Pathway: SEMA3

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the SEMA3 pathway:

Specificity Index HSPC as target: 0.133
HSPC as source: 0.261

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the SEMA3 pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target SEMA3 Source LIGHT LIGHT Secreted Signaling 0.0988 0.0271491070531923 Scatter Plot
Target SEMA3 Source EPHB EPHB Cell-Cell Contact 0.1010 0.0238440345671995 Scatter Plot
Target SEMA3 Source IL16 IL16 Secreted Signaling 0.1021 0.0224165944293157 Scatter Plot
Source SEMA3 Source OSM OSM Secreted Signaling 0.1026 0.0217088788818644 Scatter Plot
Source SEMA3 Source VCAM VCAM Cell-Cell Contact 0.1040 0.0200755359908469 Scatter Plot
Target SEMA3 Source CX3C CX3C Secreted Signaling 0.1047 0.0192236658711053 Scatter Plot
Target SEMA3 Source PTN PTN Secreted Signaling 0.1048 0.0191128636900515 Scatter Plot
Target SEMA3 Target SLURP SLURP Secreted Signaling 0.1054 0.0184081276438861 Scatter Plot
Target SEMA3 Source AGRN AGRN ECM-Receptor 0.1073 0.016432230806125 Scatter Plot
Target SEMA3 Source NOTCH NOTCH Cell-Cell Contact 0.1086 0.015121520356405 Scatter Plot
Target SEMA3 Target COLLAGEN COLLAGEN ECM-Receptor 0.1116 0.012560581320217 Scatter Plot
Target SEMA3 Source VISFATIN VISFATIN Secreted Signaling 0.1117 0.0124704794139062 Scatter Plot
Source SEMA3 Source ncWNT ncWNT Secreted Signaling 0.1138 0.0108563282248926 Scatter Plot
Target SEMA3 Source LIFR LIFR Secreted Signaling 0.1141 0.010689071751822 Scatter Plot
Source SEMA3 Source IL6 IL6 Secreted Signaling 0.1148 0.0101987958000994 Scatter Plot
Target SEMA3 Source ncWNT ncWNT Secreted Signaling 0.1149 0.0101540466917267 Scatter Plot
Source SEMA3 Source GDF GDF Secreted Signaling 0.1163 0.0092283971946327 Scatter Plot
Target SEMA3 Source MIF MIF Secreted Signaling 0.1192 0.0076364306460625 Scatter Plot
Target SEMA3 Source IL2 IL2 Secreted Signaling 0.1198 0.0073014590400429 Scatter Plot
Target SEMA3 Source IL7 IL7 Secreted Signaling 0.1198 0.0073014590400429 Scatter Plot
Source SEMA3 Source PTN PTN Secreted Signaling 0.1247 0.0052422795470139 Scatter Plot
Target SEMA3 Source IL6 IL6 Secreted Signaling 0.1247 0.0052216868463945 Scatter Plot
Target SEMA3 Source COLLAGEN COLLAGEN ECM-Receptor 0.1275 0.0042995437680091 Scatter Plot
Target SEMA3 Source CD1D2 CD1D2 Cell-Cell Contact 0.1279 0.0041619422339877 Scatter Plot
Target SEMA3 Source BAFF BAFF Secreted Signaling 0.1288 0.0039022211859862 Scatter Plot
Target SEMA3 Source TNF TNF Secreted Signaling 0.1289 0.003880628056437 Scatter Plot
Target SEMA3 Source CD45 CD45 Cell-Cell Contact 0.1304 0.0034929301300462 Scatter Plot
Target SEMA3 Source MHC-I MHC-I Cell-Cell Contact 0.1330 0.0028949705060261 Scatter Plot
Target SEMA3 Target VWF VWF ECM-Receptor 0.1342 0.0026462047184967 Scatter Plot
Target SEMA3 Source ICAM ICAM Cell-Cell Contact 0.1342 0.0026347492325039 Scatter Plot
Source SEMA3 Source PROS PROS Secreted Signaling 0.1361 0.0022807077606346 Scatter Plot
Target SEMA3 Source LAMININ LAMININ ECM-Receptor 0.1402 0.0016775697128797 Scatter Plot
Target SEMA3 Target ANGPT ANGPT Secreted Signaling 0.1430 0.0013438952980836 Scatter Plot
Target SEMA3 Source CLEC CLEC Cell-Cell Contact 0.1453 0.0011186955881752 Scatter Plot
Target SEMA3 Source SEMA6 SEMA6 Cell-Cell Contact 0.1463 0.0010381950511119 Scatter Plot
Target SEMA3 Source ANGPTL ANGPTL Secreted Signaling 0.1470 0.0009817969198756 Scatter Plot
Target SEMA3 Target GAS GAS Secreted Signaling 0.1490 0.0008283468497442 Scatter Plot
Target SEMA3 Source CCL CCL Secreted Signaling 0.1505 0.0007340041374416 Scatter Plot
