Pathway: CD46

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Cell-Cell Contact

Details on the CD46 pathway:

Specificity Index HSPC as target: 0.082
HSPC as source: 0.552

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the CD46 pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Source CD46 Source AGRN AGRN ECM-Receptor 0.1097 0.0141043186995996 Scatter Plot
Source CD46 Source CD39 CD39 Cell-Cell Contact 0.1184 0.0080587183213223 Scatter Plot
Source CD46 Source VEGF VEGF Secreted Signaling 0.1659 0.0001941732063901 Scatter Plot
Source CD46 Source APELIN APELIN Secreted Signaling 0.1680 0.0001603295727376 Scatter Plot
Source CD46 Source CCL CCL Secreted Signaling 0.1903 0.00001838157353839633 Scatter Plot
Source CD46 Source SEMA3 SEMA3 Secreted Signaling 0.2010 0.000005882823809871264 Scatter Plot
Source CD46 Source CD45 CD45 Cell-Cell Contact 0.2023 0.000005114683366112337 Scatter Plot
Source CD46 Source SEMA6 SEMA6 Cell-Cell Contact 0.2090 0.000002441678776736354 Scatter Plot
Source CD46 Source LIGHT LIGHT Secreted Signaling 0.2123 0.0000016647836875205485 Scatter Plot
Source CD46 Source EPHB EPHB Cell-Cell Contact 0.2310 0.0000001760037774428173 Scatter Plot
Source CD46 Source CDH CDH Cell-Cell Contact 0.2322 0.00000015192676548703969 Scatter Plot
Source CD46 Source PROS PROS Secreted Signaling 0.2332 0.00000013389962468690276 Scatter Plot
Source CD46 Source PDGF PDGF Secreted Signaling 0.2350 0.00000010580869420768892 Scatter Plot
Source CD46 Source NT NT Secreted Signaling 0.2356 0.00000009806852843361373 Scatter Plot
Source CD46 Source LIFR LIFR Secreted Signaling 0.2488 0.00000001711891311073937 Scatter Plot
Source CD46 Source PSAP PSAP Secreted Signaling 0.2521 0.000000010948679846672313 Scatter Plot
Source CD46 Source LAMININ LAMININ ECM-Receptor 0.2656 0.0000000016171277092887102 Scatter Plot
Source CD46 Source CADM CADM Cell-Cell Contact 0.2919 0.00000000002807099355457313 Scatter Plot
Source CD46 Source RANKL RANKL Secreted Signaling 0.3026 0.000000000004757184099888146 Scatter Plot
Source CD46 Source ANGPT ANGPT Secreted Signaling 0.3067 0.0000000000023783481299843133 Scatter Plot
Source CD46 Source TWEAK TWEAK Secreted Signaling 0.3106 0.0000000000011962047502430366 Scatter Plot
Source CD46 Source COLLAGEN COLLAGEN ECM-Receptor 0.3304 0.000000000000033381775807635543 Scatter Plot
Source CD46 Source GAS GAS Secreted Signaling 0.3436 0.000000000000002647313375506105 Scatter Plot
Source CD46 Source BMP BMP Secreted Signaling 0.3583 0.0000000000000001357204839633912 Scatter Plot
Source CD46 Source SELL SELL Cell-Cell Contact -0.2426 0.000000039573448878430596 Scatter Plot
Source CD46 Source PARs PARs Secreted Signaling -0.2409 0.00000004946944265175357 Scatter Plot
Source CD46 Source SEMA4 SEMA4 Cell-Cell Contact -0.2103 0.0000020962230491029675 Scatter Plot
Source CD46 Source TGFb TGFb Secreted Signaling -0.2049 0.000003827488604450573 Scatter Plot
Source CD46 Source VISFATIN VISFATIN Secreted Signaling -0.1536 0.0005674044394135 Scatter Plot
Source CD46 Source ANGPTL ANGPTL Secreted Signaling -0.1342 0.0026464016924801 Scatter Plot
Source CD46 Source NCAM NCAM Cell-Cell Contact -0.1263 0.0046908852423344 Scatter Plot
Source CD46 Source TNF TNF Secreted Signaling -0.1253 0.005033911233621 Scatter Plot
Source CD46 Target COMPLEMENT COMPLEMENT Secreted Signaling 0.1009 0.0240370736712855 Scatter Plot
