Pathway: NRG

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the NRG pathway:

Specificity Index HSPC as target: 0.263
HSPC as source: 0.823

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the NRG pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target NRG Source IL6 IL6 Secreted Signaling 0.1025 0.0218743038652875 Scatter Plot
Target NRG Source SEMA6 SEMA6 Cell-Cell Contact 0.1108 0.0131601393870914 Scatter Plot
Target NRG Source APELIN APELIN Secreted Signaling 0.1255 0.0049572495183677 Scatter Plot
Target NRG Source ANGPTL ANGPTL Secreted Signaling 0.1291 0.0038379479255577 Scatter Plot
Target NRG Source GDF GDF Secreted Signaling 0.1328 0.0029369216529253 Scatter Plot
Target NRG Target GALECTIN GALECTIN Secreted Signaling 0.1350 0.0024838792650404 Scatter Plot
Target NRG Source THBS THBS ECM-Receptor 0.1451 0.0011420801796265 Scatter Plot
Target NRG Target GAS GAS Secreted Signaling 0.1492 0.0008164586470755 Scatter Plot
Target NRG Target RANKL RANKL Secreted Signaling 0.1510 0.0007050909821815 Scatter Plot
Target NRG Source WNT WNT Secreted Signaling 0.1513 0.0006905005137005 Scatter Plot
Target NRG Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1613 0.0002918498068283 Scatter Plot
Target NRG Source PTN PTN Secreted Signaling 0.1639 0.0002335228798294 Scatter Plot
Target NRG Target VEGF VEGF Secreted Signaling 0.1639 0.0002323264707563 Scatter Plot
Target NRG Target AGT AGT Secreted Signaling 0.1818 0.000043087635032467945 Scatter Plot
Target NRG Target NCAM NCAM Cell-Cell Contact 0.1868 0.000026200281127219607 Scatter Plot
Target NRG Source GP1BA GP1BA Cell-Cell Contact 0.1891 0.000020705070310648423 Scatter Plot
Target NRG Source CD1D2 CD1D2 Cell-Cell Contact 0.1954 0.000010770305637438384 Scatter Plot
Target NRG Target EPHA EPHA Cell-Cell Contact 0.2081 0.000002704642460181055 Scatter Plot
Target NRG Target SEMA3 SEMA3 Secreted Signaling 0.2086 0.0000025501307451690678 Scatter Plot
Target NRG Target NODAL NODAL Secreted Signaling 0.2127 0.000001593122949687248 Scatter Plot
Target NRG Target GDF GDF Secreted Signaling 0.2140 0.000001367454294382616 Scatter Plot
Target NRG Source VCAM VCAM Cell-Cell Contact 0.2216 0.0000005552755175259004 Scatter Plot
Target NRG Source CD39 CD39 Cell-Cell Contact 0.2251 0.0000003649092975601729 Scatter Plot
Target NRG Source CCL CCL Secreted Signaling 0.2426 0.000000039240492753304454 Scatter Plot
Target NRG Source ncWNT ncWNT Secreted Signaling 0.2477 0.000000019949983596819373 Scatter Plot
Target NRG Source IL2 IL2 Secreted Signaling 0.2554 0.0000000068751388678179915 Scatter Plot
Target NRG Source SEMA3 SEMA3 Secreted Signaling 0.2578 0.000000004902271582252315 Scatter Plot
Target NRG Source THY1 THY1 Cell-Cell Contact 0.2661 0.0000000015061170019515803 Scatter Plot
Target NRG Source IL16 IL16 Secreted Signaling 0.2692 0.0000000009477284750462896 Scatter Plot
Target NRG Source CXCL CXCL Secreted Signaling 0.2797 0.00000000019278653799636407 Scatter Plot
Target NRG Target CSPG4 CSPG4 Cell-Cell Contact 0.2823 0.00000000012879734455911612 Scatter Plot
Target NRG Target IL6 IL6 Secreted Signaling 0.2849 0.00000000008535228572429389 Scatter Plot
Target NRG Source RANKL RANKL Secreted Signaling 0.2881 0.00000000005182789837182142 Scatter Plot
