter Plot
Target SELPLG Target CADM CADM Cell-Cell Contact 0.1377 0.0020224030370152 Scatter Plot
Target SELPLG Source CADM CADM Cell-Cell Contact 0.1377 0.0020224030370152 Scatter Plot
Target SELPLG Source CSF CSF Secreted Signaling 0.1445 0.0011976888493364 Scatter Plot
Source SELPLG Source PECAM1 PECAM1 Cell-Cell Contact 0.1479 0.0009118964365963 Scatter Plot
Target SELPLG Source PECAM1 PECAM1 Cell-Cell Contact 0.1514 0.00068292812403 Scatter Plot
Target SELPLG Target PECAM1 PECAM1 Cell-Cell Contact 0.1514 0.00068292812403 Scatter Plot
Source SELPLG Source SEMA4 SEMA4 Cell-Cell Contact 0.1595 0.0003419398611304 Scatter Plot
Source SELPLG Source VISFATIN VISFATIN Secreted Signaling 0.1640 0.0002310517496352 Scatter Plot
Target SELPLG Source SEMA6 SEMA6 Cell-Cell Contact 0.1726 0.0001045152481049 Scatter Plot
Target SELPLG Source ANNEXIN ANNEXIN Secreted Signaling 0.1855 0.00003006014659638189 Scatter Plot
Target SELPLG Source BST2 BST2 Cell-Cell Contact 0.1916 0.000016093681355527568 Scatter Plot
Target SELPLG Source COMPLEMENT COMPLEMENT Secreted Signaling 0.1928 0.00001423553281618861 Scatter Plot
Target SELPLG Source SEMA4 SEMA4 Cell-Cell Contact 0.1939 0.000012676330505515771 Scatter Plot
Target SELPLG Target CXCL CXCL Secreted Signaling 0.2040 0.000004263731864171359 Scatter Plot
Target SELPLG Source MIF MIF Secreted Signaling 0.2044 0.000004065030289066744 Scatter Plot
Target SELPLG Target IL17 IL17 Secreted Signaling 0.2091 0.0000024062881795037302 Scatter Plot
Target SELPLG Source VISFATIN VISFATIN Secreted Signaling 0.2120 0.0000017292533876161992 Scatter Plot
Target SELPLG Source CD34 CD34 Cell-Cell Contact 0.2221 0.0000005271245158438085 Scatter Plot
Target SELPLG Target SEMA3 SEMA3 Secreted Signaling 0.2262 0.0000003193445685063552 Scatter Plot
Target SELPLG Target SELL SELL Cell-Cell Contact 0.2293 0.0000002182820310509615 Scatter Plot
Source SELPLG Source CCL CCL Secreted Signaling 0.2299 0.00000020275356886136529 Scatter Plot
Target SELPLG Source NT NT Secreted Signaling 0.2334 0.0000001289658727639727 Scatter Plot
Source SELPLG Source PSAP PSAP Secreted Signaling 0.2335 0.00000012814104405700384 Scatter Plot
Target SELPLG Target CCL CCL Secreted Signaling 0.2362 0.00000009025676508667596 Scatter Plot
Target SELPLG Source SPP1 SPP1 Secreted Signaling 0.2481 0.00000001896717667132629 Scatter Plot
Target SELPLG Source CD52 CD52 Cell-Cell Contact 0.2539 0.000000008458972415358823 Scatter Plot
Target SELPLG Target SEMA4 SEMA4 Cell-Cell Contact 0.2584 0.0000000045097606464674575 Scatter Plot
Source SELPLG Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.2766 0.0000000003106208308337945 Scatter Plot
Target SELPLG Source PSAP PSAP Secreted Signaling 0.2942 0.000000000019122833847110038 Scatter Plot
Target SELPLG Source CCL CCL Secreted Signaling 0.2951 0.00000000001656464451595292 Scatter Plot
Target SELPLG Source PARs PARs Secreted Signaling 0.3006 0.000000000006688549333173969 Scatter Plot
Target SELPLG Source GRN GRN Secreted Signaling 0.3092 0.0000000000015266158974457392 Scatter Plot
Target SELPLG Target CLEC CLEC Cell-Cell Contact 0.3252 0.00000000000008799782985550845 Scatter Plot
