Pathway: NT

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the NT pathway:

Specificity Index HSPC as target: 0.266
HSPC as source: 0.494

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the NT pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Source NT Source VEGF VEGF Secreted Signaling 0.1018 0.0228770706952092 Scatter Plot
Source NT Source APELIN APELIN Secreted Signaling 0.1048 0.0190893384394321 Scatter Plot
Source NT Source PECAM1 PECAM1 Cell-Cell Contact 0.1190 0.0077174867533087 Scatter Plot
Source NT Source EPHB EPHB Cell-Cell Contact 0.1453 0.0011246887502854 Scatter Plot
Source NT Source CD39 CD39 Cell-Cell Contact 0.1561 0.0004594133901427 Scatter Plot
Source NT Source LIGHT LIGHT Secreted Signaling 0.1625 0.0002638077245549 Scatter Plot
Source NT Source CCL CCL Secreted Signaling 0.1663 0.0001870557067094 Scatter Plot
Source NT Source SEMA3 SEMA3 Secreted Signaling 0.1701 0.000132645721087 Scatter Plot
Source NT Source CXCL CXCL Secreted Signaling 0.1728 0.000102761702282 Scatter Plot
Source NT Source SEMA6 SEMA6 Cell-Cell Contact 0.2077 0.000002825654441170501 Scatter Plot
Source NT Source CADM CADM Cell-Cell Contact 0.2092 0.0000023665060584348933 Scatter Plot
Source NT Source ncWNT ncWNT Secreted Signaling 0.2117 0.0000017859302923081772 Scatter Plot
Source NT Source CDH CDH Cell-Cell Contact 0.2521 0.000000010913979318472704 Scatter Plot
Source NT Source ANGPT ANGPT Secreted Signaling 0.2637 0.0000000021066044068121193 Scatter Plot
Source NT Source LIFR LIFR Secreted Signaling 0.2923 0.00000000002606150801832996 Scatter Plot
Source NT Source PROS PROS Secreted Signaling 0.3013 0.000000000005890631893774467 Scatter Plot
Source NT Source LAMININ LAMININ ECM-Receptor 0.3047 0.0000000000033079274215792428 Scatter Plot
Source NT Source RANKL RANKL Secreted Signaling 0.3196 0.00000000000024474951659806744 Scatter Plot
Source NT Source NOTCH NOTCH Cell-Cell Contact 0.3747 0.000000000000000004044712963312997 Scatter Plot
Source NT Source PDGF PDGF Secreted Signaling 0.4030 0.000000000000000000006008446106574709 Scatter Plot
Source NT Source TWEAK TWEAK Secreted Signaling 0.4122 0.0000000000000000000006229754168853827 Scatter Plot
Source NT Source BMP BMP Secreted Signaling 0.4365 0.0000000000000000000000011101316582530176 Scatter Plot
Source NT Source TGFb TGFb Secreted Signaling -0.2330 0.00000013586470870191366 Scatter Plot
Source NT Source SEMA4 SEMA4 Cell-Cell Contact -0.2026 0.000004959537675562053 Scatter Plot
Source NT Source CD34 CD34 Cell-Cell Contact -0.1629 0.0002552416593517 Scatter Plot
Source NT Source MIF MIF Secreted Signaling -0.1591 0.0003564661825814 Scatter Plot
Source NT Source ANGPTL ANGPTL Secreted Signaling -0.1581 0.0003862490771404 Scatter Plot
Source NT Source FGF FGF Secreted Signaling -0.1374 0.0020747657343759 Scatter Plot
Source NT Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.0982 0.0281896419071433 Scatter Plot
Source NT Source PTN PTN Secreted Signaling 0.1009 0.0240737920752235 Scatter Plot
Source NT Source GRN GRN Secreted Signaling 0.1035 0.0206105827316378 Scatter Plot
Source NT Target NODAL NODAL Secreted Signaling 0.1039 0.020140303679625 Scatter Plot
Source NT Target CD86 CD86 Cell-Cell Contact 0.1178 0.0083666102492542 Scatter Plot
Source NT Target PECAM1 PECAM1 Cell-Cell Contact 0.1190 0.0077174867533087 Scatter Plot
Source NT Source IL16 IL16 Secreted Signaling 0.1215 0.0065092921962637 Scatter Plot
