Pathway: SEMA4

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Cell-Cell Contact

Details on the SEMA4 pathway:

Specificity Index HSPC as target: 0.361
HSPC as source: 0.324

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the SEMA4 pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target SEMA4 Source SEMA6 SEMA6 Cell-Cell Contact 0.1073 0.016366437739141 Scatter Plot
Target SEMA4 Source GP1BA GP1BA Cell-Cell Contact 0.1096 0.0141917807886758 Scatter Plot
Source SEMA4 Source VEGF VEGF Secreted Signaling 0.1134 0.0111433798102404 Scatter Plot
Target SEMA4 Target CSF CSF Secreted Signaling 0.1170 0.0088320186329887 Scatter Plot
Target SEMA4 Target GAS GAS Secreted Signaling 0.1174 0.0085822126442381 Scatter Plot
Source SEMA4 Source VISFATIN VISFATIN Secreted Signaling 0.1231 0.0058386919526748 Scatter Plot
Source SEMA4 Source PTN PTN Secreted Signaling 0.1233 0.0057632653383461 Scatter Plot
Target SEMA4 Source SELPLG SELPLG Cell-Cell Contact 0.1280 0.0041588371362977 Scatter Plot
Target SEMA4 Source IL6 IL6 Secreted Signaling 0.1287 0.0039316971387302 Scatter Plot
Source SEMA4 Source OSM OSM Secreted Signaling 0.1307 0.0034117555063043 Scatter Plot
Target SEMA4 Source OSM OSM Secreted Signaling 0.1309 0.0033738681694092 Scatter Plot
Target SEMA4 Target CD23 CD23 Cell-Cell Contact 0.1317 0.0031741255467087 Scatter Plot
Source SEMA4 Source SEMA6 SEMA6 Cell-Cell Contact 0.1328 0.0029228918551414 Scatter Plot
Target SEMA4 Target PDGF PDGF Secreted Signaling 0.1366 0.0021964281485588 Scatter Plot
Target SEMA4 Source ICOS ICOS Cell-Cell Contact 0.1388 0.0018686369374973 Scatter Plot
Target SEMA4 Target CCL CCL Secreted Signaling 0.1436 0.0012789222429102 Scatter Plot
Target SEMA4 Target TWEAK TWEAK Secreted Signaling 0.1463 0.0010313640661749 Scatter Plot
Target SEMA4 Source GRN GRN Secreted Signaling 0.1525 0.0006214792519803 Scatter Plot
Target SEMA4 Source ncWNT ncWNT Secreted Signaling 0.1564 0.0004490302159411 Scatter Plot
Source SEMA4 Source CD34 CD34 Cell-Cell Contact 0.1572 0.000419364082716 Scatter Plot
Source SEMA4 Source FGF FGF Secreted Signaling 0.1572 0.0004167973474557 Scatter Plot
Target SEMA4 Target AGT AGT Secreted Signaling 0.1599 0.0003298775326554 Scatter Plot
Target SEMA4 Source GALECTIN GALECTIN Secreted Signaling 0.1609 0.0003040802002043 Scatter Plot
Source SEMA4 Source VCAM VCAM Cell-Cell Contact 0.1622 0.0002701641269023 Scatter Plot
Target SEMA4 Target RANKL RANKL Secreted Signaling 0.1659 0.0001952069184343 Scatter Plot
Target SEMA4 Source FN1 FN1 ECM-Receptor 0.1736 0.00009540491952910756 Scatter Plot
Target SEMA4 Target NOTCH NOTCH Cell-Cell Contact 0.1791 0.000056639910620598455 Scatter Plot
Target SEMA4 Source SEMA3 SEMA3 Secreted Signaling 0.1839 0.00003517458684709155 Scatter Plot
Source SEMA4 Source SELPLG SELPLG Cell-Cell Contact 0.1865 0.000027026089223232252 Scatter Plot
Target SEMA4 Target GALECTIN GALECTIN Secreted Signaling 0.1925 0.000014661908907868623 Scatter Plot
Target SEMA4 Target COLLAGEN COLLAGEN ECM-Receptor 0.1981 0.00000807258936050593 Scatter Plot
Target SEMA4 Source NT NT Secreted Signaling 0.2013 0.0000057408188201817074 Scatter Plot
Target SEMA4 Source PTN PTN Secreted Signaling 0.2110 0.000001936241033625519 Scatter Plot
Target SEMA4 Source CD39 CD39 Cell-Cell Contact 0.2152 0.0000011881340086967386 Scatter Plot
Target SEMA4 Target VEGF VEGF Secreted Signaling 0.2164 0.0000010332481007194123 Scatter Plot
Target SEMA4 Source WNT WNT Secreted Signaling 0.2181 0.000000844255736541525 Scatter Plot
Target SEMA4 Source APELIN APELIN Secreted Signaling 0.2218 0.0000005473107949783166 Scatter Plot
Target SEMA4 Source CD1D2 CD1D2 Cell-Cell Contact 0.2272 0.0000002808244848288729 Scatter Plot
Target SEMA4 Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2316 0.00000016218746717408837 Scatter Plot
Target SEMA4 Target CSPG4 CSPG4 Cell-Cell Contact 0.2351 0.00000010488105845129719 Scatter Plot
Target SEMA4 Source ANGPTL ANGPTL Secreted Signaling 0.2383 0.00000006890534823436209 Scatter Plot
Target SEMA4 Source VEGF VEGF Secreted Signaling 0.2509 0.000000012877020933836066 Scatter Plot
Target SEMA4 Target CADM CADM Cell-Cell Contact 0.2547 0.000000007657100950788436 Scatter Plot
Target SEMA4 Source CADM CADM Cell-Cell Contact 0.2547 0.000000007657100950788436 Scatter Plot
Target SEMA4 Source IL2 IL2 Secreted Signaling 0.2559 0.00000000647755303393701 Scatter Plot
Target SEMA4 Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.2635 0.000000002177472300651774 Scatter Plot
Target SEMA4 Source IL16 IL16 Secreted Signaling 0.2644 0.0000000019035019273821103 Scatter Plot