Target SEMA3 Source CD46 CD46 Cell-Cell Contact 0.1513 0.0006869817886919 Scatter Plot
Target SEMA3 Source CD86 CD86 Cell-Cell Contact 0.1514 0.0006832923094728 Scatter Plot
Target SEMA3 Source SELPLG SELPLG Cell-Cell Contact 0.1536 0.0005691055772194 Scatter Plot
Target SEMA3 Source PDGF PDGF Secreted Signaling 0.1545 0.0005273702802372 Scatter Plot
Target SEMA3 Source ICOS ICOS Cell-Cell Contact 0.1549 0.0005094873997902 Scatter Plot
Target SEMA3 Source RANKL RANKL Secreted Signaling 0.1565 0.0004424862555451 Scatter Plot
Target SEMA3 Source ANGPT ANGPT Secreted Signaling 0.1570 0.0004237530471784 Scatter Plot
Target SEMA3 Source WNT WNT Secreted Signaling 0.1572 0.0004188952941936 Scatter Plot
Target SEMA3 Source MK MK Secreted Signaling 0.1587 0.0003670322841152 Scatter Plot
Source SEMA3 Source LIGHT LIGHT Secreted Signaling 0.1617 0.000281826956075 Scatter Plot
Target SEMA3 Source PSAP PSAP Secreted Signaling 0.1642 0.000225865939934 Scatter Plot
Target SEMA3 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1678 0.0001631767294082 Scatter Plot
Target SEMA3 Source ESAM ESAM Cell-Cell Contact 0.1685 0.0001540084546368 Scatter Plot
Target SEMA3 Target IL17 IL17 Secreted Signaling 0.1715 0.0001163610414015 Scatter Plot
Target SEMA3 Source MHC-II MHC-II Cell-Cell Contact 0.1716 0.0001156235965337 Scatter Plot
Source SEMA3 Source LIFR LIFR Secreted Signaling 0.1748 0.00008529649316994214 Scatter Plot
Target SEMA3 Source BST2 BST2 Cell-Cell Contact 0.1758 0.00007735625190728414 Scatter Plot
Target SEMA3 Source CSF CSF Secreted Signaling 0.1780 0.00006278926346145969 Scatter Plot
Target SEMA3 Target ICAM ICAM Cell-Cell Contact 0.1791 0.00005624181653477576 Scatter Plot
Target SEMA3 Target GDF GDF Secreted Signaling 0.1797 0.00005330273155106981 Scatter Plot
Target SEMA3 Source CADM CADM Cell-Cell Contact 0.1814 0.00004501538827526434 Scatter Plot
Source SEMA3 Source VEGF VEGF Secreted Signaling 0.1840 0.00003479800024294175 Scatter Plot
Target SEMA3 Target COMPLEMENT COMPLEMENT Secreted Signaling 0.1863 0.00002773413947310279 Scatter Plot
Target SEMA3 Target CD39 CD39 Cell-Cell Contact 0.1885 0.00002219677261617656 Scatter Plot
Target SEMA3 Source GAS GAS Secreted Signaling 0.1890 0.000020906736976862965 Scatter Plot
Target SEMA3 Source SPP1 SPP1 Secreted Signaling 0.1902 0.00001856864518837714 Scatter Plot
Target SEMA3 Target CD34 CD34 Cell-Cell Contact 0.1905 0.000017946058685348726 Scatter Plot
Target SEMA3 Source NCAM NCAM Cell-Cell Contact 0.1939 0.000012573257915782816 Scatter Plot
Target SEMA3 Target CEACAM CEACAM Cell-Cell Contact 0.1950 0.000011275562547468878 Scatter Plot
Target SEMA3 Source IGF IGF Secreted Signaling 0.1971 0.000008989458067046257 Scatter Plot
Target SEMA3 Source PROS PROS Secreted Signaling 0.1981 0.000008105372621521322 Scatter Plot
Target SEMA3 Target EPHB EPHB Cell-Cell Contact 0.1981 0.00000810231379692292 Scatter Plot
Source SEMA3 Source RANKL RANKL Secreted Signaling 0.1997 0.000006780347955228688 Scatter Plot
Target SEMA3 Source CDH CDH Cell-Cell Contact 0.2057 0.0000035353169953780085 Scatter Plot
Target SEMA3 Source SEMA7 SEMA7 Cell-Cell Contact 0.2063 0.0000032884963229558194 Scatter Plot
Target SEMA3 Source GRN GRN Secreted Signaling 0.2093 0.0000023589011823820367 Scatter Plot
Target SEMA3 Target BMP BMP Secreted Signaling 0.2116 0.0000018079372133659528 Scatter Plot
Target SEMA3 Source SEMA4 SEMA4 Cell-Cell Contact 0.2146 0.000001276456311093445 Scatter Plot
Target SEMA3 Source JAM JAM Cell-Cell Contact 0.2185 0.0000008117327941832123 Scatter Plot
Target SEMA3 Source CXCL CXCL Secreted Signaling 0.2193 0.0000007327679807101514 Scatter Plot