Source NT Target COMPLEMENT COMPLEMENT Secreted Signaling 0.1258 0.0048532645145364 Scatter Plot
Source NT Target ACTIVIN ACTIVIN Secreted Signaling 0.1296 0.0037026016755692 Scatter Plot
Source NT Target BAFF BAFF Secreted Signaling 0.1306 0.0034404638234545 Scatter Plot
Source NT Target CD23 CD23 Cell-Cell Contact 0.1389 0.001843851600525 Scatter Plot
Source NT Source GP1BA GP1BA Cell-Cell Contact 0.1396 0.0017587564196624 Scatter Plot
Source NT Target CXCL CXCL Secreted Signaling 0.1409 0.0015888675088053 Scatter Plot
Source NT Source CD86 CD86 Cell-Cell Contact 0.1431 0.0013376353744471 Scatter Plot
Source NT Target THY1 THY1 Cell-Cell Contact 0.1462 0.0010467074554888 Scatter Plot
Source NT Target CSPG4 CSPG4 Cell-Cell Contact 0.1479 0.0009109622087499 Scatter Plot
Source NT Target NOTCH NOTCH Cell-Cell Contact 0.1511 0.0006974068714108 Scatter Plot
Source NT Target RANKL RANKL Secreted Signaling 0.1534 0.0005783531758133 Scatter Plot
Source NT Target TGFb TGFb Secreted Signaling 0.1667 0.0001800558407205 Scatter Plot
Source NT Target FN1 FN1 ECM-Receptor 0.1678 0.0001630501026855 Scatter Plot
Source NT Target NCAM NCAM Cell-Cell Contact 0.1729 0.000102405809526 Scatter Plot
Source NT Target LAMININ LAMININ ECM-Receptor 0.1742 0.0000904295393032639 Scatter Plot
Source NT Target BMP BMP Secreted Signaling 0.1745 0.0000879257991456218 Scatter Plot
Source NT Target MK MK Secreted Signaling 0.1839 0.00003499026752270803 Scatter Plot
Source NT Target IL6 IL6 Secreted Signaling 0.1846 0.00003264992630599486 Scatter Plot
Source NT Source CD45 CD45 Cell-Cell Contact 0.1854 0.00003033023459556997 Scatter Plot
Source NT Target CD22 CD22 Cell-Cell Contact 0.1854 0.00003033023459556997 Scatter Plot
Source NT Source ICAM ICAM Cell-Cell Contact 0.1883 0.00002250036809100562 Scatter Plot
Source NT Target CD200 CD200 Cell-Cell Contact 0.1886 0.00002196250232862361 Scatter Plot
Source NT Source CX3C CX3C Secreted Signaling 0.1904 0.000018185155636640704 Scatter Plot
Source NT Source IL2 IL2 Secreted Signaling 0.1915 0.000016192105950510135 Scatter Plot
Source NT Target PTN PTN Secreted Signaling 0.1967 0.000009381783753028491 Scatter Plot
Source NT Target VEGF VEGF Secreted Signaling 0.1974 0.000008723961797851509 Scatter Plot
Source NT Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.1978 0.00000831878505006678 Scatter Plot
Source NT Target SEMA4 SEMA4 Cell-Cell Contact 0.2013 0.0000057408188201817074 Scatter Plot
Source NT Source LCK LCK Cell-Cell Contact 0.2049 0.000003856935320897531 Scatter Plot
Source NT Target SPP1 SPP1 Secreted Signaling 0.2056 0.000003549487000667328 Scatter Plot
Source NT Target EPHA EPHA Cell-Cell Contact 0.2064 0.0000032622533049161086 Scatter Plot
Source NT Target SEMA6 SEMA6 Cell-Cell Contact 0.2072 0.000002970795599949699 Scatter Plot
Source NT Target SEMA7 SEMA7 Cell-Cell Contact 0.2074 0.0000029229851509694228 Scatter Plot
Source NT Target CADM CADM Cell-Cell Contact 0.2092 0.000002366506058434889 Scatter Plot
Source NT Source COLLAGEN COLLAGEN ECM-Receptor 0.2246 0.00000039026475059781195 Scatter Plot
Source NT Target SEMA5 SEMA5 Cell-Cell Contact 0.2260 0.0000003263914640762964 Scatter Plot
Source NT Target SELPLG SELPLG Cell-Cell Contact 0.2334 0.0000001289658727639727 Scatter Plot
Source NT Source CD46 CD46 Cell-Cell Contact 0.2356 0.00000009806852843361373 Scatter Plot