Target SEMA4 Target SELPLG SELPLG Cell-Cell Contact 0.2646 0.000000001869797230417064 Scatter Plot
Target SEMA4 Target PTN PTN Secreted Signaling 0.2649 0.000000001784482970659439 Scatter Plot
Target SEMA4 Target GDF GDF Secreted Signaling 0.2667 0.0000000013657503075510118 Scatter Plot
Target SEMA4 Source CD46 CD46 Cell-Cell Contact 0.2684 0.0000000010668278484144183 Scatter Plot
Target SEMA4 Target SPP1 SPP1 Secreted Signaling 0.2701 0.0000000008254534737850765 Scatter Plot
Target SEMA4 Source FGF FGF Secreted Signaling 0.2708 0.0000000007519053633460681 Scatter Plot
Target SEMA4 Source NOTCH NOTCH Cell-Cell Contact 0.2858 0.00000000007404367124127278 Scatter Plot
Target SEMA4 Target MK MK Secreted Signaling 0.2861 0.00000000007080844792872939 Scatter Plot
Target SEMA4 Target ANGPTL ANGPTL Secreted Signaling 0.2867 0.00000000006510097862627904 Scatter Plot
Target SEMA4 Target SELL SELL Cell-Cell Contact 0.2890 0.00000000004495204893846295 Scatter Plot
Target SEMA4 Source RANKL RANKL Secreted Signaling 0.2890 0.000000000044697819886196116 Scatter Plot
Target SEMA4 Target SEMA7 SEMA7 Cell-Cell Contact 0.2898 0.0000000000390896940522958 Scatter Plot
Target SEMA4 Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.2971 0.00000000001188609457909464 Scatter Plot
Target SEMA4 Source GDF GDF Secreted Signaling 0.3034 0.000000000004144237951770372 Scatter Plot
Target SEMA4 Target NODAL NODAL Secreted Signaling 0.3059 0.0000000000026988005706554888 Scatter Plot
Target SEMA4 Target FN1 FN1 ECM-Receptor 0.3070 0.000000000002237999460390024 Scatter Plot
Target SEMA4 Source CCL CCL Secreted Signaling 0.3106 0.0000000000011965603201404325 Scatter Plot
Target SEMA4 Target THBS THBS ECM-Receptor 0.3110 0.0000000000011316342285397808 Scatter Plot
Target SEMA4 Source CX3C CX3C Secreted Signaling 0.3132 0.0000000000007655374066598376 Scatter Plot
Target SEMA4 Source VCAM VCAM Cell-Cell Contact 0.3164 0.00000000000043570294612709 Scatter Plot
Target SEMA4 Source IGF IGF Secreted Signaling 0.3208 0.00000000000019541334706859014 Scatter Plot
Target SEMA4 Source CSF CSF Secreted Signaling 0.3235 0.00000000000012093588282857293 Scatter Plot
Target SEMA4 Source EPHB EPHB Cell-Cell Contact 0.3314 0.0000000000000275412804246546 Scatter Plot
Target SEMA4 Source CD34 CD34 Cell-Cell Contact 0.3384 0.000000000000007246387935247654 Scatter Plot
Target SEMA4 Source CXCL CXCL Secreted Signaling 0.3423 0.0000000000000033945747906371608 Scatter Plot
Target SEMA4 Target VISFATIN VISFATIN Secreted Signaling 0.3461 0.000000000000001620024074668269 Scatter Plot
Source SEMA4 Source SPP1 SPP1 Secreted Signaling 0.3462 0.0000000000000015811941075029559 Scatter Plot
Target SEMA4 Source PROS PROS Secreted Signaling 0.3567 0.00000000000000018818037767452583 Scatter Plot
Target SEMA4 Source THY1 THY1 Cell-Cell Contact 0.3623 0.00000000000000005899953558136457 Scatter Plot
Target SEMA4 Source MK MK Secreted Signaling 0.3628 0.000000000000000053143620682678435 Scatter Plot
Target SEMA4 Target ACTIVIN ACTIVIN Secreted Signaling 0.3663 0.00000000000000002535903062927065 Scatter Plot
Target SEMA4 Target EPHB EPHB Cell-Cell Contact 0.3664 0.000000000000000024688760738479677 Scatter Plot
Target SEMA4 Source FLT3 FLT3 Secreted Signaling 0.3698 0.000000000000000011890718671899153 Scatter Plot
Target SEMA4 Target IGF IGF Secreted Signaling 0.3719 0.000000000000000007542051480824071 Scatter Plot
Target SEMA4 Source LIGHT LIGHT Secreted Signaling 0.3780 0.000000000000000001991481501067531 Scatter Plot
Target SEMA4 Source CD86 CD86 Cell-Cell Contact 0.3795 0.000000000000000001405433809173717 Scatter Plot
Target SEMA4 Target TGFb TGFb Secreted Signaling 0.3893 0.00000000000000000015401235409945444 Scatter Plot
Target SEMA4 Target NRG NRG Secreted Signaling 0.3942 0.0000000000000000000482639423168039 Scatter Plot
Source SEMA4 Source TGFb TGFb Secreted Signaling 0.3943 0.000000000000000000047945533426985505 Scatter Plot
Target SEMA4 Source LIFR LIFR Secreted Signaling 0.3950 0.00000000000000000004048382157837796 Scatter Plot
Target SEMA4 Target PERIOSTIN PERIOSTIN Secreted Signaling 0.3958 0.00000000000000000003371673311672075 Scatter Plot
Target SEMA4 Target LAMININ LAMININ ECM-Receptor 0.3959 0.000000000000000000032740723151546256 Scatter Plot
Target SEMA4 Target BSP BSP ECM-Receptor 0.3994 0.000000000000000000014131119329200788 Scatter Plot
Target SEMA4 Source PDGF PDGF Secreted Signaling 0.3996 0.00000000000000000001366532410029843 Scatter Plot
Target SEMA4 Target CD22 CD22 Cell-Cell Contact 0.4025 0.000000000000000000006672884236261836 Scatter Plot
