Pathway: CD200

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Cell-Cell Contact

Details on the CD200 pathway:

Specificity Index HSPC as target: 0.610
HSPC as source: 0.185

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the CD200 pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target CD200 Source ANNEXIN ANNEXIN Secreted Signaling 0.1037 0.02040727025627 Scatter Plot
Target CD200 Source IL6 IL6 Secreted Signaling 0.1051 0.0187764294091109 Scatter Plot
Target CD200 Source SEMA6 SEMA6 Cell-Cell Contact 0.1074 0.0162699989370944 Scatter Plot
Target CD200 Source OSM OSM Secreted Signaling 0.1086 0.0151008481392035 Scatter Plot
Target CD200 Source WNT WNT Secreted Signaling 0.1237 0.0055980460896174 Scatter Plot
Target CD200 Target LAIR1 LAIR1 Cell-Cell Contact 0.1287 0.0039379248854951 Scatter Plot
Target CD200 Target BST2 BST2 Cell-Cell Contact 0.1287 0.0039379248854951 Scatter Plot
Target CD200 Target SEMA3 SEMA3 Secreted Signaling 0.1307 0.0034049450970604 Scatter Plot
Target CD200 Source PTN PTN Secreted Signaling 0.1347 0.0025458966932025 Scatter Plot
Target CD200 Source ICOS ICOS Cell-Cell Contact 0.1352 0.0024552299958771 Scatter Plot
Target CD200 Source ncWNT ncWNT Secreted Signaling 0.1413 0.0015430093316919 Scatter Plot
Target CD200 Target NOTCH NOTCH Cell-Cell Contact 0.1414 0.0015271431722326 Scatter Plot
Target CD200 Target MK MK Secreted Signaling 0.1478 0.0009164069944326 Scatter Plot
Target CD200 Source THBS THBS ECM-Receptor 0.1608 0.0003066860998902 Scatter Plot
Target CD200 Target VEGF VEGF Secreted Signaling 0.1640 0.0002301981068093 Scatter Plot
Target CD200 Target COLLAGEN COLLAGEN ECM-Receptor 0.1726 0.0001045591064673 Scatter Plot
Target CD200 Target EPHA EPHA Cell-Cell Contact 0.1879 0.000023443532137665745 Scatter Plot
Target CD200 Source NT NT Secreted Signaling 0.1886 0.00002196250232862361 Scatter Plot
Target CD200 Target SELL SELL Cell-Cell Contact 0.1912 0.00001680741578349715 Scatter Plot
Target CD200 Source CD34 CD34 Cell-Cell Contact 0.1918 0.000015732716928147763 Scatter Plot
Target CD200 Target PTN PTN Secreted Signaling 0.1961 0.000010058421575011148 Scatter Plot
Target CD200 Target COMPLEMENT COMPLEMENT Secreted Signaling 0.1999 0.000006667783602641837 Scatter Plot
Target CD200 Source SEMA3 SEMA3 Secreted Signaling 0.2032 0.000004631300490306479 Scatter Plot
Target CD200 Target SEMA7 SEMA7 Cell-Cell Contact 0.2063 0.0000033039406647014745 Scatter Plot
Target CD200 Source CD46 CD46 Cell-Cell Contact 0.2087 0.0000025036451980584947 Scatter Plot
Target CD200 Source GDF GDF Secreted Signaling 0.2116 0.0000018036225981031985 Scatter Plot
Target CD200 Source CADM CADM Cell-Cell Contact 0.2122 0.0000016791265697738784 Scatter Plot
Target CD200 Target CADM CADM Cell-Cell Contact 0.2123 0.0000016657324974409624 Scatter Plot
Target CD200 Source ANGPTL ANGPTL Secreted Signaling 0.2144 0.000001311929048974641 Scatter Plot
Target CD200 Target CD23 CD23 Cell-Cell Contact 0.2299 0.0000002028525191124948 Scatter Plot
Target CD200 Source VCAM VCAM Cell-Cell Contact 0.2353 0.00000010227506571296789 Scatter Plot
Target CD200 Target CSPG4 CSPG4 Cell-Cell Contact 0.2354 0.00000010073958034066745 Scatter Plot
Target CD200 Source THY1 THY1 Cell-Cell Contact 0.2614 0.000000002966604951918545 Scatter Plot
Target CD200 Source IL2 IL2 Secreted Signaling 0.2635 0.000000002167652292340384 Scatter Plot