Source CD46 Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1038 0.020314351968112 Scatter Plot
Source CD46 Target RANKL RANKL Secreted Signaling 0.1072 0.0164625159093295 Scatter Plot
Source CD46 Source THY1 THY1 Cell-Cell Contact 0.1079 0.0157795532430747 Scatter Plot
Source CD46 Target CD86 CD86 Cell-Cell Contact 0.1081 0.0155508611103616 Scatter Plot
Source CD46 Target COLLAGEN COLLAGEN ECM-Receptor 0.1173 0.0086617583779019 Scatter Plot
Source CD46 Source CD39 CD39 Cell-Cell Contact 0.1184 0.0080587183213223 Scatter Plot
Source CD46 Target NCAM NCAM Cell-Cell Contact 0.1332 0.0028477305813956 Scatter Plot
Source CD46 Target THY1 THY1 Cell-Cell Contact 0.1369 0.002151261263955 Scatter Plot
Source CD46 Target CD23 CD23 Cell-Cell Contact 0.1396 0.0017542744949997 Scatter Plot
Source CD46 Source CD86 CD86 Cell-Cell Contact 0.1450 0.0011472509046501 Scatter Plot
Source CD46 Target MK MK Secreted Signaling 0.1453 0.0011255680111365 Scatter Plot
Source CD46 Target LAMININ LAMININ ECM-Receptor 0.1503 0.0007468591684337 Scatter Plot
Source CD46 Target GDF GDF Secreted Signaling 0.1513 0.0006906376932311 Scatter Plot
Source CD46 Target SEMA3 SEMA3 Secreted Signaling 0.1513 0.0006869817886919 Scatter Plot
Source CD46 Source CXCL CXCL Secreted Signaling 0.1679 0.0001621342023292 Scatter Plot
Source CD46 Source IL16 IL16 Secreted Signaling 0.1685 0.0001531662844051 Scatter Plot
Source CD46 Target SPP1 SPP1 Secreted Signaling 0.1695 0.0001393318614178 Scatter Plot
Source CD46 Target NODAL NODAL Secreted Signaling 0.1696 0.0001389623264086 Scatter Plot
Source CD46 Target FN1 FN1 ECM-Receptor 0.1763 0.00007360932109596261 Scatter Plot
Source CD46 Source CX3C CX3C Secreted Signaling 0.1804 0.0000495084489233165 Scatter Plot
Source CD46 Source GP1BA GP1BA Cell-Cell Contact 0.1882 0.000022887680670323504 Scatter Plot
Source CD46 Source IL2 IL2 Secreted Signaling 0.1902 0.00001864472130573301 Scatter Plot
Source CD46 Target VEGF VEGF Secreted Signaling 0.1913 0.000016521870443503137 Scatter Plot
Source CD46 Target KIT KIT Secreted Signaling 0.2012 0.000005808940705362244 Scatter Plot
Source CD46 Source CD45 CD45 Cell-Cell Contact 0.2023 0.00000511468336611232 Scatter Plot
Source CD46 Target CD22 CD22 Cell-Cell Contact 0.2023 0.00000511468336611232 Scatter Plot
Source CD46 Target EPHB EPHB Cell-Cell Contact 0.2067 0.000003139486881587225 Scatter Plot
Source CD46 Target SEMA6 SEMA6 Cell-Cell Contact 0.2082 0.0000026582389303737827 Scatter Plot
Source CD46 Target CD200 CD200 Cell-Cell Contact 0.2087 0.0000025036451980584947 Scatter Plot
Source CD46 Target TGFb TGFb Secreted Signaling 0.2102 0.000002113131521385962 Scatter Plot
Source CD46 Source IGF IGF Secreted Signaling 0.2105 0.0000020493671992106943 Scatter Plot
Source CD46 Source CCL CCL Secreted Signaling 0.2145 0.000001297146407872552 Scatter Plot
Source CD46 Target ACTIVIN ACTIVIN Secreted Signaling 0.2156 0.0000011426980407992238 Scatter Plot
Source CD46 Target OSM OSM Secreted Signaling 0.2179 0.00000086266050481285 Scatter Plot
Source CD46 Source CSF CSF Secreted Signaling 0.2192 0.000000747348592719362 Scatter Plot
Source CD46 Source ICAM ICAM Cell-Cell Contact 0.2224 0.0000005084383031063249 Scatter Plot
Source CD46 Target PTN PTN Secreted Signaling 0.2231 0.0000004648035452351568 Scatter Plot
Source CD46 Source NOTCH NOTCH Cell-Cell Contact 0.2271 0.0000002866874009982812 Scatter Plot