Target SEMA4 Source CD45 CD45 Cell-Cell Contact 0.4025 0.000000000000000000006672884236261836 Scatter Plot
Target SEMA4 Source CDH CDH Cell-Cell Contact 0.4055 0.0000000000000000000032602965547934017 Scatter Plot
Target SEMA4 Target CDH CDH Cell-Cell Contact 0.4055 0.0000000000000000000032602965547934017 Scatter Plot
Target SEMA4 Target DMP1 DMP1 ECM-Receptor 0.4076 0.000000000000000000001945540476829836 Scatter Plot
Target SEMA4 Target ANGPT ANGPT Secreted Signaling 0.4101 0.0000000000000000000010542476148831129 Scatter Plot
Target SEMA4 Target VWF VWF ECM-Receptor 0.4142 0.0000000000000000000003774844603692414 Scatter Plot
Target SEMA4 Target BMP BMP Secreted Signaling 0.4148 0.00000000000000000000032516447442295226 Scatter Plot
Target SEMA4 Target VTN VTN ECM-Receptor 0.4191 0.0000000000000000000001074768747256712 Scatter Plot
Target SEMA4 Target NPR2 NPR2 Secreted Signaling 0.4214 0.00000000000000000000005948686199325114 Scatter Plot
Target SEMA4 Source IL7 IL7 Secreted Signaling 0.4264 0.000000000000000000000016371839675818444 Scatter Plot
Target SEMA4 Target CD200 CD200 Cell-Cell Contact 0.4308 0.0000000000000000000000051597617846010045 Scatter Plot
Target SEMA4 Source BMP BMP Secreted Signaling 0.4371 0.0000000000000000000000009410293013952346 Scatter Plot
Target SEMA4 Source LAMININ LAMININ ECM-Receptor 0.4397 0.0000000000000000000000004603208921577398 Scatter Plot
Target SEMA4 Source ICAM ICAM Cell-Cell Contact 0.4588 0.0000000000000000000000000020999499511629304 Scatter Plot
Target SEMA4 Target APP APP Cell-Cell Contact 0.4591 0.0000000000000000000000000019430898809954808 Scatter Plot
Source SEMA4 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.4614 0.0000000000000000000000000009837778749251443 Scatter Plot
Target SEMA4 Target JAM JAM Cell-Cell Contact 0.4621 0.0000000000000000000000000008008965136635057 Scatter Plot
Target SEMA4 Source SEMA7 SEMA7 Cell-Cell Contact 0.4625 0.000000000000000000000000000707842333439574 Scatter Plot
Target SEMA4 Target KIT KIT Secreted Signaling 0.4682 0.00000000000000000000000000012990082399481876 Scatter Plot
Source SEMA4 Source SELL SELL Cell-Cell Contact 0.4709 0.0000000000000000000000000000571015629513427 Scatter Plot
Target SEMA4 Source GAS GAS Secreted Signaling 0.4722 0.000000000000000000000000000039077619572827526 Scatter Plot
Target SEMA4 Source LCK LCK Cell-Cell Contact 0.4775 0.000000000000000000000000000007528009715018697 Scatter Plot
Target SEMA4 Target FGF FGF Secreted Signaling 0.4791 0.000000000000000000000000000004644102734356167 Scatter Plot
Target SEMA4 Source TWEAK TWEAK Secreted Signaling 0.4809 0.0000000000000000000000000000026553466920976613 Scatter Plot
Target SEMA4 Target TENASCIN TENASCIN ECM-Receptor 0.4823 0.0000000000000000000000000000016910244173674762 Scatter Plot
Target SEMA4 Source PSAP PSAP Secreted Signaling 0.4860 0.0000000000000000000000000000005301811206918456 Scatter Plot
Target SEMA4 Target SLURP SLURP Secreted Signaling 0.4867 0.00000000000000000000000000000041899723673380436 Scatter Plot
Target SEMA4 Source BST2 BST2 Cell-Cell Contact 0.5131 0.00000000000000000000000000000000006108318053857378 Scatter Plot
Target SEMA4 Source COLLAGEN COLLAGEN ECM-Receptor 0.5151 0.000000000000000000000000000000000031104523405386893 Scatter Plot
Target SEMA4 Source ESAM ESAM Cell-Cell Contact 0.5217 0.0000000000000000000000000000000000029229008103513973 Scatter Plot
Target SEMA4 Target ESAM ESAM Cell-Cell Contact 0.5217 0.0000000000000000000000000000000000029229008103513973 Scatter Plot
Target SEMA4 Target WNT WNT Secreted Signaling 0.5252 0.0000000000000000000000000000000000008228224729271386 Scatter Plot
Target SEMA4 Target ncWNT ncWNT Secreted Signaling 0.5312 0.00000000000000000000000000000000000009058311133890112 Scatter Plot
Target SEMA4 Target MIF MIF Secreted Signaling 0.5391 0.000000000000000000000000000000000000004785330017575684 Scatter Plot
Target SEMA4 Target CD34 CD34 Cell-Cell Contact 0.5456 0.00000000000000000000000000000000000000039554856356789155 Scatter Plot
Target SEMA4 Source JAM JAM Cell-Cell Contact 0.5565 0.0000000000000000000000000000000000000000052137074900892973 Scatter Plot
Target SEMA4 Source MHC-I MHC-I Cell-Cell Contact 0.5784 0.0000000000000000000000000000000000000000000005435796189376732 Scatter Plot
Target SEMA4 Target CD39 CD39 Cell-Cell Contact 0.5800 0.00000000000000000000000000000000000000000000026582386351460792 Scatter Plot
Target SEMA4 Source ANGPT ANGPT Secreted Signaling 0.5836 0.00000000000000000000000000000000000000000000005494008425082977 Scatter Plot