Source NT Target THBS THBS ECM-Receptor 0.2419 0.00000004329599653695341 Scatter Plot
Source NT Target ANGPTL ANGPTL Secreted Signaling 0.2477 0.00000001997440614643884 Scatter Plot
Source NT Target CDH CDH Cell-Cell Contact 0.2521 0.000000010913979318472704 Scatter Plot
Source NT Target MIF MIF Secreted Signaling 0.2560 0.0000000063813203275358605 Scatter Plot
Source NT Source IL7 IL7 Secreted Signaling 0.2615 0.0000000029150492860897193 Scatter Plot
Source NT Target SEMA3 SEMA3 Secreted Signaling 0.2673 0.0000000012623101337802643 Scatter Plot
Source NT Target VWF VWF ECM-Receptor 0.2689 0.0000000009913872494717908 Scatter Plot
Source NT Target ANGPT ANGPT Secreted Signaling 0.2697 0.0000000008825583002314687 Scatter Plot
Source NT Target VTN VTN ECM-Receptor 0.2712 0.0000000007023847514500643 Scatter Plot
Source NT Target VISFATIN VISFATIN Secreted Signaling 0.2726 0.0000000005703239280439357 Scatter Plot
Source NT Target CD39 CD39 Cell-Cell Contact 0.2737 0.0000000004836506172892634 Scatter Plot
Source NT Source PSAP PSAP Secreted Signaling 0.2773 0.00000000028203238543243005 Scatter Plot
Source NT Target FGF FGF Secreted Signaling 0.2793 0.00000000020642457426380962 Scatter Plot
Source NT Target PARs PARs Secreted Signaling 0.2841 0.00000000009679790155761778 Scatter Plot
Source NT Target EPHB EPHB Cell-Cell Contact 0.2885 0.000000000048458418795406755 Scatter Plot
Source NT Source GAS GAS Secreted Signaling 0.2913 0.000000000030997415614786083 Scatter Plot
Source NT Target APP APP Cell-Cell Contact 0.2919 0.000000000027917264072488457 Scatter Plot
Source NT Source MK MK Secreted Signaling 0.2926 0.00000000002520507387432697 Scatter Plot
Source NT Source MHC-II MHC-II Cell-Cell Contact 0.3007 0.000000000006522747422079858 Scatter Plot
Source NT Target NRG NRG Secreted Signaling 0.3032 0.000000000004333937200226967 Scatter Plot
Source NT Target PERIOSTIN PERIOSTIN Secreted Signaling 0.3104 0.000000000001250584506654126 Scatter Plot
Source NT Target TENASCIN TENASCIN ECM-Receptor 0.3137 0.0000000000007023445521485896 Scatter Plot
Source NT Target WNT WNT Secreted Signaling 0.3144 0.0000000000006171434857768754 Scatter Plot
Source NT Target BSP BSP ECM-Receptor 0.3188 0.00000000000028323897707736336 Scatter Plot
Source NT Target DMP1 DMP1 ECM-Receptor 0.3199 0.0000000000002337313998388341 Scatter Plot
Source NT Target ncWNT ncWNT Secreted Signaling 0.3228 0.0000000000001365868858854404 Scatter Plot
Source NT Source IGF IGF Secreted Signaling 0.3311 0.00000000000002960019877006222 Scatter Plot
Source NT Source CSF CSF Secreted Signaling 0.3422 0.0000000000000035056712593513203 Scatter Plot
Source NT Target OSM OSM Secreted Signaling 0.3476 0.0000000000000011934255661894858 Scatter Plot
Source NT Source SEMA7 SEMA7 Cell-Cell Contact 0.3498 0.0000000000000007689257653038748 Scatter Plot
Source NT Target NPR2 NPR2 Secreted Signaling 0.3521 0.000000000000000489041860756529 Scatter Plot
Source NT Target IGF IGF Secreted Signaling 0.3540 0.00000000000000033166038345763694 Scatter Plot
Source NT Target AGT AGT Secreted Signaling 0.3546 0.0000000000000002939617795483924 Scatter Plot
Source NT Target SLURP SLURP Secreted Signaling 0.3572 0.00000000000000016876701134109263 Scatter Plot
Source NT Source MHC-I MHC-I Cell-Cell Contact 0.3656 0.000000000000000029295385840191106 Scatter Plot
Source NT Source NOTCH NOTCH Cell-Cell Contact 0.3747 0.000000000000000004049952398483281 Scatter Plot