Target NRG Source EPHB EPHB Cell-Cell Contact 0.2902 0.00000000003673356252323349 Scatter Plot
Target NRG Target CADM CADM Cell-Cell Contact 0.2920 0.00000000002769602941876746 Scatter Plot
Target NRG Source CADM CADM Cell-Cell Contact 0.2920 0.00000000002769602941876746 Scatter Plot
Target NRG Target MK MK Secreted Signaling 0.2928 0.0000000000241051914108888 Scatter Plot
Target NRG Source NOTCH NOTCH Cell-Cell Contact 0.2947 0.000000000017847189545084705 Scatter Plot
Target NRG Target OSM OSM Secreted Signaling 0.2965 0.000000000013194647901263848 Scatter Plot
Target NRG Target COMPLEMENT COMPLEMENT Secreted Signaling 0.3024 0.000000000004906104898731439 Scatter Plot
Target NRG Source NT NT Secreted Signaling 0.3032 0.000000000004333937200226967 Scatter Plot
Target NRG Target SEMA7 SEMA7 Cell-Cell Contact 0.3039 0.000000000003805482833328119 Scatter Plot
Target NRG Target SEMA6 SEMA6 Cell-Cell Contact 0.3074 0.000000000002089654909181235 Scatter Plot
Target NRG Target KIT KIT Secreted Signaling 0.3078 0.0000000000019722605283783896 Scatter Plot
Target NRG Target EPHB EPHB Cell-Cell Contact 0.3095 0.0000000000014707445691234372 Scatter Plot
Target NRG Source CSF CSF Secreted Signaling 0.3145 0.0000000000006087471009903202 Scatter Plot
Target NRG Target SEMA5 SEMA5 Cell-Cell Contact 0.3160 0.0000000000004694805108554141 Scatter Plot
Target NRG Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.3184 0.00000000000030394708818637004 Scatter Plot
Target NRG Source VEGF VEGF Secreted Signaling 0.3196 0.0000000000002460173853968846 Scatter Plot
Target NRG Source LIGHT LIGHT Secreted Signaling 0.3238 0.00000000000011416627055848682 Scatter Plot
Target NRG Source CD46 CD46 Cell-Cell Contact 0.3291 0.000000000000042391980948305496 Scatter Plot
Target NRG Target ACTIVIN ACTIVIN Secreted Signaling 0.3402 0.00000000000000512855613911617 Scatter Plot
Target NRG Source CD86 CD86 Cell-Cell Contact 0.3415 0.000000000000003971219799399412 Scatter Plot
Target NRG Target VISFATIN VISFATIN Secreted Signaling 0.3466 0.0000000000000014637701930235901 Scatter Plot
Target NRG Source IGF IGF Secreted Signaling 0.3612 0.00000000000000007421059196313109 Scatter Plot
Target NRG Source CX3C CX3C Secreted Signaling 0.3692 0.000000000000000013598824549080862 Scatter Plot
Target NRG Source CD45 CD45 Cell-Cell Contact 0.3693 0.00000000000000001338153615033816 Scatter Plot
Target NRG Target CD22 CD22 Cell-Cell Contact 0.3693 0.00000000000000001338153615033816 Scatter Plot
Target NRG Source LCK LCK Cell-Cell Contact 0.3716 0.000000000000000008049345369660515 Scatter Plot
Target NRG Target BMP BMP Secreted Signaling 0.3768 0.0000000000000000025917930745628307 Scatter Plot
Target NRG Target CD200 CD200 Cell-Cell Contact 0.3787 0.0000000000000000016830448357412388 Scatter Plot
Target NRG Target PARs PARs Secreted Signaling 0.3809 0.0000000000000000010280365861623054 Scatter Plot
Target NRG Source FLT3 FLT3 Secreted Signaling 0.3813 0.0000000000000000009377305953861777 Scatter Plot
Target NRG Source ICAM ICAM Cell-Cell Contact 0.3938 0.00000000000000000005292890528157144 Scatter Plot
Target NRG Source LAMININ LAMININ ECM-Receptor 0.3939 0.000000000000000000052002969618560286 Scatter Plot
Target NRG Source BST2 BST2 Cell-Cell Contact 0.4103 0.0000000000000000000010044483470245573 Scatter Plot