Target SEMA4 Source MHC-II MHC-II Cell-Cell Contact 0.6612 0.00000000000000000000000000000000000000000000000000000000000000034721309494030536 Scatter Plot
Source SEMA4 Source ANGPT ANGPT Secreted Signaling -0.5086 0.0000000000000000000000000000000002886213944678698 Scatter Plot
Target SEMA4 Source COMPLEMENT COMPLEMENT Secreted Signaling -0.4283 0.000000000000000000000009848305497983112 Scatter Plot
Target SEMA4 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.3656 0.000000000000000029143140141467134 Scatter Plot
Source SEMA4 Source LIFR LIFR Secreted Signaling -0.3590 0.00000000000000011758129539073404 Scatter Plot
Target SEMA4 Source VISTA VISTA Cell-Cell Contact -0.3158 0.0000000000004805974983784333 Scatter Plot
Target SEMA4 Source CD52 CD52 Cell-Cell Contact -0.3128 0.0000000000008278765961696761 Scatter Plot
Target SEMA4 Source PARs PARs Secreted Signaling -0.2742 0.00000000044738361642538335 Scatter Plot
Target SEMA4 Target CSF CSF Secreted Signaling -0.2708 0.0000000007502558724169449 Scatter Plot
Target SEMA4 Target CEACAM CEACAM Cell-Cell Contact -0.2668 0.0000000013539623889197011 Scatter Plot
Source SEMA4 Source ESAM ESAM Cell-Cell Contact -0.2557 0.000000006642790406971659 Scatter Plot
Source SEMA4 Source GRN GRN Secreted Signaling -0.2432 0.000000036548943508911824 Scatter Plot
Source SEMA4 Source PROS PROS Secreted Signaling -0.2399 0.00000005585853913230993 Scatter Plot
Source SEMA4 Source VISTA VISTA Cell-Cell Contact -0.2279 0.0000002597427569632764 Scatter Plot
Target SEMA4 Source BAFF BAFF Secreted Signaling -0.2261 0.0000003239751460216444 Scatter Plot
Target SEMA4 Source SELL SELL Cell-Cell Contact -0.2246 0.0000003875588187470095 Scatter Plot
Target SEMA4 Source NCAM NCAM Cell-Cell Contact -0.2170 0.000000969690464717283 Scatter Plot
Target SEMA4 Source APP APP Cell-Cell Contact -0.2145 0.0000012994693133196982 Scatter Plot
Source SEMA4 Source CD39 CD39 Cell-Cell Contact -0.2127 0.0000015985215002494945 Scatter Plot
Source SEMA4 Source LAMININ LAMININ ECM-Receptor -0.2118 0.000001757858704712724 Scatter Plot
Source SEMA4 Source CDH CDH Cell-Cell Contact -0.2047 0.000003917204227917826 Scatter Plot
Target SEMA4 Target CXCL CXCL Secreted Signaling -0.2006 0.000006198374978890024 Scatter Plot
Target SEMA4 Source SPP1 SPP1 Secreted Signaling -0.2002 0.000006425200066965139 Scatter Plot
Source SEMA4 Source FGF FGF Secreted Signaling -0.1975 0.000008587553782053447 Scatter Plot
Source SEMA4 Source TWEAK TWEAK Secreted Signaling -0.1936 0.000013026905601954378 Scatter Plot
Target SEMA4 Source CLEC CLEC Cell-Cell Contact -0.1932 0.000013580774562706116 Scatter Plot
Target SEMA4 Target ANNEXIN ANNEXIN Secreted Signaling -0.1892 0.000020467997112623072 Scatter Plot
Source SEMA4 Source VEGF VEGF Secreted Signaling -0.1871 0.000025395370385406725 Scatter Plot
Target SEMA4 Source ANNEXIN ANNEXIN Secreted Signaling -0.1780 0.00006271731507490908 Scatter Plot
Source SEMA4 Source SEMA3 SEMA3 Secreted Signaling -0.1655 0.0002014400613542 Scatter Plot
Target SEMA4 Target IL17 IL17 Secreted Signaling -0.1646 0.0002177044508946 Scatter Plot
Source SEMA4 Source ncWNT ncWNT Secreted Signaling -0.1624 0.0002650924473962 Scatter Plot
Target SEMA4 Source TNF TNF Secreted Signaling -0.1611 0.0002972573777256 Scatter Plot
Source SEMA4 Source NCAM NCAM Cell-Cell Contact -0.1605 0.000314642724884 Scatter Plot
Source SEMA4 Source PTN PTN Secreted Signaling -0.1591 0.0003555470605555 Scatter Plot
Target SEMA4 Target VEGF VEGF Secreted Signaling -0.1501 0.0007609249720876 Scatter Plot
Source SEMA4 Source CD34 CD34 Cell-Cell Contact -0.1466 0.0010123799183301 Scatter Plot
Source SEMA4 Source SEMA7 SEMA7 Cell-Cell Contact -0.1424 0.0014056058704714 Scatter Plot
Target SEMA4 Source TGFb TGFb Secreted Signaling -0.1333 0.0028257236656585 Scatter Plot
Source SEMA4 Source APELIN APELIN Secreted Signaling -0.1294 0.0037463724185019 Scatter Plot
Target SEMA4 Source MIF MIF Secreted Signaling -0.1226 0.0060358000233066 Scatter Plot
Target SEMA4 Source ANGPTL ANGPTL Secreted Signaling -0.1181 0.0082278540593246 Scatter Plot
Source SEMA4 Source AGRN AGRN ECM-Receptor -0.1149 0.0101123530568799 Scatter Plot
Source SEMA4 Source OSM OSM Secreted Signaling -0.1118 0.0123671837379637 Scatter Plot
Target SEMA4 Source IL1 IL1 Secreted Signaling -0.1117 0.0124598509024869 Scatter Plot
Source SEMA4 Source THBS THBS ECM-Receptor -0.1033 0.0209078899706918 Scatter Plot
Target SEMA4 Source LAIR1 LAIR1 Cell-Cell Contact -0.0969 0.0302894267020578 Scatter Plot
Source SEMA4 Target CD45 CD45 Cell-Cell Contact 0.0996 0.0259852921310431 Scatter Plot
Source SEMA4 Target PARs PARs Secreted Signaling 0.1012 0.0236965725810746 Scatter Plot