Target CD200 Target NCAM NCAM Cell-Cell Contact 0.2655 0.000000001631796361823452 Scatter Plot
Target CD200 Target VWF VWF ECM-Receptor 0.2725 0.0000000005753809178617285 Scatter Plot
Target CD200 Target SEMA6 SEMA6 Cell-Cell Contact 0.2812 0.00000000015449605743502201 Scatter Plot
Target CD200 Target GDF GDF Secreted Signaling 0.2934 0.00000000002186184783517191 Scatter Plot
Target CD200 Source CD1D2 CD1D2 Cell-Cell Contact 0.2953 0.000000000016094647369738548 Scatter Plot
Target CD200 Source RANKL RANKL Secreted Signaling 0.3006 0.000000000006709061126836638 Scatter Plot
Target CD200 Source NOTCH NOTCH Cell-Cell Contact 0.3010 0.000000000006258415166626563 Scatter Plot
Target CD200 Target THBS THBS ECM-Receptor 0.3029 0.000000000004563640077301046 Scatter Plot
Target CD200 Source CXCL CXCL Secreted Signaling 0.3055 0.0000000000028872067845992706 Scatter Plot
Target CD200 Source CD39 CD39 Cell-Cell Contact 0.3514 0.0000000000000005583889793687717 Scatter Plot
Target CD200 Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.3523 0.0000000000000004621437058968171 Scatter Plot
Target CD200 Source VEGF VEGF Secreted Signaling 0.3564 0.00000000000000020140144044669448 Scatter Plot
Target CD200 Source LIFR LIFR Secreted Signaling 0.3581 0.00000000000000014131881857880827 Scatter Plot
Target CD200 Source PROS PROS Secreted Signaling 0.3637 0.00000000000000004360360441657949 Scatter Plot
Target CD200 Source LIGHT LIGHT Secreted Signaling 0.3658 0.000000000000000028193428547610056 Scatter Plot
Target CD200 Source CCL CCL Secreted Signaling 0.3676 0.000000000000000019074113493052072 Scatter Plot
Target CD200 Source EPHB EPHB Cell-Cell Contact 0.3688 0.0000000000000000147212503861115 Scatter Plot
Target CD200 Source LCK LCK Cell-Cell Contact 0.3854 0.0000000000000000003692190582942891 Scatter Plot
Target CD200 Source IGF IGF Secreted Signaling 0.3869 0.00000000000000000026247632475898533 Scatter Plot
Target CD200 Target DMP1 DMP1 ECM-Receptor 0.3877 0.0000000000000000002187502646468888 Scatter Plot
Target CD200 Source FLT3 FLT3 Secreted Signaling 0.3878 0.0000000000000000002144672388712567 Scatter Plot
Target CD200 Target BSP BSP ECM-Receptor 0.3919 0.00000000000000000008314075165330791 Scatter Plot
Target CD200 Source CSF CSF Secreted Signaling 0.3935 0.00000000000000000005796307512043496 Scatter Plot
Target CD200 Source ICAM ICAM Cell-Cell Contact 0.3959 0.00000000000000000003279234763405005 Scatter Plot
Target CD200 Target KIT KIT Secreted Signaling 0.4103 0.000000000000000000000987058182462799 Scatter Plot
Target CD200 Source MK MK Secreted Signaling 0.4122 0.0000000000000000000006179276643673856 Scatter Plot
Target CD200 Target ACTIVIN ACTIVIN Secreted Signaling 0.4152 0.00000000000000000000029213011876991854 Scatter Plot
Target CD200 Source CDH CDH Cell-Cell Contact 0.4193 0.00000000000000000000010293106245977742 Scatter Plot
Target CD200 Target CDH CDH Cell-Cell Contact 0.4197 0.00000000000000000000009391254998290251 Scatter Plot
Target CD200 Source CX3C CX3C Secreted Signaling 0.4256 0.000000000000000000000020044072586929602 Scatter Plot
Target CD200 Target BMP BMP Secreted Signaling 0.4273 0.000000000000000000000012908859038354389 Scatter Plot
Target CD200 Source PDGF PDGF Secreted Signaling 0.4285 0.000000000000000000000009530869012462227 Scatter Plot
Target CD200 Target IGF IGF Secreted Signaling 0.4369 0.000000000000000000000000991824628341708 Scatter Plot