Target SEMA3 Source APP APP Cell-Cell Contact 0.2278 0.00000026338593819594775 Scatter Plot
Target SEMA3 Source PARs PARs Secreted Signaling 0.2328 0.00000014040845037256113 Scatter Plot
Target SEMA3 Source BMP BMP Secreted Signaling 0.2328 0.0000001395088730192939 Scatter Plot
Source SEMA3 Source TWEAK TWEAK Secreted Signaling 0.2334 0.0000001302764643509877 Scatter Plot
Source SEMA3 Source ANGPT ANGPT Secreted Signaling 0.2367 0.00000008466784944032512 Scatter Plot
Target SEMA3 Source LAIR1 LAIR1 Cell-Cell Contact 0.2415 0.00000004554541342784631 Scatter Plot
Target SEMA3 Source SELL SELL Cell-Cell Contact 0.2427 0.00000003901498139411396 Scatter Plot
Target SEMA3 Source TWEAK TWEAK Secreted Signaling 0.2443 0.00000003141459696865808 Scatter Plot
Target SEMA3 Source ANNEXIN ANNEXIN Secreted Signaling 0.2650 0.0000000017578245388962691 Scatter Plot
Source SEMA3 Source CDH CDH Cell-Cell Contact 0.2656 0.000000001602732561192976 Scatter Plot
Target SEMA3 Source NT NT Secreted Signaling 0.2673 0.0000000012623101337802643 Scatter Plot
Target SEMA3 Source CD52 CD52 Cell-Cell Contact 0.2715 0.0000000006729625389680094 Scatter Plot
Source SEMA3 Source WNT WNT Secreted Signaling 0.2846 0.00000000009011142508232471 Scatter Plot
Target SEMA3 Source COMPLEMENT COMPLEMENT Secreted Signaling 0.2922 0.00000000002651622965693284 Scatter Plot
Target SEMA3 Source VISTA VISTA Cell-Cell Contact 0.3591 0.00000000000000011594542251620422 Scatter Plot
Target SEMA3 Source ANGPT ANGPT Secreted Signaling -0.2291 0.0000002235119266455104 Scatter Plot
Target SEMA3 Source EPHB EPHB Cell-Cell Contact -0.2255 0.0000003479946929963416 Scatter Plot
Target SEMA3 Source FLT3 FLT3 Secreted Signaling -0.2146 0.0000012845083725596129 Scatter Plot
Target SEMA3 Source MHC-I MHC-I Cell-Cell Contact -0.1892 0.00002056465452489284 Scatter Plot
Target SEMA3 Source LCK LCK Cell-Cell Contact -0.1890 0.00002090670839117687 Scatter Plot
Target SEMA3 Source CCL CCL Secreted Signaling -0.1819 0.00004279312698122676 Scatter Plot
Source SEMA3 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.1807 0.00004845923108476752 Scatter Plot
Target SEMA3 Source VCAM VCAM Cell-Cell Contact -0.1764 0.00007347064070104593 Scatter Plot
Target SEMA3 Source GALECTIN GALECTIN Secreted Signaling -0.1745 0.0000876990906954776 Scatter Plot
Target SEMA3 Source CXCL CXCL Secreted Signaling -0.1716 0.0001150047542722 Scatter Plot
Target SEMA3 Source COLLAGEN COLLAGEN ECM-Receptor -0.1711 0.0001204862723194 Scatter Plot
Target SEMA3 Source FGF FGF Secreted Signaling -0.1704 0.0001288389157899 Scatter Plot
Target SEMA3 Source GP1BA GP1BA Cell-Cell Contact -0.1625 0.0002626147670029 Scatter Plot
Target SEMA3 Source VEGF VEGF Secreted Signaling -0.1586 0.000370705754564 Scatter Plot
Target SEMA3 Target THBS THBS ECM-Receptor -0.1557 0.0004767668946449 Scatter Plot
Target SEMA3 Target SPP1 SPP1 Secreted Signaling -0.1391 0.001823900237436 Scatter Plot
Target SEMA3 Target VWF VWF ECM-Receptor -0.1386 0.0018947307485703 Scatter Plot
Target SEMA3 Source ANGPTL ANGPTL Secreted Signaling -0.1379 0.0019974285691798 Scatter Plot
Target SEMA3 Target ESAM ESAM Cell-Cell Contact -0.1369 0.0021548966954672 Scatter Plot
Target SEMA3 Source ESAM ESAM Cell-Cell Contact -0.1369 0.0021548966954672 Scatter Plot
Target SEMA3 Source TGFb TGFb Secreted Signaling -0.1298 0.0036359991114443 Scatter Plot
Source SEMA3 Source SELL SELL Cell-Cell Contact -0.1266 0.0045909524407421 Scatter Plot
Target SEMA3 Source LIFR LIFR Secreted Signaling -0.1245 0.0052977300202159 Scatter Plot