Source SEMA4 Target TWEAK TWEAK Secreted Signaling 0.1161 0.0093855058042841 Scatter Plot
Source SEMA4 Target SEMA7 SEMA7 Cell-Cell Contact 0.1206 0.0069367950419995 Scatter Plot
Source SEMA4 Target CD86 CD86 Cell-Cell Contact 0.1217 0.0064332807261242 Scatter Plot
Source SEMA4 Target GALECTIN GALECTIN Secreted Signaling 0.1240 0.0054810819798645 Scatter Plot
Source SEMA4 Source NKG2D NKG2D Cell-Cell Contact 0.1250 0.0051203648347696 Scatter Plot
Target SEMA4 Target THY1 THY1 Cell-Cell Contact 0.1297 0.0036700986121046 Scatter Plot
Source SEMA4 Source SEMA6 SEMA6 Cell-Cell Contact 0.1328 0.0029228918551414 Scatter Plot
Target SEMA4 Target CD86 CD86 Cell-Cell Contact 0.1382 0.0019541060543429 Scatter Plot
Source SEMA4 Target GRN GRN Secreted Signaling 0.1454 0.0011111141585149 Scatter Plot
Source SEMA4 Target ANGPTL ANGPTL Secreted Signaling 0.1456 0.0010981484147862 Scatter Plot
Source SEMA4 Target PTN PTN Secreted Signaling 0.1457 0.0010830163798637 Scatter Plot
Source SEMA4 Target SPP1 SPP1 Secreted Signaling 0.1468 0.0009927012919135 Scatter Plot
Source SEMA4 Target SELL SELL Cell-Cell Contact 0.1522 0.0006361017435502 Scatter Plot
Source SEMA4 Target FN1 FN1 ECM-Receptor 0.1571 0.0004226067140669 Scatter Plot
Source SEMA4 Target SELE SELE Cell-Cell Contact 0.1576 0.0004048348683439 Scatter Plot
Source SEMA4 Source SELPLG SELPLG Cell-Cell Contact 0.1595 0.0003419398611304 Scatter Plot
Source SEMA4 Target IL17 IL17 Secreted Signaling 0.1602 0.0003214630937088 Scatter Plot
Source SEMA4 Source CCL CCL Secreted Signaling 0.1649 0.000213063714299 Scatter Plot
Source SEMA4 Target NCAM NCAM Cell-Cell Contact 0.1673 0.0001719037231709 Scatter Plot
Source SEMA4 Target MK MK Secreted Signaling 0.1706 0.0001262529094035 Scatter Plot
Target SEMA4 Target EPHA EPHA Cell-Cell Contact 0.1714 0.0001168210745872 Scatter Plot
Source SEMA4 Target IL1 IL1 Secreted Signaling 0.1750 0.00008363630853661722 Scatter Plot
Source SEMA4 Target COLLAGEN COLLAGEN ECM-Receptor 0.1777 0.00006440724947141299 Scatter Plot
Source SEMA4 Source IL1 IL1 Secreted Signaling 0.1828 0.00003927815368075759 Scatter Plot
Source SEMA4 Target PDGF PDGF Secreted Signaling 0.1833 0.00003717602652975217 Scatter Plot
Target SEMA4 Target OSM OSM Secreted Signaling 0.1910 0.000017125154351800404 Scatter Plot
Source SEMA4 Target SELPLG SELPLG Cell-Cell Contact 0.1939 0.000012676330505515771 Scatter Plot
Source SEMA4 Source MIF MIF Secreted Signaling 0.2128 0.0000015658849281540023 Scatter Plot
Source SEMA4 Source ANGPTL ANGPTL Secreted Signaling 0.2143 0.000001325851734293304 Scatter Plot
Source SEMA4 Target SEMA3 SEMA3 Secreted Signaling 0.2146 0.000001276456311093445 Scatter Plot
Source SEMA4 Target CD23 CD23 Cell-Cell Contact 0.2399 0.0000000565359482106653 Scatter Plot
Target SEMA4 Target SELPLG SELPLG Cell-Cell Contact 0.2584 0.0000000045097606464674575 Scatter Plot
Source SEMA4 Source BAFF BAFF Secreted Signaling 0.2607 0.0000000032735592175469875 Scatter Plot
Source SEMA4 Source GRN GRN Secreted Signaling 0.2621 0.000000002676839224520388 Scatter Plot
Source SEMA4 Target THY1 THY1 Cell-Cell Contact 0.2649 0.000000001786524594477802 Scatter Plot
Source SEMA4 Target VEGF VEGF Secreted Signaling 0.2659 0.0000000015463650466083248 Scatter Plot
Source SEMA4 Target ANNEXIN ANNEXIN Secreted Signaling 0.2754 0.00000000037524999734411317 Scatter Plot
Source SEMA4 Source LAIR1 LAIR1 Cell-Cell Contact 0.2797 0.00000000019267795612847726 Scatter Plot
Target SEMA4 Target IL6 IL6 Secreted Signaling 0.2804 0.000000000172592847512262 Scatter Plot
Source SEMA4 Source TNF TNF Secreted Signaling 0.2877 0.00000000005475258045013191 Scatter Plot
Source SEMA4 Source CLEC CLEC Cell-Cell Contact 0.2987 0.000000000009141530272513544 Scatter Plot
Source SEMA4 Target CXCL CXCL Secreted Signaling 0.3086 0.0000000000017076230979666028 Scatter Plot
Source SEMA4 Target CSF CSF Secreted Signaling 0.3123 0.0000000000008967616567874266 Scatter Plot
Target SEMA4 Target SEMA7 SEMA7 Cell-Cell Contact 0.3140 0.0000000000006668556207150454 Scatter Plot
Target SEMA4 Target SPP1 SPP1 Secreted Signaling 0.3186 0.0000000000002935394941807473 Scatter Plot
Source SEMA4 Target COMPLEMENT COMPLEMENT Secreted Signaling 0.3359 0.000000000000011787118070216112 Scatter Plot
Source SEMA4 Source NCAM NCAM Cell-Cell Contact 0.3478 0.000000000000001149303888026047 Scatter Plot
Source SEMA4 Source GALECTIN GALECTIN Secreted Signaling 0.3493 0.0000000000000008523694492676855 Scatter Plot
Source SEMA4 Source SPP1 SPP1 Secreted Signaling 0.3654 0.00000000000000003027994417109643 Scatter Plot