Target NRG Source PROS PROS Secreted Signaling 0.4205 0.00000000000000000000007497515530185324 Scatter Plot
Target NRG Target APP APP Cell-Cell Contact 0.4219 0.00000000000000000000005313142747165744 Scatter Plot
Target NRG Source PSAP PSAP Secreted Signaling 0.4256 0.00000000000000000000002024744549349837 Scatter Plot
Target NRG Target NPR2 NPR2 Secreted Signaling 0.4317 0.0000000000000000000000040088869968860905 Scatter Plot
Target NRG Source MK MK Secreted Signaling 0.4340 0.0000000000000000000000021862816153607797 Scatter Plot
Target NRG Source CDH CDH Cell-Cell Contact 0.4399 0.0000000000000000000000004374300722112716 Scatter Plot
Target NRG Target CDH CDH Cell-Cell Contact 0.4399 0.0000000000000000000000004374300722112716 Scatter Plot
Target NRG Target SLURP SLURP Secreted Signaling 0.4424 0.0000000000000000000000002196673540813277 Scatter Plot
Target NRG Target ANGPT ANGPT Secreted Signaling 0.4444 0.00000000000000000000000012674273074518082 Scatter Plot
Target NRG Source PDGF PDGF Secreted Signaling 0.4446 0.00000000000000000000000012012253471382668 Scatter Plot
Target NRG Source COLLAGEN COLLAGEN ECM-Receptor 0.4493 0.000000000000000000000000032175363211933646 Scatter Plot
Target NRG Source LIFR LIFR Secreted Signaling 0.4713 0.00000000000000000000000000005046402131763885 Scatter Plot
Target NRG Source SEMA7 SEMA7 Cell-Cell Contact 0.4795 0.000000000000000000000000000004038084384621621 Scatter Plot
Target NRG Source IL7 IL7 Secreted Signaling 0.4874 0.0000000000000000000000000000003328493040512341 Scatter Plot
Target NRG Target ncWNT ncWNT Secreted Signaling 0.4904 0.00000000000000000000000000000012727951107470318 Scatter Plot
Target NRG Target FGF FGF Secreted Signaling 0.4973 0.000000000000000000000000000000013241077124446823 Scatter Plot
Target NRG Source ANGPT ANGPT Secreted Signaling 0.4988 0.000000000000000000000000000000008075013344071579 Scatter Plot
Target NRG Target CD39 CD39 Cell-Cell Contact 0.4989 0.000000000000000000000000000000007879136981739 Scatter Plot
Target NRG Source BMP BMP Secreted Signaling 0.5063 0.0000000000000000000000000000000006428127801081469 Scatter Plot
Target NRG Target MIF MIF Secreted Signaling 0.5135 0.00000000000000000000000000000000005390374750354387 Scatter Plot
Target NRG Source GAS GAS Secreted Signaling 0.5184 0.000000000000000000000000000000000009615342081846829 Scatter Plot
Target NRG Source TWEAK TWEAK Secreted Signaling 0.5288 0.00000000000000000000000000000000000021969554448503303 Scatter Plot
Target NRG Target WNT WNT Secreted Signaling 0.5349 0.0000000000000000000000000000000000000231817775071322 Scatter Plot
Target NRG Target ESAM ESAM Cell-Cell Contact 0.5356 0.00000000000000000000000000000000000001749767657882542 Scatter Plot
Target NRG Source ESAM ESAM Cell-Cell Contact 0.5356 0.00000000000000000000000000000000000001749767657882542 Scatter Plot
Target NRG Source MHC-II MHC-II Cell-Cell Contact 0.5378 0.000000000000000000000000000000000000007658340276476197 Scatter Plot
Target NRG Target CD34 CD34 Cell-Cell Contact 0.5388 0.000000000000000000000000000000000000005298560665703186 Scatter Plot
Target NRG Source MHC-I MHC-I Cell-Cell Contact 0.5457 0.0000000000000000000000000000000000000003674049492813373 Scatter Plot
Target NRG Source JAM JAM Cell-Cell Contact 0.5826 0.00000000000000000000000000000000000000000000008406340582658536 Scatter Plot