Source SEMA3 Source ANGPTL ANGPTL Secreted Signaling -0.1237 0.0056279523590073 Scatter Plot
Target SEMA3 Target CSPG4 CSPG4 Cell-Cell Contact -0.1226 0.0060472738989172 Scatter Plot
Target SEMA3 Source THY1 THY1 Cell-Cell Contact -0.1142 0.0105710324204792 Scatter Plot
Target SEMA3 Source MHC-II MHC-II Cell-Cell Contact -0.1061 0.0176654797663264 Scatter Plot
Target SEMA3 Source PDGF PDGF Secreted Signaling -0.1046 0.0193231351927151 Scatter Plot
Target SEMA3 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.1025 0.0218919571703064 Scatter Plot
Source SEMA3 Source SELPLG SELPLG Cell-Cell Contact -0.1001 0.0252387873974031 Scatter Plot
Target SEMA3 Target COLLAGEN COLLAGEN ECM-Receptor -0.0975 0.0293328926974014 Scatter Plot
Source SEMA3 Source SEMA4 SEMA4 Cell-Cell Contact -0.0967 0.030618045569409 Scatter Plot
Target SEMA3 Target GALECTIN GALECTIN Secreted Signaling 0.0969 0.0303438900384598 Scatter Plot
Source SEMA3 Target RANKL RANKL Secreted Signaling 0.0996 0.0260094363637706 Scatter Plot
Target SEMA3 Target SPP1 SPP1 Secreted Signaling 0.1014 0.0233763479019851 Scatter Plot
Target SEMA3 Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.1024 0.0220183884829219 Scatter Plot
Target SEMA3 Target SEMA7 SEMA7 Cell-Cell Contact 0.1047 0.0191576890864934 Scatter Plot
Source SEMA3 Target GALECTIN GALECTIN Secreted Signaling 0.1052 0.0186108436474739 Scatter Plot
Target SEMA3 Target CD45 CD45 Cell-Cell Contact 0.1058 0.0179968777076446 Scatter Plot
Source SEMA3 Target IL6 IL6 Secreted Signaling 0.1061 0.0176748627422755 Scatter Plot
Target SEMA3 Target THY1 THY1 Cell-Cell Contact 0.1067 0.016966993029503 Scatter Plot
Target SEMA3 Target PDGF PDGF Secreted Signaling 0.1085 0.015257019860863 Scatter Plot
Target SEMA3 Target TWEAK TWEAK Secreted Signaling 0.1096 0.0141631858144294 Scatter Plot
Target SEMA3 Target IL1 IL1 Secreted Signaling 0.1105 0.0134539531303243 Scatter Plot
Target SEMA3 Target SLURP SLURP Secreted Signaling 0.1123 0.0119962850453478 Scatter Plot
Source SEMA3 Target VISFATIN VISFATIN Secreted Signaling 0.1151 0.0100286429486399 Scatter Plot
Target SEMA3 Target EPHA EPHA Cell-Cell Contact 0.1160 0.0094136178229142 Scatter Plot
Target SEMA3 Target TGFb TGFb Secreted Signaling 0.1174 0.0086100102544082 Scatter Plot
Target SEMA3 Target CD86 CD86 Cell-Cell Contact 0.1178 0.008359056433286 Scatter Plot
Source SEMA3 Target MK MK Secreted Signaling 0.1195 0.0074601434584153 Scatter Plot
Source SEMA3 Source CCL CCL Secreted Signaling 0.1196 0.0074256540273329 Scatter Plot
Target SEMA3 Target THBS THBS ECM-Receptor 0.1245 0.0052915433942702 Scatter Plot
Target SEMA3 Target NCAM NCAM Cell-Cell Contact 0.1250 0.0051359642911055 Scatter Plot
Source SEMA3 Target PTN PTN Secreted Signaling 0.1267 0.0045407451151937 Scatter Plot
Target SEMA3 Target NOTCH NOTCH Cell-Cell Contact 0.1272 0.0043774602013766 Scatter Plot
Source SEMA3 Source THBS THBS ECM-Receptor 0.1274 0.0043405339284082 Scatter Plot
Target SEMA3 Target LAMININ LAMININ ECM-Receptor 0.1284 0.0040150713144553 Scatter Plot
Target SEMA3 Target CD23 CD23 Cell-Cell Contact 0.1293 0.0037730027055153 Scatter Plot
Target SEMA3 Target RANKL RANKL Secreted Signaling 0.1300 0.0036027673055202 Scatter Plot
Target SEMA3 Target CD22 CD22 Cell-Cell Contact 0.1304 0.0034929301300462 Scatter Plot
Target SEMA3 Target CD200 CD200 Cell-Cell Contact 0.1307 0.0034049450970604 Scatter Plot
Target SEMA3 Target PTN PTN Secreted Signaling 0.1310 0.0033419131235948 Scatter Plot
Source SEMA3 Source AGRN AGRN ECM-Receptor 0.1329 0.0029146079388125 Scatter Plot
Target SEMA3 Target VEGF VEGF Secreted Signaling 0.1330 0.0028802265292949 Scatter Plot