Source NT Target ESAM ESAM Cell-Cell Contact 0.3849 0.00000000000000000041866533717115943 Scatter Plot
Source NT Source ESAM ESAM Cell-Cell Contact 0.3849 0.00000000000000000041866533717115943 Scatter Plot
Source NT Source FLT3 FLT3 Secreted Signaling 0.3883 0.00000000000000000019235787203226542 Scatter Plot
Source NT Source BST2 BST2 Cell-Cell Contact 0.4200 0.00000000000000000000008591683188587861 Scatter Plot
Source NT Target JAM JAM Cell-Cell Contact 0.4374 0.0000000000000000000000008616925237194607 Scatter Plot
Source NT Source JAM JAM Cell-Cell Contact 0.4559 0.0000000000000000000000000048894321669366465 Scatter Plot
Source NT Target CD34 CD34 Cell-Cell Contact 0.4788 0.000000000000000000000000000005059051856828394 Scatter Plot
Source NT Source CD52 CD52 Cell-Cell Contact -0.3914 0.00000000000000000009288558551781549 Scatter Plot
Source NT Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.2924 0.000000000025847116641610512 Scatter Plot
Source NT Target ICAM ICAM Cell-Cell Contact -0.2821 0.0000000001335736624575197 Scatter Plot
Source NT Source SELL SELL Cell-Cell Contact -0.2390 0.00000006281552017113343 Scatter Plot
Source NT Source CCL CCL Secreted Signaling -0.2284 0.0000002439850256433892 Scatter Plot
Source NT Source COMPLEMENT COMPLEMENT Secreted Signaling -0.2264 0.0000003094723884064793 Scatter Plot
Source NT Target CXCL CXCL Secreted Signaling -0.2098 0.0000022167656056698165 Scatter Plot
Source NT Target VCAM VCAM Cell-Cell Contact -0.1957 0.00001049239481834828 Scatter Plot
Source NT Source SELPLG SELPLG Cell-Cell Contact -0.1822 0.00004181088204235781 Scatter Plot
Source NT Target COLLAGEN COLLAGEN ECM-Receptor -0.1800 0.00005160243014901783 Scatter Plot
Source NT Source PARs PARs Secreted Signaling -0.1690 0.0001463688626705 Scatter Plot
Source NT Target CD52 CD52 Cell-Cell Contact -0.1665 0.0001847605555151 Scatter Plot
Source NT Source CLEC CLEC Cell-Cell Contact -0.1580 0.0003897747192499 Scatter Plot
Source NT Target SELL SELL Cell-Cell Contact -0.1551 0.0005022254950202 Scatter Plot
Source NT Target CCL CCL Secreted Signaling -0.1461 0.0010509921511805 Scatter Plot
Source NT Target CLEC CLEC Cell-Cell Contact -0.1446 0.0011898456969862 Scatter Plot
Source NT Target CEACAM CEACAM Cell-Cell Contact -0.1382 0.0019479899815279 Scatter Plot
Source NT Source SPP1 SPP1 Secreted Signaling -0.1382 0.0019562675438396 Scatter Plot
Source NT Source NKG2D NKG2D Cell-Cell Contact -0.1356 0.002380028131546 Scatter Plot
Source NT Source ANNEXIN ANNEXIN Secreted Signaling -0.1299 0.0036218094852646 Scatter Plot
Source NT Source TNF TNF Secreted Signaling -0.1280 0.0041536894485129 Scatter Plot
Source NT Target VEGF VEGF Secreted Signaling -0.1248 0.0051795470607514 Scatter Plot
Source NT Source VISTA VISTA Cell-Cell Contact -0.1242 0.0054196896487227 Scatter Plot
Source NT Target ANNEXIN ANNEXIN Secreted Signaling -0.1190 0.0077254252424239 Scatter Plot
Source NT Target GRN GRN Secreted Signaling -0.1092 0.0146057284304836 Scatter Plot
Source NT Source LAIR1 LAIR1 Cell-Cell Contact -0.1063 0.0174566866781 Scatter Plot
Source NT Target IFN-II IFN-II Secreted Signaling -0.1060 0.0177204150164192 Scatter Plot
Source NT Source IL1 IL1 Secreted Signaling -0.0997 0.0257282558298907 Scatter Plot

Cells that are targets of NT from HSCs*

Cells that are source of NT to HSCs*

    No cell populations

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.