Source SEMA4 Target CCL CCL Secreted Signaling 0.3781 0.0000000000000000019284425544692298 Scatter Plot
Target SEMA4 Target PARs PARs Secreted Signaling 0.3945 0.00000000000000000004482747454515925 Scatter Plot
Source SEMA4 Target IFN-II IFN-II Secreted Signaling 0.3980 0.00000000000000000001996373034661828 Scatter Plot
Target SEMA4 Target SELL SELL Cell-Cell Contact 0.4007 0.000000000000000000010478395335283112 Scatter Plot
Source SEMA4 Target CLEC CLEC Cell-Cell Contact 0.4080 0.000000000000000000001770123999724034 Scatter Plot
Source SEMA4 Source PARs PARs Secreted Signaling 0.4093 0.0000000000000000000012869198998753548 Scatter Plot
Source SEMA4 Source APP APP Cell-Cell Contact 0.4146 0.0000000000000000000003403068547824758 Scatter Plot
Source SEMA4 Target CEACAM CEACAM Cell-Cell Contact 0.4268 0.00000000000000000000001488723981094948 Scatter Plot
Source SEMA4 Source ANNEXIN ANNEXIN Secreted Signaling 0.4309 0.000000000000000000000005004907244881036 Scatter Plot
Source SEMA4 Target VCAM VCAM Cell-Cell Contact 0.4465 0.00000000000000000000000007078631855452625 Scatter Plot
Source SEMA4 Target CD52 CD52 Cell-Cell Contact 0.4478 0.00000000000000000000000004905824427686694 Scatter Plot
Source SEMA4 Source SELL SELL Cell-Cell Contact 0.4709 0.0000000000000000000000000000571015629513427 Scatter Plot
Source SEMA4 Source VISTA VISTA Cell-Cell Contact 0.4762 0.000000000000000000000000000011454180287783497 Scatter Plot
Target SEMA4 Target BAFF BAFF Secreted Signaling 0.4928 0.00000000000000000000000000000005922846829929134 Scatter Plot
Source SEMA4 Target ICAM ICAM Cell-Cell Contact 0.5136 0.00000000000000000000000000000000005216226674781004 Scatter Plot
Source SEMA4 Source CD52 CD52 Cell-Cell Contact 0.5499 0.0000000000000000000000000000000000000000712468264336711 Scatter Plot
Source SEMA4 Source COMPLEMENT COMPLEMENT Secreted Signaling 0.5775 0.000000000000000000000000000000000000000000000782544523247482 Scatter Plot
Source SEMA4 Target PARs PARs Secreted Signaling -0.4885 0.0000000000000000000000000000002353904230930228 Scatter Plot
Source SEMA4 Target KIT KIT Secreted Signaling -0.4869 0.0000000000000000000000000000003956495220628417 Scatter Plot
Source SEMA4 Source MHC-II MHC-II Cell-Cell Contact -0.4711 0.00000000000000000000000000005492131627271064 Scatter Plot
Source SEMA4 Target MK MK Secreted Signaling -0.4655 0.00000000000000000000000000029159935821447677 Scatter Plot
Source SEMA4 Target CD34 CD34 Cell-Cell Contact -0.4605 0.0000000000000000000000000012746265801367956 Scatter Plot
Source SEMA4 Source GALECTIN GALECTIN Secreted Signaling -0.4597 0.000000000000000000000000001610820053415682 Scatter Plot
Source SEMA4 Target ncWNT ncWNT Secreted Signaling -0.4367 0.000000000000000000000001050339933757313 Scatter Plot
Source SEMA4 Target TENASCIN TENASCIN ECM-Receptor -0.4311 0.0000000000000000000000048054355609902815 Scatter Plot
Source SEMA4 Target WNT WNT Secreted Signaling -0.4288 0.00000000000000000000000873003990790751 Scatter Plot
Source SEMA4 Target PTN PTN Secreted Signaling -0.4118 0.0000000000000000000006821174844379244 Scatter Plot
Source SEMA4 Source EPHB EPHB Cell-Cell Contact -0.3971 0.000000000000000000024621980682149934 Scatter Plot
Source SEMA4 Source FLT3 FLT3 Secreted Signaling -0.3776 0.0000000000000000021693322812598003 Scatter Plot
Source SEMA4 Source LCK LCK Cell-Cell Contact -0.3630 0.00000000000000005051962818196504 Scatter Plot
Target SEMA4 Target VCAM VCAM Cell-Cell Contact -0.3630 0.000000000000000050797200085877684 Scatter Plot
Source SEMA4 Target VWF VWF ECM-Receptor -0.3563 0.00000000000000020342571102229127 Scatter Plot
Source SEMA4 Source VCAM VCAM Cell-Cell Contact -0.3481 0.0000000000000010769317322524436 Scatter Plot
Source SEMA4 Target TGFb TGFb Secreted Signaling -0.3427 0.000000000000003133435097443461 Scatter Plot
Target SEMA4 Target ICAM ICAM Cell-Cell Contact -0.3293 0.00000000000004092988185117336 Scatter Plot
Source SEMA4 Target NCAM NCAM Cell-Cell Contact -0.3191 0.00000000000026838634236890306 Scatter Plot
Source SEMA4 Target ANGPT ANGPT Secreted Signaling -0.3147 0.0000000000005890503458656072 Scatter Plot
Source SEMA4 Target SEMA7 SEMA7 Cell-Cell Contact -0.3105 0.0000000000012217907889650132 Scatter Plot
Source SEMA4 Target VTN VTN ECM-Receptor -0.3084 0.000000000001759791447118612 Scatter Plot
Source SEMA4 Target SPP1 SPP1 Secreted Signaling -0.3041 0.000000000003723068223751697 Scatter Plot
Source SEMA4 Target LAMININ LAMININ ECM-Receptor -0.2999 0.000000000007474538264461053 Scatter Plot
Source SEMA4 Source ANNEXIN ANNEXIN Secreted Signaling -0.2966 0.000000000012898932937311335 Scatter Plot