Source SEMA3 Source CD1D2 CD1D2 Cell-Cell Contact 0.1351 0.0024722566937371 Scatter Plot
Target SEMA3 Target TENASCIN TENASCIN ECM-Receptor 0.1354 0.0024141652467938 Scatter Plot
Source SEMA3 Target OSM OSM Secreted Signaling 0.1370 0.002135030953773 Scatter Plot
Target SEMA3 Target ANGPTL ANGPTL Secreted Signaling 0.1419 0.0014661664204979 Scatter Plot
Source SEMA3 Source ICAM ICAM Cell-Cell Contact 0.1427 0.0013828798157524 Scatter Plot
Target SEMA3 Target FGF FGF Secreted Signaling 0.1437 0.0012701582786871 Scatter Plot
Target SEMA3 Target ACTIVIN ACTIVIN Secreted Signaling 0.1438 0.0012624021999845 Scatter Plot
Source SEMA3 Target FN1 FN1 ECM-Receptor 0.1439 0.001255127432883 Scatter Plot
Target SEMA3 Target NPR2 NPR2 Secreted Signaling 0.1442 0.0012268634341179 Scatter Plot
Source SEMA3 Source CD39 CD39 Cell-Cell Contact 0.1493 0.0008134674672655 Scatter Plot
Source SEMA3 Target NCAM NCAM Cell-Cell Contact 0.1493 0.0008086998550563 Scatter Plot
Source SEMA3 Target BAFF BAFF Secreted Signaling 0.1495 0.0007988282725071 Scatter Plot
Source SEMA3 Target PARs PARs Secreted Signaling 0.1496 0.000794217340491 Scatter Plot
Source SEMA3 Target SEMA5 SEMA5 Cell-Cell Contact 0.1510 0.0007034615224148 Scatter Plot
Source SEMA3 Target SPP1 SPP1 Secreted Signaling 0.1528 0.0006078737122496 Scatter Plot
Source SEMA3 Target COMPLEMENT COMPLEMENT Secreted Signaling 0.1562 0.0004574889860288 Scatter Plot
Source SEMA3 Target KIT KIT Secreted Signaling 0.1566 0.0004409593976265 Scatter Plot
Source SEMA3 Source CD86 CD86 Cell-Cell Contact 0.1579 0.00039249581633 Scatter Plot
Source SEMA3 Target IL1 IL1 Secreted Signaling 0.1588 0.0003636811997533 Scatter Plot
Source SEMA3 Source THY1 THY1 Cell-Cell Contact 0.1591 0.0003543202517852 Scatter Plot
Source SEMA3 Source IL16 IL16 Secreted Signaling 0.1613 0.000292271016568 Scatter Plot
Source SEMA3 Target EPHA EPHA Cell-Cell Contact 0.1646 0.0002183985262025 Scatter Plot
Source SEMA3 Target CD22 CD22 Cell-Cell Contact 0.1655 0.0002020783552639 Scatter Plot
Source SEMA3 Source CD45 CD45 Cell-Cell Contact 0.1655 0.0002020783552639 Scatter Plot
Target SEMA3 Target IGF IGF Secreted Signaling 0.1657 0.0001979085164323 Scatter Plot
Target SEMA3 Target ESAM ESAM Cell-Cell Contact 0.1685 0.0001540084546368 Scatter Plot
Source SEMA3 Source NT NT Secreted Signaling 0.1701 0.000132645721087 Scatter Plot
Source SEMA3 Source CXCL CXCL Secreted Signaling 0.1712 0.0001198277589967 Scatter Plot
Target SEMA3 Target BAFF BAFF Secreted Signaling 0.1730 0.0001007827020958 Scatter Plot
Target SEMA3 Target APP APP Cell-Cell Contact 0.1731 0.00009981304879647232 Scatter Plot
Target SEMA3 Target VTN VTN ECM-Receptor 0.1733 0.00009779406489487216 Scatter Plot
Target SEMA3 Target VISFATIN VISFATIN Secreted Signaling 0.1767 0.00007106005885373432 Scatter Plot
Source SEMA3 Target NODAL NODAL Secreted Signaling 0.1770 0.00006884319933212743 Scatter Plot
Source SEMA3 Source MK MK Secreted Signaling 0.1778 0.0000640194763722443 Scatter Plot
Target SEMA3 Target ncWNT ncWNT Secreted Signaling 0.1800 0.000051826665526064856 Scatter Plot
Source SEMA3 Target COLLAGEN COLLAGEN ECM-Receptor 0.1802 0.00005071571236275787 Scatter Plot
Source SEMA3 Source EPHB EPHB Cell-Cell Contact 0.1804 0.00004980045605317754 Scatter Plot
Target SEMA3 Target CADM CADM Cell-Cell Contact 0.1814 0.00004501538827526434 Scatter Plot
Source SEMA3 Target EPHB EPHB Cell-Cell Contact 0.1815 0.00004459966427384086 Scatter Plot
Source SEMA3 Target VTN VTN ECM-Receptor 0.1826 0.0000400924966163061 Scatter Plot
Target SEMA3 Target CLEC CLEC Cell-Cell Contact 0.1837 0.00003600735137586545 Scatter Plot