Target SELPLG Target IL6 IL6 Secreted Signaling 0.3462 0.0000000000000015821118088794653 Scatter Plot
Target SELPLG Source VISTA VISTA Cell-Cell Contact 0.3628 0.000000000000000052769836656387 Scatter Plot
Source SELPLG Source TGFb TGFb Secreted Signaling 0.3676 0.000000000000000019149148567668705 Scatter Plot
Target SELPLG Source APP APP Cell-Cell Contact 0.4018 0.000000000000000000008008550403968594 Scatter Plot
Source SELPLG Source SELL SELL Cell-Cell Contact 0.4024 0.00000000000000000000685921697361416 Scatter Plot
Target SELPLG Target CSF CSF Secreted Signaling 0.4337 0.0000000000000000000000023458238430693643 Scatter Plot
Source SELPLG Source CD34 CD34 Cell-Cell Contact 0.5822 0.00000000000000000000000000000000000000000000010250020936063027 Scatter Plot
Target SELPLG Source GALECTIN GALECTIN Secreted Signaling -0.3675 0.000000000000000019666628573518005 Scatter Plot
Source SELPLG Source LIFR LIFR Secreted Signaling -0.2660 0.0000000015268565854519366 Scatter Plot
Source SELPLG Source FLT3 FLT3 Secreted Signaling -0.2612 0.000000003049980545356908 Scatter Plot
Target SELPLG Target KIT KIT Secreted Signaling -0.2590 0.000000004173822807562475 Scatter Plot
Source SELPLG Source PDGF PDGF Secreted Signaling -0.2459 0.000000025423696201239807 Scatter Plot
Target SELPLG Target MK MK Secreted Signaling -0.2407 0.00000005078160232398536 Scatter Plot
Target SELPLG Source FGF FGF Secreted Signaling -0.2312 0.0000001713035039338397 Scatter Plot
Source SELPLG Source VEGF VEGF Secreted Signaling -0.2222 0.000000517659197648896 Scatter Plot
Source SELPLG Source BMP BMP Secreted Signaling -0.2162 0.000001055059677177448 Scatter Plot
Target SELPLG Source VCAM VCAM Cell-Cell Contact -0.2123 0.000001658350970786617 Scatter Plot
Source SELPLG Source NOTCH NOTCH Cell-Cell Contact -0.2109 0.000001959987631491152 Scatter Plot
Target SELPLG Source CXCL CXCL Secreted Signaling -0.1923 0.00001498750334162699 Scatter Plot
Source SELPLG Source ESAM ESAM Cell-Cell Contact -0.1890 0.000020920404129857843 Scatter Plot
Target SELPLG Source CCL CCL Secreted Signaling -0.1855 0.00003008034753836792 Scatter Plot
Target SELPLG Source EPHB EPHB Cell-Cell Contact -0.1843 0.00003389899597360411 Scatter Plot
Source SELPLG Source NT NT Secreted Signaling -0.1822 0.00004181088204235781 Scatter Plot
Target SELPLG Target SEMA7 SEMA7 Cell-Cell Contact -0.1809 0.000047322854196646655 Scatter Plot
Target SELPLG Target IL1 IL1 Secreted Signaling -0.1682 0.000157088182055 Scatter Plot
Source SELPLG Source CDH CDH Cell-Cell Contact -0.1619 0.0002770173641968 Scatter Plot
Source SELPLG Source SEMA7 SEMA7 Cell-Cell Contact -0.1538 0.0005580434128438 Scatter Plot
Target SELPLG Target SPP1 SPP1 Secreted Signaling -0.1523 0.0006311595225725 Scatter Plot
Target SELPLG Target FN1 FN1 ECM-Receptor -0.1482 0.0008859917271271 Scatter Plot
Target SELPLG Target IGF IGF Secreted Signaling -0.1480 0.0009012279821292 Scatter Plot
Source SELPLG Source NCAM NCAM Cell-Cell Contact -0.1474 0.0009431540048465 Scatter Plot
Target SELPLG Source VEGF VEGF Secreted Signaling -0.1449 0.0011578886396768 Scatter Plot