Target CD200 Source LAMININ LAMININ ECM-Receptor 0.4372 0.0000000000000000000000009159315387578855 Scatter Plot
Target CD200 Target CD34 CD34 Cell-Cell Contact 0.4529 0.000000000000000000000000011663534923222852 Scatter Plot
Target CD200 Target TGFb TGFb Secreted Signaling 0.4718 0.000000000000000000000000000044054762344744254 Scatter Plot
Target CD200 Source CD86 CD86 Cell-Cell Contact 0.4776 0.00000000000000000000000000000739479524492582 Scatter Plot
Target CD200 Source BST2 BST2 Cell-Cell Contact 0.4837 0.0000000000000000000000000000010848478044417536 Scatter Plot
Target CD200 Source TWEAK TWEAK Secreted Signaling 0.4942 0.00000000000000000000000000000003674541874457149 Scatter Plot
Target CD200 Source PSAP PSAP Secreted Signaling 0.4985 0.000000000000000000000000000000008992792768207723 Scatter Plot
Target CD200 Source IL7 IL7 Secreted Signaling 0.5019 0.0000000000000000000000000000000028461442559902778 Scatter Plot
Target CD200 Source SEMA7 SEMA7 Cell-Cell Contact 0.5072 0.000000000000000000000000000000000473029804139856 Scatter Plot
Target CD200 Target FGF FGF Secreted Signaling 0.5096 0.0000000000000000000000000000000002091910873822438 Scatter Plot
Target CD200 Source CD45 CD45 Cell-Cell Contact 0.5155 0.00000000000000000000000000000000002618763023528923 Scatter Plot
Target CD200 Target CD22 CD22 Cell-Cell Contact 0.5159 0.00000000000000000000000000000000002337851611830868 Scatter Plot
Target CD200 Target CD39 CD39 Cell-Cell Contact 0.5260 0.00000000000000000000000000000000000062372245600468165 Scatter Plot
Target CD200 Source IL16 IL16 Secreted Signaling 0.5330 0.00000000000000000000000000000000000004720192844223958 Scatter Plot
Target CD200 Source ESAM ESAM Cell-Cell Contact 0.5367 0.000000000000000000000000000000000000011761117136338414 Scatter Plot
Target CD200 Source BMP BMP Secreted Signaling 0.5397 0.0000000000000000000000000000000000000037579365736279465 Scatter Plot
Target CD200 Source JAM JAM Cell-Cell Contact 0.5537 0.00000000000000000000000000000000000000001621535693988799 Scatter Plot
Target CD200 Source COLLAGEN COLLAGEN ECM-Receptor 0.5569 0.000000000000000000000000000000000000000004324610831666899 Scatter Plot
Target CD200 Source ANGPT ANGPT Secreted Signaling 0.5738 0.0000000000000000000000000000000000000000000039003923187718974 Scatter Plot
Target CD200 Source GAS GAS Secreted Signaling 0.6110 0.0000000000000000000000000000000000000000000000000001589830803481062 Scatter Plot
Target CD200 Source MHC-I MHC-I Cell-Cell Contact 0.6534 0.00000000000000000000000000000000000000000000000000000000000003103332408282933 Scatter Plot
Target CD200 Source MHC-II MHC-II Cell-Cell Contact 0.6878 0.00000000000000000000000000000000000000000000000000000000000000000000002421037799295373 Scatter Plot
Target CD200 Source TGFb TGFb Secreted Signaling -0.4379 0.0000000000000000000000007704505911294234 Scatter Plot
Target CD200 Source MIF MIF Secreted Signaling -0.3380 0.000000000000007851744744091139 Scatter Plot
Target CD200 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.3279 0.000000000000053882025642720126 Scatter Plot
Target CD200 Source CD52 CD52 Cell-Cell Contact -0.2952 0.00000000001641275104142176 Scatter Plot
Target CD200 Source COMPLEMENT COMPLEMENT Secreted Signaling -0.2689 0.0000000009975809347936502 Scatter Plot
Target CD200 Source SEMA4 SEMA4 Cell-Cell Contact -0.2579 0.0000000048592936423935804 Scatter Plot
Target CD200 Target CD52 CD52 Cell-Cell Contact -0.2550 0.000000007289808452427114 Scatter Plot