Source SEMA3 Target SEMA4 SEMA4 Cell-Cell Contact 0.1839 0.00003517458684709155 Scatter Plot
Target SEMA3 Target NODAL NODAL Secreted Signaling 0.1844 0.00003338411430019988 Scatter Plot
Source SEMA3 Target CD45 CD45 Cell-Cell Contact 0.1897 0.000019530299220281044 Scatter Plot
Source SEMA3 Source LAMININ LAMININ ECM-Receptor 0.1912 0.00001675100089227314 Scatter Plot
Source SEMA3 Target SEMA7 SEMA7 Cell-Cell Contact 0.1930 0.000013941925611814028 Scatter Plot
Source SEMA3 Target THY1 THY1 Cell-Cell Contact 0.1974 0.000008716785818897396 Scatter Plot
Source SEMA3 Target VWF VWF ECM-Receptor 0.1976 0.000008493008255010534 Scatter Plot
Target SEMA3 Target DMP1 DMP1 ECM-Receptor 0.1998 0.000006731651796565465 Scatter Plot
Source SEMA3 Source PSAP PSAP Secreted Signaling 0.1999 0.00000663043792901612 Scatter Plot
Target SEMA3 Target VCAM VCAM Cell-Cell Contact 0.2003 0.000006404996179009069 Scatter Plot
Source SEMA3 Source CD46 CD46 Cell-Cell Contact 0.2010 0.000005882823809871264 Scatter Plot
Target SEMA3 Target JAM JAM Cell-Cell Contact 0.2011 0.000005838113602186815 Scatter Plot
Source SEMA3 Source IL2 IL2 Secreted Signaling 0.2026 0.000004978076235745618 Scatter Plot
Source SEMA3 Target CD200 CD200 Cell-Cell Contact 0.2032 0.000004631300490306479 Scatter Plot
Source SEMA3 Source FLT3 FLT3 Secreted Signaling 0.2048 0.000003876925196452229 Scatter Plot
Target SEMA3 Target OSM OSM Secreted Signaling 0.2056 0.000003557404354596829 Scatter Plot
Target SEMA3 Target CDH CDH Cell-Cell Contact 0.2057 0.0000035353169953780085 Scatter Plot
Source SEMA3 Target GDF GDF Secreted Signaling 0.2059 0.000003448802300797832 Scatter Plot
Target SEMA3 Target NRG NRG Secreted Signaling 0.2086 0.0000025501307451690678 Scatter Plot
Target SEMA3 Target PERIOSTIN PERIOSTIN Secreted Signaling 0.2093 0.000002339960346556656 Scatter Plot
Source SEMA3 Target CD23 CD23 Cell-Cell Contact 0.2098 0.000002215313513866823 Scatter Plot
Target SEMA3 Target IL6 IL6 Secreted Signaling 0.2111 0.000001914918417792193 Scatter Plot
Source SEMA3 Target SEMA6 SEMA6 Cell-Cell Contact 0.2123 0.0000016641677896293466 Scatter Plot
Source SEMA3 Target TENASCIN TENASCIN ECM-Receptor 0.2163 0.000001045055975200253 Scatter Plot
Target SEMA3 Target CCL CCL Secreted Signaling 0.2177 0.000000884984023636116 Scatter Plot
Target SEMA3 Target BSP BSP ECM-Receptor 0.2183 0.0000008227926887913911 Scatter Plot
Target SEMA3 Target MIF MIF Secreted Signaling 0.2218 0.0000005417942502889426 Scatter Plot
Source SEMA3 Source BST2 BST2 Cell-Cell Contact 0.2219 0.0000005411070697221873 Scatter Plot
Target SEMA3 Target WNT WNT Secreted Signaling 0.2250 0.0000003693402577248613 Scatter Plot
Target SEMA3 Target SELPLG SELPLG Cell-Cell Contact 0.2262 0.0000003193445685063552 Scatter Plot
Source SEMA3 Target LAMININ LAMININ ECM-Receptor 0.2271 0.00000028675292264351974 Scatter Plot
Source SEMA3 Target ANGPTL ANGPTL Secreted Signaling 0.2327 0.0000001410659904534568 Scatter Plot
Source SEMA3 Source NOTCH NOTCH Cell-Cell Contact 0.2340 0.0000001205733486351031 Scatter Plot
Source SEMA3 Source GP1BA GP1BA Cell-Cell Contact 0.2348 0.00000010899944403702645 Scatter Plot
Target SEMA3 Target CXCL CXCL Secreted Signaling 0.2383 0.00000006903078328627916 Scatter Plot
Source SEMA3 Target THBS THBS ECM-Receptor 0.2405 0.000000051606269236406375 Scatter Plot
Source SEMA3 Source CADM CADM Cell-Cell Contact 0.2436 0.000000034530620168045445 Scatter Plot
Source SEMA3 Target CADM CADM Cell-Cell Contact 0.2436 0.000000034530620168045445 Scatter Plot
Source SEMA3 Target ANGPT ANGPT Secreted Signaling 0.2442 0.000000031689373948267655 Scatter Plot