Source SELPLG Source CD46 CD46 Cell-Cell Contact -0.1413 0.0015380597933408 Scatter Plot
Source SELPLG Source IGF IGF Secreted Signaling -0.1319 0.0031377029447029 Scatter Plot
Source SELPLG Source TWEAK TWEAK Secreted Signaling -0.1300 0.003598078124973 Scatter Plot
Source SELPLG Source EPHB EPHB Cell-Cell Contact -0.1260 0.0047708614081533 Scatter Plot
Target SELPLG Target COMPLEMENT COMPLEMENT Secreted Signaling -0.1232 0.0057932450996252 Scatter Plot
Source SELPLG Source CADM CADM Cell-Cell Contact -0.1224 0.0061175925925501 Scatter Plot
Target SELPLG Target PTN PTN Secreted Signaling -0.1159 0.009487266922235 Scatter Plot
Target SELPLG Source ANGPTL ANGPTL Secreted Signaling -0.1120 0.0122115227732781 Scatter Plot
Source SELPLG Source PROS PROS Secreted Signaling -0.1114 0.0127172467520858 Scatter Plot
Target SELPLG Source IL1 IL1 Secreted Signaling -0.1029 0.0213889177528614 Scatter Plot
Source SELPLG Source PTN PTN Secreted Signaling -0.1005 0.0246704178705843 Scatter Plot
Source SELPLG Source SEMA3 SEMA3 Secreted Signaling -0.1001 0.0252387873974031 Scatter Plot
Source SELPLG Source CCL CCL Secreted Signaling -0.0988 0.0271710428577729 Scatter Plot
Target SELPLG Source MHC-I MHC-I Cell-Cell Contact -0.0981 0.0282208565543573 Scatter Plot
Source SELPLG Source MHC-I MHC-I Cell-Cell Contact -0.0974 0.0294936858108287 Scatter Plot
Source SELPLG Source IL16 IL16 Secreted Signaling 0.0974 0.0295106140326355 Scatter Plot
Target SELPLG Target THY1 THY1 Cell-Cell Contact 0.1004 0.0247995662353205 Scatter Plot
Source SELPLG Target NODAL NODAL Secreted Signaling 0.1015 0.0232272092327383 Scatter Plot
Source SELPLG Target CD86 CD86 Cell-Cell Contact 0.1069 0.016792165632798 Scatter Plot
Source SELPLG Target BST2 BST2 Cell-Cell Contact 0.1106 0.0133084410273963 Scatter Plot
Source SELPLG Target LAIR1 LAIR1 Cell-Cell Contact 0.1106 0.0133084410273963 Scatter Plot
Source SELPLG Target COLLAGEN COLLAGEN ECM-Receptor 0.1213 0.0065950449034626 Scatter Plot
Source SELPLG Target BAFF BAFF Secreted Signaling 0.1235 0.0056822981337258 Scatter Plot
Source SELPLG Source SPP1 SPP1 Secreted Signaling 0.1254 0.0049810766401314 Scatter Plot
Source SELPLG Target SELE SELE Cell-Cell Contact 0.1254 0.0049801867867975 Scatter Plot
Source SELPLG Target SEMA4 SEMA4 Cell-Cell Contact 0.1280 0.0041588371362977 Scatter Plot
Source SELPLG Target SPP1 SPP1 Secreted Signaling 0.1285 0.0040007948195875 Scatter Plot
Source SELPLG Target GALECTIN GALECTIN Secreted Signaling 0.1370 0.0021310694589279 Scatter Plot
Source SELPLG Source ICAM ICAM Cell-Cell Contact 0.1381 0.0019653108687175 Scatter Plot
Source SELPLG Source FGF FGF Secreted Signaling 0.1386 0.0019003989017644 Scatter Plot
Source SELPLG Source ANNEXIN ANNEXIN Secreted Signaling 0.1453 0.0011225464098011 Scatter Plot
Source SELPLG Source TNF TNF Secreted Signaling 0.1475 0.0009366970715313 Scatter Plot
Source SELPLG Target PECAM1 PECAM1 Cell-Cell Contact 0.1479 0.0009118964365963 Scatter Plot
Source SELPLG Target SEMA3 SEMA3 Secreted Signaling 0.1536 0.0005691055772194 Scatter Plot
Source SELPLG Source ANGPTL ANGPTL Secreted Signaling 0.1589 0.0003599786781112 Scatter Plot