Target CD200 Target CSF CSF Secreted Signaling -0.2522 0.00000001074251949630231 Scatter Plot
Target CD200 Source ANGPTL ANGPTL Secreted Signaling -0.2214 0.0000005744013173520185 Scatter Plot
Target CD200 Source IL1 IL1 Secreted Signaling -0.2044 0.00000405877029711982 Scatter Plot
Target CD200 Source SELL SELL Cell-Cell Contact -0.1762 0.00007431584407328678 Scatter Plot
Target CD200 Target CXCL CXCL Secreted Signaling -0.1600 0.0003272825869343 Scatter Plot
Target CD200 Source PARs PARs Secreted Signaling -0.1527 0.0006107290704297 Scatter Plot
Target CD200 Source NKG2D NKG2D Cell-Cell Contact -0.1526 0.000616178294186 Scatter Plot
Target CD200 Source CLEC CLEC Cell-Cell Contact -0.1459 0.0010675257283451 Scatter Plot
Target CD200 Target CCL CCL Secreted Signaling -0.1398 0.0017220825378465 Scatter Plot
Target CD200 Target CEACAM CEACAM Cell-Cell Contact -0.1375 0.0020584905092191 Scatter Plot
Target CD200 Source TNF TNF Secreted Signaling -0.1262 0.0047086804277846 Scatter Plot
Target CD200 Source NCAM NCAM Cell-Cell Contact -0.1245 0.0052901147828736 Scatter Plot
Target CD200 Target IL17 IL17 Secreted Signaling -0.1210 0.0067292835405408 Scatter Plot
Target CD200 Source SPP1 SPP1 Secreted Signaling -0.1209 0.0067862432422576 Scatter Plot
Target CD200 Source GALECTIN GALECTIN Secreted Signaling -0.1098 0.014009978191704 Scatter Plot
Target CD200 Target GRN GRN Secreted Signaling -0.1028 0.0214707080966146 Scatter Plot
Target CD200 Source CCL CCL Secreted Signaling -0.1028 0.0215520527209857 Scatter Plot
Target CD200 Source VISFATIN VISFATIN Secreted Signaling -0.1018 0.0227761659504748 Scatter Plot
Target CD200 Target TWEAK TWEAK Secreted Signaling 0.1041 0.0198876884467524 Scatter Plot
Target CD200 Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1247 0.0052288485841441 Scatter Plot
Target CD200 Target OSM OSM Secreted Signaling 0.1477 0.0009269547517665 Scatter Plot
Target CD200 Target IL1 IL1 Secreted Signaling 0.1490 0.0008345126628869 Scatter Plot
Target CD200 Target FN1 FN1 ECM-Receptor 0.1612 0.0002963280041144 Scatter Plot
Target CD200 Target SPP1 SPP1 Secreted Signaling 0.1948 0.000011537777825066962 Scatter Plot
Target CD200 Target THY1 THY1 Cell-Cell Contact 0.2025 0.000005010638828437789 Scatter Plot
Target CD200 Target CADM CADM Cell-Cell Contact 0.2122 0.000001685052732332151 Scatter Plot
Target CD200 Target RANKL RANKL Secreted Signaling 0.2236 0.00000043724908201056073 Scatter Plot
Target CD200 Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2287 0.000000233988328528611 Scatter Plot
Target CD200 Target CD23 CD23 Cell-Cell Contact 0.2299 0.00000020217879319388226 Scatter Plot
Target CD200 Target CSPG4 CSPG4 Cell-Cell Contact 0.2352 0.00000010332058138107481 Scatter Plot
Target CD200 Target COLLAGEN COLLAGEN ECM-Receptor 0.2365 0.0000000878573384177846 Scatter Plot
Target CD200 Target ANGPTL ANGPTL Secreted Signaling 0.2742 0.00000000044994843450852086 Scatter Plot
Target CD200 Target PARs PARs Secreted Signaling 0.2769 0.00000000029852653785719565 Scatter Plot
Target CD200 Target VTN VTN ECM-Receptor 0.2887 0.000000000047188070933065287 Scatter Plot
Target CD200 Target NODAL NODAL Secreted Signaling 0.3004 0.000000000006880255299207972 Scatter Plot
Target CD200 Target IL6 IL6 Secreted Signaling 0.3023 0.000000000005029093809604904 Scatter Plot
Target CD200 Target SEMA5 SEMA5 Cell-Cell Contact 0.3054 0.000000000002963852886659008 Scatter Plot