Source CD46 Target ANGPTL ANGPTL Secreted Signaling 0.2291 0.00000022176791812943645 Scatter Plot
Source CD46 Target CDH CDH Cell-Cell Contact 0.2322 0.00000015192676548703969 Scatter Plot
Source CD46 Source LCK LCK Cell-Cell Contact 0.2342 0.00000011705823960913788 Scatter Plot
Source CD46 Source MK MK Secreted Signaling 0.2355 0.0000000992009769506214 Scatter Plot
Source CD46 Target VISFATIN VISFATIN Secreted Signaling 0.2368 0.000000084086705270217 Scatter Plot
Source CD46 Target BAFF BAFF Secreted Signaling 0.2391 0.00000006232665716659548 Scatter Plot
Source CD46 Target SEMA7 SEMA7 Cell-Cell Contact 0.2413 0.00000004700799383306751 Scatter Plot
Source CD46 Target VTN VTN ECM-Receptor 0.2422 0.000000041510096126510654 Scatter Plot
Source CD46 Target ANGPT ANGPT Secreted Signaling 0.2447 0.0000000298281561969043 Scatter Plot
Source CD46 Target CSPG4 CSPG4 Cell-Cell Contact 0.2487 0.000000017421388652070297 Scatter Plot
Source CD46 Target SLURP SLURP Secreted Signaling 0.2495 0.00000001569887415426114 Scatter Plot
Source CD46 Target VWF VWF ECM-Receptor 0.2601 0.000000003562005609636205 Scatter Plot
Source CD46 Target AGT AGT Secreted Signaling 0.2674 0.0000000012305390282541203 Scatter Plot
Source CD46 Target SEMA4 SEMA4 Cell-Cell Contact 0.2684 0.0000000010668278484144183 Scatter Plot
Source CD46 Source FLT3 FLT3 Secreted Signaling 0.2722 0.0000000006056034676992 Scatter Plot
Source CD46 Target SEMA5 SEMA5 Cell-Cell Contact 0.2730 0.0000000005342652951921605 Scatter Plot
Source CD46 Target APP APP Cell-Cell Contact 0.2801 0.00000000018139733191367067 Scatter Plot
Source CD46 Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.2810 0.00000000015830634587277876 Scatter Plot
Source CD46 Target BMP BMP Secreted Signaling 0.2836 0.00000000010504127932209474 Scatter Plot
Source CD46 Target NPR2 NPR2 Secreted Signaling 0.2887 0.000000000047214978368465415 Scatter Plot
Source CD46 Target PERIOSTIN PERIOSTIN Secreted Signaling 0.2917 0.000000000028796095159620947 Scatter Plot
Source CD46 Target TENASCIN TENASCIN ECM-Receptor 0.2919 0.000000000028116894069069768 Scatter Plot
Source CD46 Target CADM CADM Cell-Cell Contact 0.2919 0.00000000002807099355457313 Scatter Plot
Source CD46 Source CADM CADM Cell-Cell Contact 0.2919 0.00000000002807099355457313 Scatter Plot
Source CD46 Source IL7 IL7 Secreted Signaling 0.2947 0.000000000017848811110970722 Scatter Plot
Source CD46 Target CD39 CD39 Cell-Cell Contact 0.3005 0.000000000006776344087080965 Scatter Plot
Source CD46 Target IGF IGF Secreted Signaling 0.3074 0.000000000002105117199325482 Scatter Plot
Source CD46 Target THBS THBS ECM-Receptor 0.3092 0.0000000000015288159445887525 Scatter Plot
Source CD46 Source BST2 BST2 Cell-Cell Contact 0.3099 0.0000000000013561413464086488 Scatter Plot
Source CD46 Target WNT WNT Secreted Signaling 0.3129 0.0000000000008000778026134506 Scatter Plot
Source CD46 Target BSP BSP ECM-Receptor 0.3141 0.0000000000006477086550605603 Scatter Plot
Source CD46 Target MIF MIF Secreted Signaling 0.3181 0.00000000000031970538608556853 Scatter Plot
Source CD46 Target DMP1 DMP1 ECM-Receptor 0.3210 0.00000000000019104173988588921 Scatter Plot
Source CD46 Source COLLAGEN COLLAGEN ECM-Receptor 0.3222 0.0000000000001512994844900533 Scatter Plot
Source CD46 Source SEMA7 SEMA7 Cell-Cell Contact 0.3232 0.00000000000012812140666415088 Scatter Plot
Source CD46 Target CD34 CD34 Cell-Cell Contact 0.3268 0.00000000000006587665140655427 Scatter Plot