Source SEMA3 Source CSF CSF Secreted Signaling 0.2451 0.000000028152039592376027 Scatter Plot
Source SEMA3 Target CSPG4 CSPG4 Cell-Cell Contact 0.2462 0.000000024514061769913423 Scatter Plot
Source SEMA3 Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.2467 0.000000022922986820688715 Scatter Plot
Source SEMA3 Target PERIOSTIN PERIOSTIN Secreted Signaling 0.2499 0.000000014763071472968784 Scatter Plot
Source SEMA3 Target IGF IGF Secreted Signaling 0.2515 0.000000011805471654457982 Scatter Plot
Source SEMA3 Target BSP BSP ECM-Receptor 0.2538 0.000000008653978965893005 Scatter Plot
Source SEMA3 Target CD39 CD39 Cell-Cell Contact 0.2568 0.000000005678724954101436 Scatter Plot
Source SEMA3 Target NRG NRG Secreted Signaling 0.2578 0.000000004902271582252315 Scatter Plot
Source SEMA3 Target MIF MIF Secreted Signaling 0.2591 0.000000004096140373037622 Scatter Plot
Source SEMA3 Target TGFb TGFb Secreted Signaling 0.2602 0.0000000034909598659116604 Scatter Plot
Source SEMA3 Source COLLAGEN COLLAGEN ECM-Receptor 0.2634 0.0000000021999472273220676 Scatter Plot
Source SEMA3 Target DMP1 DMP1 ECM-Receptor 0.2641 0.000000002014567184281169 Scatter Plot
Source SEMA3 Target CD34 CD34 Cell-Cell Contact 0.2648 0.0000000017993945716111723 Scatter Plot
Source SEMA3 Target FGF FGF Secreted Signaling 0.2651 0.000000001727762380276323 Scatter Plot
Source SEMA3 Target CDH CDH Cell-Cell Contact 0.2656 0.000000001602732561192976 Scatter Plot
Source SEMA3 Source PDGF PDGF Secreted Signaling 0.2675 0.000000001218309938568422 Scatter Plot
Source SEMA3 Source BMP BMP Secreted Signaling 0.2695 0.0000000009009401753828883 Scatter Plot
Source SEMA3 Target BMP BMP Secreted Signaling 0.2699 0.0000000008602841638266687 Scatter Plot
Source SEMA3 Target APP APP Cell-Cell Contact 0.2717 0.0000000006568889856394306 Scatter Plot
Source SEMA3 Target JAM JAM Cell-Cell Contact 0.2759 0.00000000034403921233935996 Scatter Plot
Source SEMA3 Source MHC-II MHC-II Cell-Cell Contact 0.2768 0.00000000030165360768604717 Scatter Plot
Source SEMA3 Target ACTIVIN ACTIVIN Secreted Signaling 0.2784 0.00000000023625387734409645 Scatter Plot
Source SEMA3 Source JAM JAM Cell-Cell Contact 0.2816 0.00000000014407600560184038 Scatter Plot
Source SEMA3 Source LCK LCK Cell-Cell Contact 0.2816 0.0000000001437452175941932 Scatter Plot
Source SEMA3 Source CX3C CX3C Secreted Signaling 0.2839 0.000000000100844307802022 Scatter Plot
Source SEMA3 Source IGF IGF Secreted Signaling 0.2842 0.00000000009583058208853391 Scatter Plot
Source SEMA3 Source GAS GAS Secreted Signaling 0.2866 0.00000000006574027291491351 Scatter Plot
Source SEMA3 Source IL7 IL7 Secreted Signaling 0.2876 0.000000000056390825704033385 Scatter Plot
Source SEMA3 Source MHC-I MHC-I Cell-Cell Contact 0.2878 0.000000000054483787769827286 Scatter Plot
Target SEMA3 Target CSF CSF Secreted Signaling 0.2888 0.00000000004641302285766997 Scatter Plot
Source SEMA3 Source SEMA7 SEMA7 Cell-Cell Contact 0.2899 0.00000000003845808153947088 Scatter Plot
Source SEMA3 Target NPR2 NPR2 Secreted Signaling 0.2938 0.000000000020569853136592036 Scatter Plot
Source SEMA3 Target ncWNT ncWNT Secreted Signaling 0.2964 0.000000000013422167884287358 Scatter Plot
Source SEMA3 Target ESAM ESAM Cell-Cell Contact 0.2977 0.000000000010751136896688867 Scatter Plot
Source SEMA3 Source ESAM ESAM Cell-Cell Contact 0.2977 0.000000000010751136896688867 Scatter Plot
Target SEMA3 Target CD52 CD52 Cell-Cell Contact 0.3252 0.00000000000008845261923521649 Scatter Plot
Target SEMA3 Target IFN-II IFN-II Secreted Signaling 0.3260 0.00000000000007628808198643085 Scatter Plot