Target SELPLG Target CD86 CD86 Cell-Cell Contact 0.1599 0.0003318111246545 Scatter Plot
Source SELPLG Source FN1 FN1 ECM-Receptor 0.1619 0.0002767730888692 Scatter Plot
Source SELPLG Target TWEAK TWEAK Secreted Signaling 0.1643 0.0002248833342531 Scatter Plot
Source SELPLG Target CXCL CXCL Secreted Signaling 0.1726 0.0001048382786482 Scatter Plot
Source SELPLG Source CLEC CLEC Cell-Cell Contact 0.1802 0.00005063577706965787 Scatter Plot
Target SELPLG Target OSM OSM Secreted Signaling 0.1863 0.000027731427156671148 Scatter Plot
Source SELPLG Source SEMA4 SEMA4 Cell-Cell Contact 0.1865 0.000027026089223232252 Scatter Plot
Target SELPLG Target IFN-II IFN-II Secreted Signaling 0.1975 0.000008625514337387643 Scatter Plot
Target SELPLG Target CD52 CD52 Cell-Cell Contact 0.2069 0.000003083547230148912 Scatter Plot
Source SELPLG Source THY1 THY1 Cell-Cell Contact 0.2144 0.0000013100954536354184 Scatter Plot
Source SELPLG Target CCL CCL Secreted Signaling 0.2213 0.0000005811729235594688 Scatter Plot
Source SELPLG Source VCAM VCAM Cell-Cell Contact 0.2227 0.0000004888523252829681 Scatter Plot
Source SELPLG Target CD52 CD52 Cell-Cell Contact 0.2244 0.00000039615376556398244 Scatter Plot
Target SELPLG Target SELL SELL Cell-Cell Contact 0.2290 0.00000022576645179789258 Scatter Plot
Source SELPLG Source PARs PARs Secreted Signaling 0.2317 0.00000016116209720822606 Scatter Plot
Source SELPLG Target IL17 IL17 Secreted Signaling 0.2407 0.00000005040255564448728 Scatter Plot
Source SELPLG Target ICAM ICAM Cell-Cell Contact 0.2433 0.000000035813518741852536 Scatter Plot
Source SELPLG Target IL6 IL6 Secreted Signaling 0.2497 0.00000001512891685469994 Scatter Plot
Source SELPLG Target PDGF PDGF Secreted Signaling 0.2564 0.0000000060089476426831665 Scatter Plot
Source SELPLG Target IFN-II IFN-II Secreted Signaling 0.2595 0.0000000038635398121463114 Scatter Plot
Source SELPLG Source MIF MIF Secreted Signaling 0.2624 0.000000002541470664308173 Scatter Plot
Target SELPLG Target SEMA4 SEMA4 Cell-Cell Contact 0.2646 0.000000001869797230417064 Scatter Plot
Source SELPLG Target CLEC CLEC Cell-Cell Contact 0.3010 0.000000000006257950223408962 Scatter Plot
Source SELPLG Target CSF CSF Secreted Signaling 0.3632 0.000000000000000048251135033757707 Scatter Plot
Source SELPLG Source CD52 CD52 Cell-Cell Contact 0.4012 0.000000000000000000009282256818755444 Scatter Plot
Source SELPLG Source SELL SELL Cell-Cell Contact 0.4024 0.00000000000000000000685921697361416 Scatter Plot
Source SELPLG Target SELL SELL Cell-Cell Contact 0.5675 0.00000000000000000000000000000000000000000005535286061145537 Scatter Plot
Source SELPLG Target NCAM NCAM Cell-Cell Contact -0.3841 0.000000000000000000502662014450178 Scatter Plot
Source SELPLG Target AGT AGT Secreted Signaling -0.3133 0.0000000000007568258767739694 Scatter Plot
Source SELPLG Target JAM JAM Cell-Cell Contact -0.2567 0.000000005767387879851012 Scatter Plot
Source SELPLG Source BAFF BAFF Secreted Signaling -0.2400 0.00000005514505148921632 Scatter Plot
Source SELPLG Target IGF IGF Secreted Signaling -0.2388 0.00000006512186213962497 Scatter Plot
Source SELPLG Source JAM JAM Cell-Cell Contact -0.2081 0.000002677707872570566 Scatter Plot