Source SEMA4 Target SEMA5 SEMA5 Cell-Cell Contact -0.2911 0.000000000031827634763865746 Scatter Plot
Source SEMA4 Target JAM JAM Cell-Cell Contact -0.2830 0.00000000011602970477850461 Scatter Plot
Source SEMA4 Target FGF FGF Secreted Signaling -0.2797 0.00000000019369033340114818 Scatter Plot
Source SEMA4 Target ACTIVIN ACTIVIN Secreted Signaling -0.2785 0.00000000023299897836414516 Scatter Plot
Source SEMA4 Target FN1 FN1 ECM-Receptor -0.2748 0.00000000041169893505970124 Scatter Plot
Source SEMA4 Target EPHB EPHB Cell-Cell Contact -0.2696 0.0000000008884751083053356 Scatter Plot
Source SEMA4 Source APP APP Cell-Cell Contact -0.2683 0.0000000010820933387653884 Scatter Plot
Source SEMA4 Source ICAM ICAM Cell-Cell Contact -0.2662 0.0000000014737030990590299 Scatter Plot
Source SEMA4 Source IGF IGF Secreted Signaling -0.2649 0.000000001791018158760795 Scatter Plot
Source SEMA4 Source SEMA7 SEMA7 Cell-Cell Contact -0.2643 0.00000000194233635062336 Scatter Plot
Source SEMA4 Source MK MK Secreted Signaling -0.2628 0.000000002432431045898389 Scatter Plot
Source SEMA4 Target CD23 CD23 Cell-Cell Contact -0.2596 0.0000000038145294841242785 Scatter Plot
Source SEMA4 Source MHC-I MHC-I Cell-Cell Contact -0.2592 0.000000004061060028795464 Scatter Plot
Source SEMA4 Target CD200 CD200 Cell-Cell Contact -0.2579 0.0000000048592936423935804 Scatter Plot
Source SEMA4 Target ESAM ESAM Cell-Cell Contact -0.2557 0.000000006642790406971659 Scatter Plot
Source SEMA4 Source JAM JAM Cell-Cell Contact -0.2550 0.000000007285778798624198 Scatter Plot
Target SEMA4 Target IFN-II IFN-II Secreted Signaling -0.2535 0.000000008979193942943797 Scatter Plot
Source SEMA4 Target THY1 THY1 Cell-Cell Contact -0.2524 0.000000010503403548762703 Scatter Plot
Source SEMA4 Source GP1BA GP1BA Cell-Cell Contact -0.2474 0.000000020649415079507957 Scatter Plot
Source SEMA4 Target SEMA6 SEMA6 Cell-Cell Contact -0.2469 0.000000022115821231928103 Scatter Plot
Target SEMA4 Target CD52 CD52 Cell-Cell Contact -0.2447 0.000000029756357631771948 Scatter Plot
Source SEMA4 Target VISFATIN VISFATIN Secreted Signaling -0.2441 0.000000032097764041209355 Scatter Plot
Source SEMA4 Source GAS GAS Secreted Signaling -0.2408 0.000000049925827907135435 Scatter Plot
Source SEMA4 Source BMP BMP Secreted Signaling -0.2358 0.0000000957419258177568 Scatter Plot
Source SEMA4 Target THBS THBS ECM-Receptor -0.2344 0.0000001136097576276427 Scatter Plot
Target SEMA4 Target CCL CCL Secreted Signaling -0.2333 0.00000013068683400183893 Scatter Plot
Target SEMA4 Target CLEC CLEC Cell-Cell Contact -0.2315 0.00000016435549229013745 Scatter Plot
Source SEMA4 Source COLLAGEN COLLAGEN ECM-Receptor -0.2296 0.00000021036794033435185 Scatter Plot
Source SEMA4 Source IL16 IL16 Secreted Signaling -0.2232 0.0000004621728726242912 Scatter Plot
Source SEMA4 Source CXCL CXCL Secreted Signaling -0.2219 0.0000005378400248081358 Scatter Plot
Source SEMA4 Target CD22 CD22 Cell-Cell Contact -0.2162 0.0000010602459106241404 Scatter Plot
Source SEMA4 Source CD45 CD45 Cell-Cell Contact -0.2162 0.00000106024591062415 Scatter Plot
Source SEMA4 Source BST2 BST2 Cell-Cell Contact -0.2151 0.0000012026559318083217 Scatter Plot
Source SEMA4 Target APP APP Cell-Cell Contact -0.2147 0.000001267674264048973 Scatter Plot
Source SEMA4 Source CD46 CD46 Cell-Cell Contact -0.2103 0.0000020962230491029675 Scatter Plot
Source SEMA4 Target CD39 CD39 Cell-Cell Contact -0.2056 0.0000035745057147813845 Scatter Plot
Source SEMA4 Target CDH CDH Cell-Cell Contact -0.2047 0.000003917204227917826 Scatter Plot
Source SEMA4 Target ANGPTL ANGPTL Secreted Signaling -0.2040 0.0000042627439601623644 Scatter Plot
Source SEMA4 Source NT NT Secreted Signaling -0.2026 0.000004959537675562053 Scatter Plot
Source SEMA4 Target MIF MIF Secreted Signaling -0.2008 0.000006063733276121013 Scatter Plot
Source SEMA4 Source PDGF PDGF Secreted Signaling -0.1968 0.000009311829975196622 Scatter Plot
Source SEMA4 Target ADIPONECTIN ADIPONECTIN Secreted Signaling -0.1941 0.000012384173140544625 Scatter Plot
Source SEMA4 Target IGF IGF Secreted Signaling -0.1931 0.000013750313099696867 Scatter Plot
Source SEMA4 Source CX3C CX3C Secreted Signaling -0.1929 0.000014018671850387056 Scatter Plot
Source SEMA4 Source CD1D2 CD1D2 Cell-Cell Contact -0.1894 0.00002017439821938768 Scatter Plot
Source SEMA4 Target SLURP SLURP Secreted Signaling -0.1889 0.000021295266187828373 Scatter Plot
Source SEMA4 Target AGT AGT Secreted Signaling -0.1851 0.000031071317501314825 Scatter Plot
Source SEMA4 Source LIGHT LIGHT Secreted Signaling -0.1842 0.00003410685468524584 Scatter Plot