Source SEMA3 Target WNT WNT Secreted Signaling 0.3321 0.000000000000024337692237074278 Scatter Plot
Source SEMA3 Target SLURP SLURP Secreted Signaling 0.3410 0.0000000000000043978515847349774 Scatter Plot
Source SEMA3 Target AGT AGT Secreted Signaling 0.4025 0.000000000000000000006700381362258886 Scatter Plot
Target SEMA3 Target PARs PARs Secreted Signaling -0.2895 0.00000000004140583974893672 Scatter Plot
Target SEMA3 Target MK MK Secreted Signaling -0.2484 0.000000018176996208494235 Scatter Plot
Target SEMA3 Target KIT KIT Secreted Signaling -0.2339 0.00000012228667249506618 Scatter Plot
Target SEMA3 Target SEMA7 SEMA7 Cell-Cell Contact -0.1934 0.000013257027052867732 Scatter Plot
Target SEMA3 Target PTN PTN Secreted Signaling -0.1926 0.000014509885792512635 Scatter Plot
Source SEMA3 Source TGFb TGFb Secreted Signaling -0.1884 0.0000222927689450346 Scatter Plot
Source SEMA3 Source PARs PARs Secreted Signaling -0.1882 0.000022690570032279345 Scatter Plot
Source SEMA3 Source CD52 CD52 Cell-Cell Contact -0.1840 0.000034846775510153285 Scatter Plot
Source SEMA3 Target CXCL CXCL Secreted Signaling -0.1718 0.0001125646203519 Scatter Plot
Target SEMA3 Target TENASCIN TENASCIN ECM-Receptor -0.1669 0.0001774122343328 Scatter Plot
Source SEMA3 Source SEMA4 SEMA4 Cell-Cell Contact -0.1655 0.0002014400613542 Scatter Plot
Target SEMA3 Target FN1 FN1 ECM-Receptor -0.1494 0.0008046099276238 Scatter Plot
Target SEMA3 Target ANGPT ANGPT Secreted Signaling -0.1423 0.00142552567426 Scatter Plot
Target SEMA3 Target IGF IGF Secreted Signaling -0.1420 0.0014585373205674 Scatter Plot
Source SEMA3 Target CD52 CD52 Cell-Cell Contact -0.1307 0.003423786036802 Scatter Plot
Source SEMA3 Target VEGF VEGF Secreted Signaling -0.1291 0.0038316728341774 Scatter Plot
Target SEMA3 Target ICAM ICAM Cell-Cell Contact -0.1291 0.0038452406452549 Scatter Plot
Target SEMA3 Target ADIPONECTIN ADIPONECTIN Secreted Signaling -0.1289 0.0038987055144575 Scatter Plot
Source SEMA3 Source SELL SELL Cell-Cell Contact -0.1266 0.0045909524407422 Scatter Plot
Source SEMA3 Source COMPLEMENT COMPLEMENT Secreted Signaling -0.1257 0.004888880772402 Scatter Plot
Target SEMA3 Target SPP1 SPP1 Secreted Signaling -0.1246 0.0052806425593381 Scatter Plot
Source SEMA3 Source MIF MIF Secreted Signaling -0.1215 0.0065342103396447 Scatter Plot
Target SEMA3 Target IL1 IL1 Secreted Signaling -0.1162 0.0092980498868867 Scatter Plot
Source SEMA3 Target CLEC CLEC Cell-Cell Contact -0.1122 0.0120235072909065 Scatter Plot
Target SEMA3 Target ncWNT ncWNT Secreted Signaling -0.1101 0.0137334819721561 Scatter Plot
Target SEMA3 Target ANNEXIN ANNEXIN Secreted Signaling -0.1090 0.0147378857575043 Scatter Plot
Source SEMA3 Source IL1 IL1 Secreted Signaling -0.1033 0.0209090310170576 Scatter Plot
Source SEMA3 Source SELPLG SELPLG Cell-Cell Contact -0.1001 0.0252387873974031 Scatter Plot
Source SEMA3 Source NKG2D NKG2D Cell-Cell Contact -0.1001 0.0252597411212657 Scatter Plot
Source SEMA3 Target GRN GRN Secreted Signaling -0.0999 0.0254330219336197 Scatter Plot
Target SEMA3 Target GRN GRN Secreted Signaling -0.0998 0.0256552693250302 Scatter Plot
Source SEMA3 Source CCL CCL Secreted Signaling -0.0998 0.0256701206062078 Scatter Plot
Source SEMA3 Source CLEC CLEC Cell-Cell Contact -0.0983 0.0279068685054332 Scatter Plot
Source SEMA3 Target ICAM ICAM Cell-Cell Contact -0.0965 0.0309790159537762 Scatter Plot
Target SEMA3 Target FGF FGF Secreted Signaling -0.0963 0.0313810332109332 Scatter Plot

Cells that are targets of SEMA3 from HSCs*

Cells that are source of SEMA3 to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.