Source CD46 Source ESAM ESAM Cell-Cell Contact 0.3269 0.00000000000006497685556660469 Scatter Plot
Source CD46 Target ESAM ESAM Cell-Cell Contact 0.3269 0.00000000000006497685556660353 Scatter Plot
Source CD46 Target NRG NRG Secreted Signaling 0.3291 0.000000000000042391980948305496 Scatter Plot
Source CD46 Target PARs PARs Secreted Signaling 0.3302 0.000000000000034970304269795595 Scatter Plot
Source CD46 Source MHC-II MHC-II Cell-Cell Contact 0.3317 0.000000000000026184478082676514 Scatter Plot
Source CD46 Target ncWNT ncWNT Secreted Signaling 0.3353 0.000000000000013264185436393835 Scatter Plot
Source CD46 Target FGF FGF Secreted Signaling 0.3397 0.0000000000000057105373944621976 Scatter Plot
Source CD46 Target JAM JAM Cell-Cell Contact 0.3604 0.00000000000000008723295388713542 Scatter Plot
Source CD46 Source MHC-I MHC-I Cell-Cell Contact 0.3854 0.00000000000000000037005442278274716 Scatter Plot
Source CD46 Source JAM JAM Cell-Cell Contact 0.3896 0.00000000000000000014291506175873512 Scatter Plot
Source CD46 Source CD52 CD52 Cell-Cell Contact -0.3325 0.000000000000022395950933755422 Scatter Plot
Source CD46 Source COMPLEMENT COMPLEMENT Secreted Signaling -0.2722 0.0000000006087382208007228 Scatter Plot
Source CD46 Target VCAM VCAM Cell-Cell Contact -0.2448 0.000000029479364560227395 Scatter Plot
Source CD46 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.2358 0.0000000956267308145746 Scatter Plot
Source CD46 Target ICAM ICAM Cell-Cell Contact -0.2169 0.0000009739682414685786 Scatter Plot
Source CD46 Source MIF MIF Secreted Signaling -0.1915 0.000016297614847089468 Scatter Plot
Source CD46 Target IFN-II IFN-II Secreted Signaling -0.1901 0.00001883729153656707 Scatter Plot
Source CD46 Target CD52 CD52 Cell-Cell Contact -0.1849 0.00003179939186447778 Scatter Plot
Source CD46 Target CCL CCL Secreted Signaling -0.1836 0.00003634536992784411 Scatter Plot
Source CD46 Source ANNEXIN ANNEXIN Secreted Signaling -0.1757 0.0000780137769391276 Scatter Plot
Source CD46 Target CXCL CXCL Secreted Signaling -0.1714 0.000117827339892 Scatter Plot
Source CD46 Target CLEC CLEC Cell-Cell Contact -0.1650 0.0002107713811547 Scatter Plot
Source CD46 Source CCL CCL Secreted Signaling -0.1621 0.0002722200318684 Scatter Plot
Source CD46 Source LAIR1 LAIR1 Cell-Cell Contact -0.1608 0.0003070645175844 Scatter Plot
Source CD46 Source SPP1 SPP1 Secreted Signaling -0.1602 0.00032139024124 Scatter Plot
Source CD46 Target IL17 IL17 Secreted Signaling -0.1596 0.0003397650897124 Scatter Plot
Source CD46 Source CLEC CLEC Cell-Cell Contact -0.1557 0.0004746255999756 Scatter Plot
Source CD46 Source SELPLG SELPLG Cell-Cell Contact -0.1413 0.0015380597933408 Scatter Plot
Source CD46 Target VEGF VEGF Secreted Signaling -0.1386 0.0019004777410883 Scatter Plot
Source CD46 Target CEACAM CEACAM Cell-Cell Contact -0.1275 0.0043054010667939 Scatter Plot
Source CD46 Source VISTA VISTA Cell-Cell Contact -0.1159 0.0094968453725689 Scatter Plot
Source CD46 Target ANNEXIN ANNEXIN Secreted Signaling -0.1073 0.0163556266799491 Scatter Plot
Source CD46 Target CSF CSF Secreted Signaling -0.1068 0.0168758885693768 Scatter Plot
Source CD46 Target COLLAGEN COLLAGEN ECM-Receptor -0.1058 0.0179973643982767 Scatter Plot

Cells that are targets of CD46 from HSCs*

Cells that are source of CD46 to HSCs*

    No cell populations

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.