Target CD200 Target GALECTIN GALECTIN Secreted Signaling 0.3085 0.0000000000017334413134537605 Scatter Plot
Target CD200 Target LAMININ LAMININ ECM-Receptor 0.3190 0.00000000000027082359551201376 Scatter Plot
Target CD200 Target VISFATIN VISFATIN Secreted Signaling 0.3442 0.0000000000000023465657993073657 Scatter Plot
Target CD200 Target EPHB EPHB Cell-Cell Contact 0.3774 0.0000000000000000022451666357659712 Scatter Plot
Target CD200 Target NRG NRG Secreted Signaling 0.3787 0.0000000000000000016830448357412388 Scatter Plot
Target CD200 Target PERIOSTIN PERIOSTIN Secreted Signaling 0.3838 0.0000000000000000005313935362179086 Scatter Plot
Target CD200 Target TENASCIN TENASCIN ECM-Receptor 0.4028 0.000000000000000000006272207400742113 Scatter Plot
Target CD200 Target ANGPT ANGPT Secreted Signaling 0.4127 0.0000000000000000000005466168967534313 Scatter Plot
Target CD200 Target CDH CDH Cell-Cell Contact 0.4191 0.00000000000000000000010911159725103737 Scatter Plot
Target CD200 Target NPR2 NPR2 Secreted Signaling 0.4290 0.000000000000000000000008237695870770857 Scatter Plot
Target CD200 Target SEMA4 SEMA4 Cell-Cell Contact 0.4308 0.0000000000000000000000051597617846010045 Scatter Plot
Target CD200 Target CD34 CD34 Cell-Cell Contact 0.4528 0.000000000000000000000000011840290699439787 Scatter Plot
Target CD200 Target BAFF BAFF Secreted Signaling 0.5042 0.000000000000000000000000000000001336391089227572 Scatter Plot
Target CD200 Target JAM JAM Cell-Cell Contact 0.5103 0.00000000000000000000000000000000016603958663223694 Scatter Plot
Target CD200 Target CD22 CD22 Cell-Cell Contact 0.5155 0.00000000000000000000000000000000002656158399776284 Scatter Plot
Target CD200 Target CD39 CD39 Cell-Cell Contact 0.5258 0.0000000000000000000000000000000000006635649469864087 Scatter Plot
Target CD200 Target ncWNT ncWNT Secreted Signaling 0.5283 0.00000000000000000000000000000000000026973894563840265 Scatter Plot
Target CD200 Target WNT WNT Secreted Signaling 0.5284 0.00000000000000000000000000000000000026263080785377565 Scatter Plot
Target CD200 Target ESAM ESAM Cell-Cell Contact 0.5367 0.000000000000000000000000000000000000011761117136338414 Scatter Plot
Target CD200 Target SLURP SLURP Secreted Signaling 0.5722 0.000000000000000000000000000000000000000000007705683189020203 Scatter Plot
Target CD200 Target APP APP Cell-Cell Contact 0.5734 0.000000000000000000000000000000000000000000004543508504479122 Scatter Plot
Target CD200 Target MIF MIF Secreted Signaling 0.6443 0.000000000000000000000000000000000000000000000000000000000005143776727539931 Scatter Plot
Target CD200 Target ICAM ICAM Cell-Cell Contact -0.2684 0.0000000010626006080381967 Scatter Plot
Target CD200 Target CD52 CD52 Cell-Cell Contact -0.2554 0.0000000069502000016524226 Scatter Plot
Target CD200 Target CSF CSF Secreted Signaling -0.2523 0.000000010572051904331181 Scatter Plot
Target CD200 Target CXCL CXCL Secreted Signaling -0.1540 0.0005473780060311 Scatter Plot
Target CD200 Target VCAM VCAM Cell-Cell Contact -0.1378 0.0020124709013593 Scatter Plot
Target CD200 Target CEACAM CEACAM Cell-Cell Contact -0.1374 0.0020673194064628 Scatter Plot
Target CD200 Target CCL CCL Secreted Signaling -0.1368 0.0021633777804704 Scatter Plot

Cells that are targets of CD200 from HSCs*

    No cell populations

Cells that are source of CD200 to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.