Source SEMA4 Source THY1 THY1 Cell-Cell Contact -0.1832 0.00003782998878790958 Scatter Plot
Source SEMA4 Target OSM OSM Secreted Signaling -0.1810 0.00004692398528387954 Scatter Plot
Source SEMA4 Target COMPLEMENT COMPLEMENT Secreted Signaling -0.1775 0.0000661415601606142 Scatter Plot
Source SEMA4 Target DMP1 DMP1 ECM-Receptor -0.1769 0.0000694700268271297 Scatter Plot
Source SEMA4 Source CCL CCL Secreted Signaling -0.1762 0.00007422976397806837 Scatter Plot
Source SEMA4 Source IL7 IL7 Secreted Signaling -0.1762 0.00007481890053324434 Scatter Plot
Source SEMA4 Target GALECTIN GALECTIN Secreted Signaling -0.1760 0.00007600913111637596 Scatter Plot
Source SEMA4 Target NPR2 NPR2 Secreted Signaling -0.1743 0.00008905277772252675 Scatter Plot
Source SEMA4 Source CSF CSF Secreted Signaling -0.1737 0.00009437328955671845 Scatter Plot
Source SEMA4 Target PDGF PDGF Secreted Signaling -0.1734 0.00009685087349171564 Scatter Plot
Source SEMA4 Source LAIR1 LAIR1 Cell-Cell Contact -0.1729 0.0001016944638398 Scatter Plot
Source SEMA4 Source IL2 IL2 Secreted Signaling -0.1722 0.0001086830725082 Scatter Plot
Source SEMA4 Source GDF GDF Secreted Signaling -0.1718 0.0001134029690511 Scatter Plot
Source SEMA4 Target CSPG4 CSPG4 Cell-Cell Contact -0.1710 0.0001215725580149 Scatter Plot
Source SEMA4 Source CADM CADM Cell-Cell Contact -0.1706 0.0001268062771219 Scatter Plot
Source SEMA4 Target CADM CADM Cell-Cell Contact -0.1706 0.0001268062771219 Scatter Plot
Source SEMA4 Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.1697 0.0001370814065091 Scatter Plot
Source SEMA4 Target BAFF BAFF Secreted Signaling -0.1693 0.0001428726032445 Scatter Plot
Source SEMA4 Target BMP BMP Secreted Signaling -0.1679 0.0001615385356289 Scatter Plot
Source SEMA4 Target NRG NRG Secreted Signaling -0.1676 0.0001661821843055 Scatter Plot
Source SEMA4 Source PSAP PSAP Secreted Signaling -0.1631 0.0002505305882787 Scatter Plot
Source SEMA4 Target BSP BSP ECM-Receptor -0.1629 0.000253347176472 Scatter Plot
Source SEMA4 Target SELL SELL Cell-Cell Contact -0.1627 0.0002582258654272 Scatter Plot
Source SEMA4 Target CEACAM CEACAM Cell-Cell Contact -0.1610 0.0003010335047333 Scatter Plot
Source SEMA4 Target NOTCH NOTCH Cell-Cell Contact -0.1604 0.0003157912751871 Scatter Plot
Source SEMA4 Source RANKL RANKL Secreted Signaling -0.1598 0.0003341504683158 Scatter Plot
Source SEMA4 Source CD86 CD86 Cell-Cell Contact -0.1587 0.0003681032678983 Scatter Plot
Source SEMA4 Source COMPLEMENT COMPLEMENT Secreted Signaling -0.1553 0.0004918544024093 Scatter Plot
Source SEMA4 Target COLLAGEN COLLAGEN ECM-Receptor -0.1538 0.0005593789912356 Scatter Plot
Source SEMA4 Target IL6 IL6 Secreted Signaling -0.1526 0.0006151893771415 Scatter Plot
Source SEMA4 Target PERIOSTIN PERIOSTIN Secreted Signaling -0.1504 0.0007381680349629 Scatter Plot
Source SEMA4 Target EPHA EPHA Cell-Cell Contact -0.1454 0.0011106862277202 Scatter Plot
Source SEMA4 Target IL1 IL1 Secreted Signaling -0.1426 0.0013924045790263 Scatter Plot
Source SEMA4 Source ANGPTL ANGPTL Secreted Signaling -0.1409 0.0015813626292091 Scatter Plot
Source SEMA4 Target VCAM VCAM Cell-Cell Contact -0.1355 0.0023894790348774 Scatter Plot
Source SEMA4 Target GDF GDF Secreted Signaling -0.1342 0.0026302630648254 Scatter Plot
Target SEMA4 Target COLLAGEN COLLAGEN ECM-Receptor -0.1339 0.0026941311074825 Scatter Plot
Source SEMA4 Source NOTCH NOTCH Cell-Cell Contact -0.1314 0.0032548481587782 Scatter Plot
Source SEMA4 Target NODAL NODAL Secreted Signaling -0.1305 0.0034680732307184 Scatter Plot
Target SEMA4 Target COMPLEMENT COMPLEMENT Secreted Signaling -0.1290 0.0038682189141382 Scatter Plot
Source SEMA4 Target VEGF VEGF Secreted Signaling -0.1240 0.0054981700202548 Scatter Plot
Target SEMA4 Target GRN GRN Secreted Signaling -0.1182 0.0081333999337076 Scatter Plot
Source SEMA4 Target GAS GAS Secreted Signaling -0.1144 0.0104637511325073 Scatter Plot
Source SEMA4 Target RANKL RANKL Secreted Signaling -0.1131 0.0114086019655635 Scatter Plot
Source SEMA4 Target TWEAK TWEAK Secreted Signaling -0.1078 0.0158480231434494 Scatter Plot
Source SEMA4 Target ANNEXIN ANNEXIN Secreted Signaling -0.1041 0.0199251797585447 Scatter Plot
Source SEMA4 Target BST2 BST2 Cell-Cell Contact -0.0970 0.030066772004552 Scatter Plot
Source SEMA4 Target LAIR1 LAIR1 Cell-Cell Contact -0.0970 0.030066772004552 Scatter Plot
Source SEMA4 Source SEMA3 SEMA3 Secreted Signaling -0.0967 0.030618045569409 Scatter Plot

Cells that are targets of SEMA4 from HSCs*

Cells that are source of SEMA4 to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.