Source SELPLG Source RANKL RANKL Secreted Signaling -0.1952 0.00001097621919911261 Scatter Plot
Source SELPLG Target ESAM ESAM Cell-Cell Contact -0.1890 0.000020920404129857843 Scatter Plot
Target SELPLG Target PARs PARs Secreted Signaling -0.1826 0.00003988100483278608 Scatter Plot
Source SELPLG Target VEGF VEGF Secreted Signaling -0.1812 0.00004582345402435469 Scatter Plot
Source SELPLG Target SEMA5 SEMA5 Cell-Cell Contact -0.1785 0.000059681283569587753 Scatter Plot
Source SELPLG Source GP1BA GP1BA Cell-Cell Contact -0.1725 0.0001061407794972 Scatter Plot
Source SELPLG Target TENASCIN TENASCIN ECM-Receptor -0.1703 0.0001305050272507 Scatter Plot
Source SELPLG Target PARs PARs Secreted Signaling -0.1671 0.0001735915243159 Scatter Plot
Source SELPLG Target VWF VWF ECM-Receptor -0.1641 0.0002275733329531 Scatter Plot
Source SELPLG Target CDH CDH Cell-Cell Contact -0.1619 0.0002770173641968 Scatter Plot
Source SELPLG Source CXCL CXCL Secreted Signaling -0.1607 0.0003096250286092 Scatter Plot
Source SELPLG Target NPR2 NPR2 Secreted Signaling -0.1583 0.0003801369755434 Scatter Plot
Source SELPLG Source SEMA7 SEMA7 Cell-Cell Contact -0.1538 0.0005580434128438 Scatter Plot
Target SELPLG Target SPP1 SPP1 Secreted Signaling -0.1533 0.0005836566730435 Scatter Plot
Source SELPLG Target ncWNT ncWNT Secreted Signaling -0.1510 0.000704589155417 Scatter Plot
Source SELPLG Target ANGPT ANGPT Secreted Signaling -0.1478 0.0009157199468189 Scatter Plot
Source SELPLG Target FGF FGF Secreted Signaling -0.1459 0.001070024029188 Scatter Plot
Source SELPLG Target THY1 THY1 Cell-Cell Contact -0.1429 0.0013602178631581 Scatter Plot
Source SELPLG Target CD23 CD23 Cell-Cell Contact -0.1399 0.0017092598635401 Scatter Plot
Source SELPLG Target SEMA7 SEMA7 Cell-Cell Contact -0.1387 0.001876797114789 Scatter Plot
Source SELPLG Target CD34 CD34 Cell-Cell Contact -0.1360 0.0023011387054268 Scatter Plot
Source SELPLG Target SEMA6 SEMA6 Cell-Cell Contact -0.1347 0.002543514766647 Scatter Plot
Source SELPLG Target WNT WNT Secreted Signaling -0.1346 0.0025560192732599 Scatter Plot
Source SELPLG Target ANGPTL ANGPTL Secreted Signaling -0.1343 0.0026254160051916 Scatter Plot
Source SELPLG Target CSPG4 CSPG4 Cell-Cell Contact -0.1341 0.0026502474484907 Scatter Plot
Source SELPLG Target ANNEXIN ANNEXIN Secreted Signaling -0.1253 0.0050183583316689 Scatter Plot
Source SELPLG Target CADM CADM Cell-Cell Contact -0.1224 0.0061175925925502 Scatter Plot
Source SELPLG Target VISFATIN VISFATIN Secreted Signaling -0.1183 0.0080814797820812 Scatter Plot
Source SELPLG Target BMP BMP Secreted Signaling -0.1158 0.0095402081797916 Scatter Plot
Source SELPLG Target THBS THBS ECM-Receptor -0.1072 0.0165038548211723 Scatter Plot
Source SELPLG Source GAS GAS Secreted Signaling -0.1069 0.0167647968558656 Scatter Plot
Source SELPLG Target PTN PTN Secreted Signaling -0.1036 0.0205589417286579 Scatter Plot
Source SELPLG Source SEMA3 SEMA3 Secreted Signaling -0.1001 0.0252387873974031 Scatter Plot

Cells that are targets of SELPLG from HSCs*

Cells that are source of SELPLG to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.