Target NRG Source CD52 CD52 Cell-Cell Contact -0.3880 0.00000000000000000020482283459433272 Scatter Plot
Target NRG Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.3383 0.000000000000007489368714856453 Scatter Plot
Target NRG Source SELL SELL Cell-Cell Contact -0.3288 0.000000000000045470435305145066 Scatter Plot
Target NRG Target ICAM ICAM Cell-Cell Contact -0.3257 0.00000000000008001963303638593 Scatter Plot
Target NRG Source COMPLEMENT COMPLEMENT Secreted Signaling -0.3062 0.00000000000259340495953458 Scatter Plot
Target NRG Source PARs PARs Secreted Signaling -0.2831 0.00000000011344539629626102 Scatter Plot
Target NRG Target CD52 CD52 Cell-Cell Contact -0.2761 0.0000000003340171753153732 Scatter Plot
Target NRG Source TGFb TGFb Secreted Signaling -0.2576 0.00000000503779664215663 Scatter Plot
Target NRG Target VCAM VCAM Cell-Cell Contact -0.2517 0.000000011470545137828832 Scatter Plot
Target NRG Source CLEC CLEC Cell-Cell Contact -0.2364 0.00000008864598820169156 Scatter Plot
Target NRG Source ANGPTL ANGPTL Secreted Signaling -0.2309 0.00000017898266167383204 Scatter Plot
Target NRG Source MIF MIF Secreted Signaling -0.2200 0.0000006754534016238536 Scatter Plot
Target NRG Target CEACAM CEACAM Cell-Cell Contact -0.2027 0.000004879700490761422 Scatter Plot
Target NRG Target CCL CCL Secreted Signaling -0.1907 0.000017606760920142153 Scatter Plot
Target NRG Source CCL CCL Secreted Signaling -0.1836 0.00003618539160273568 Scatter Plot
Target NRG Source NCAM NCAM Cell-Cell Contact -0.1798 0.000052846302595617287 Scatter Plot
Target NRG Source VISTA VISTA Cell-Cell Contact -0.1794 0.000054750416223732485 Scatter Plot
Target NRG Target VEGF VEGF Secreted Signaling -0.1755 0.00007994468722516912 Scatter Plot
Target NRG Source SPP1 SPP1 Secreted Signaling -0.1720 0.0001112720123473 Scatter Plot
Target NRG Source SEMA4 SEMA4 Cell-Cell Contact -0.1676 0.0001661821843055 Scatter Plot
Target NRG Target CXCL CXCL Secreted Signaling -0.1525 0.000623070581624 Scatter Plot
Target NRG Target CSF CSF Secreted Signaling -0.1495 0.0007955803505281 Scatter Plot
Target NRG Source TNF TNF Secreted Signaling -0.1222 0.0062175425644711 Scatter Plot
Target NRG Source NKG2D NKG2D Cell-Cell Contact -0.1211 0.0067116854345253 Scatter Plot
Target NRG Target GRN GRN Secreted Signaling -0.1202 0.0071494411986678 Scatter Plot
Target NRG Target IL17 IL17 Secreted Signaling -0.1187 0.0078795644241002 Scatter Plot
Target NRG Source ANNEXIN ANNEXIN Secreted Signaling -0.1150 0.0100959964897804 Scatter Plot
Target NRG Target ANNEXIN ANNEXIN Secreted Signaling -0.1005 0.0246218912323977 Scatter Plot
Target NRG Target NODAL NODAL Secreted Signaling 0.2127 0.000001593122949687248 Scatter Plot
Target NRG Target TGFb TGFb Secreted Signaling 0.3631 0.000000000000000049592733780280613 Scatter Plot
Target NRG Target BAFF BAFF Secreted Signaling 0.3701 0.000000000000000011170694861430452 Scatter Plot
Target NRG Target SEMA4 SEMA4 Cell-Cell Contact 0.3942 0.0000000000000000000482639423168039 Scatter Plot
Target NRG Target IFN-II IFN-II Secreted Signaling -0.2219 0.0000005403953999260838 Scatter Plot

Cells that are targets of NRG from HSCs*

    No cell populations

Cells that are source of NRG to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.